Abstract
Development of digital microfluidic biochips (DMFB) has faced a major setback from the threats of faulty and erroneous fluidic operations. Defective electrodes are the main reason for this misleading assay performance. It also affects the assay completion time and overall turnaround time. In this present article, a fast fault diagnosis mechanism is discussed to identify the defective locations of electrode array. The proposed fault detection method is governed by a distributed dispensing and scheduling of test droplets on a 2-D biochip. Water droplets are strategically routed across the DMFB board and quantified at every location using cost effective photodiode sensors. Multiple test droplets are routed on the chip in a time synchronized manner to avoid any routing conflict or failure in diagnosis. This concurrent test droplet circulation incurs optimum layover period and parallel and multiple test droplet movement enhances the fault detection performance. Completeness of the fault analysis is ensured with a sequential post processing as well. Test results of this approach have recorded some substantial improvement in terms of fault detection time and accuracy.
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Chakrabarty K (2010) Design automation and test solutions for digital microfluidic biochips. IEEE TCAS I 57(1):4–17
Chen Y, Khwa WSV, Yu MHV (2010) Fault detection and fault tolerant design for microfluidic based biochips. Proc of EIASC. 1–8
Cho SK, Fan SK, Moon H, Kim CJ (2002) Towards digital microuidic circuits: creating, transporting, cutting and merging liquid droplets by electrowetting-based actuation. Proc MEMS. 32–35
Datta S, Joshi B, Ravindran A, Mukherjee A (2009) Efficient parallel testing and diagnosis of digital microfluidic biochips. ACM J Emerg Technol Comput Syst 5(2):10.1–10.17, Article 10
Hu K, Hsu BN, Madison A, Chakrabarty K; Fair RB (2013) Fault detection, real time error recovery and experimental demonstration for digital microfluidic biochips. Proc Des Autom Test Eur. 559–564
Itai A, Papadimitriou CH, Szwarcfiter JL (1982) Hamiltonian paths in grid graphs. SIAM J Comput 11:676–686
Luo Y, Chakrabarty K, Ho TY (2013) Error recovery in cyberphysical digital microfluidic biochips. IEEE Trans Comput-Aided Des Integr Circuits Syst 32(1):59–72
Majumder M (2012) A novel single-fault detection technique of digital microfluidic biochip. Int J Comput Sci Its Applications [ISSN 2250–3765], VI – I-1(16);92–95
Mitra D, Ghoshal S, Rahaman H, Chakrabarty K, Bhattacharya BB (2011) Test planning in digital microfluidic biochips using efficient eulerization techniques. J Electron Test 27(5):657–671
Mitra D, Ghoshal S, Rahaman H, Chakrabarty K, Bhattacharya BB (2012) Online error detection in digital microfluidic biochips. Proc IEEE 21st Asian Test Symposium. 332–337
Pollock M, Shenderov AD, Fair RB (2002) Electrowetting-based actuation of droplets for integrated microfluidics. Lab Chip 2(2):96–101
Roy P, Rahaman H, Gupta P, Dasgupta P (2013) A new customized testing technique using a novel design of droplet motion detector for digital microfluidic biochip systems. Proc. ICACCI. 897–902
Schulte TH, Bardell RL, Weigl BH (2002) Microfluidic technologies in clinical diagnostics. Clin Chim Acta 321:1–10
Su F, Chakrabarty K (2006) Defect tolerance based on graceful degradation and dynamic reconfiguration for digital microfluidics based biochips. IEEE Trans Comput-Aided Des Integr Circuits Syst 25(12):2944–2953
Su F, Chakrabarty K, Fair RB (2006) Microfluidics-based biochips: technology issues, implementation platforms, and design automation challenges. IEEE Trans Comput-Aided Des Integr Circuits Syst 25(2):265–277
Su F, Hwang W, Mukherjee A, Chakrabarty K (2005) Defect oriented testing and diagnosis of digital microfluidics based biochips. Proc Int Test Conf 21(2):1–10
Su F, Hwang W, Mukherjee A, Chakrabarty K (2007) Testing and diagnostics of realistic defects in digital microfluidic biochips. J Electron Testing: Theory and Applications 23:219–233
Su F, Ozev S, Chakrabarty K (2003) Testing of droplet-based microelectrofluidic systems. Proce IEEE Int Test Cong 1:1192–1200
Wang WC, Yee S, Reinhall P (1995) Optical viscosity sensor using forward light scattering. Sensors Actuators B 25:753–755
Xu T, Chakrabarty K (2007) Parallel scan-like test and multiple defect diagnosis for digital microfluidic biochips. IEEE Trans on Biomedical Circuit and Systems 1(2):148–158
Xu T, Chakrabarty K (2008) Integrated droplet routing and defect tolerance in the synthesis of digital microfluidic biochips. ACM J Emerg Technol Comput Syst 4(3):11.1–11.24, Article – II
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Mukherjee, S., Samanta, T. Distributed Scan Like Fault Detection and Test Optimization for Digital Microfluidic Biochips. J Electron Test 31, 311–319 (2015). https://doi.org/10.1007/s10836-015-5525-5
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DOI: https://doi.org/10.1007/s10836-015-5525-5