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Deciphering functional roles of synaptic plasticity and intrinsic neural firing in developing mouse visual cortex layer IV microcircuit

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Abstract

Between the onset of the critical period of mouse primary visual cortex and eye opening at postnatal day 14 is a complex process and that is vital for the cognitive function of vision. The onset of the critical period of mouse primary visual cortex involves changes of the intrinsic firing property of each neuron and short term plasticity of synapses. In order to investigate the functional role of each factor in regulating the circuit firing activity during the critical period plasticity, we adopted the Markram’s model for short term plasticity and Wilson’s model for intrinsic neuron firing activity, and construct a microcircuit for mouse visual cortex layer IV based on the connection probabilities from experimental results. Our results indicate that, during CP development, the most critical factors that regulate the firing pattern of microcircuit is the short term plasticity of the synapse from PC to PV and SST interneurons, which upregulates the PV interneuron firing and produces new balance between excitation and inhibition; the intrinsic firing activity of PC and PV during development downregulates the firing frequency of the circuits. In addition, we have investigated the function of feedforward excitatory thalamic-cortical projection to PC and PV interneuron during CP, and found that neural firing activity largely depends on the TC input and the results are similar to the local circuit with minor differences. We conclude that the short term plasticity development during critical period plays a crucial role in regulating the circuit behavior.

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Acknowledgements

We thank Dr. Yao (Li, Yao) for helpful discussions. This research is supported by National Key R&D Program of China (No. 2019 YFA0709503), Beijing high-level discipline construction project–cognitive neuroscience, and China National Science Foundation (No. 31601145).

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  1. School of Systems Science, Beijing Normal University, Beijing, China

    Sanwu Liu & Yinyun Li

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Highlights

Critical Period (CP) development is a specific period during early development after eye opening for mouse at postnatal day P14-P20 until the critical period onset (P20-21). The plasticity in mouse primary visual cortex layer IV during CP development involves changes of the intrinsic neuronal firing property and synaptic short term plasticity. We have investigated the functional roles of each factor in regulating the firing pattern of the microcircuits of visual cortex IV during the critical period. For local circuits, the short term plasticity changes of PC output synapses during CP increases PC and PV firing activity intensively, while the intrinsic neuronal firing properties of PC and PV interneuron down regulates the circuit’s firing activity. The local circuit switches from PC and SST firing patterns before CP to PC and PV firing patterns after CP onset. For global circuits with thalamus cell injection, neural firing activity is basically similar to the local circuit with minor differences, indicating that the short term plasticity development during critical period plays a crucial role in regulating the circuit behavior.

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Liu, S., Li, Y. Deciphering functional roles of synaptic plasticity and intrinsic neural firing in developing mouse visual cortex layer IV microcircuit. J Comput Neurosci 51, 23–42 (2023). https://doi.org/10.1007/s10827-022-00823-x

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