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On-Line Test of Pin-Constrained Digital Microfluidic Biochips with Connect-5 Structure

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Abstract

Digital microfluidic biochips (DMFBs) are widely used in the field of biochemistry. Effective off-line and on-line test for the biochips are required to ensure the system reliability. For direct addressing digital microfluidic biochips (DDMFBs), each control pin corresponds to only one electrode, and that can facilitate the testing of such biochips. However, in pin-constrained digital microfluidic biochips (PDMFBs), multiple electrodes may share one control pin, and thus the testing will be more difficult. In this paper, the pin constraint formula for PDMFBs with connect-5 structure is derived. A novel pin assignment scheme is also proposed, which can conduct on-line test that rarely considered by the previous methods. Furthermore, a hybrid method combining the priority strategy and genetic algorithm is introduced for the on-line test of pin-constrained digital microfluidic biochip with connect-5 structure. The simulation results show that the shortest test path acquired by the proposed method is equal to the optimal value of Euler path, which indicates that the method can effectively implement the on-line test of PDMFBs with connect-5 structure.

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Acknowledgments

The authors would like to thank the reviewers for their critical and constructive review of this manuscript. And this work is supported by the National Natural Science Foundation of China (No. 61671164, No. 61861012), the Foundation of Guangxi Key Laboratory of Automatic Detecting Technology and Instruments (No. YQ17104, No. YQ18109) and Guangxi Natural Science Foundation of China (No. 2017GXNSFAA198021, No. 2018GXNSFAA294011).

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Authors and Affiliations

  1. School of Electronic Engineering and Automation, Guilin University of Electronic Technology, Guilin, 541004, China

    Xijun Huang, Chuanpei Xu & Long Zhang

  2. Guangxi Key Laboratory of Automatic Detecting Technology and Instruments, Guilin, 541004, China

    Xijun Huang, Chuanpei Xu & Long Zhang

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  1. Xijun Huang
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  2. Chuanpei Xu
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Correspondence to Chuanpei Xu.

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Responsible Editor: K. Chakrabarty

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Huang, X., Xu, C. & Zhang, L. On-Line Test of Pin-Constrained Digital Microfluidic Biochips with Connect-5 Structure. J Electron Test 37, 97–107 (2021). https://doi.org/10.1007/s10836-020-05923-z

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  • DOI: https://doi.org/10.1007/s10836-020-05923-z

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