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Enhancing the Utility of ProstaScint SPECT Scans for Patient Management

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Abstract

This project investigated reducing the artifact content of In-111 ProstaScint SPECT scans for use in treatment planning and management. Forty-one patients who had undergone CT or MRI scans and simultaneous Tc-99m RBC/In-111 ProstaScint SPECT scans were included. SPECT volume sets, reconstructed using Ordered Set-Expectation Maximum (OS-EM) were compared against those reconstructed with standard Filtered Back projection (FBP). Bladder activity in Tc-99m scans was suppressed within an ellipsoidal volume. Tc-99m voxel values were subtracted from the corresponding In-111 after scaling based on peak activity within the descending aorta. The SPECT volume data sets were merged with the CT or MRI scans before and after processing. Volume merging, based both on visual assessment and statistical evaluation, was not affected. Thus iterative reconstruction together with bladder suppression and blood pool subtraction may improve the interpretation and utility of ProstaScint SPECT scans for patient management.

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Authors and Affiliations

  1. Department of Radiology, NYU School of Medicine, New York

    Marilyn E. Noz, Grace Chung, Benjamin Y. Lee, Jay V. Doshi, Elissa L. Kramer & Antoinette D. Murphy-Walcott

  2. School of Information and Communication Technology, Kista, Sweden

    Gerald Q. Maguire Jr.

  3. Department of Radiation Oncology, NYU School of Medicine, New York

    J. Keith DeWyngaert

  4. RAHD Oncology Products, St. Louis, Missouri

    Michael P. Zeleznik

  5. UMDNJ – Robert Wood Johnson Medical School, Piscataway, New Jersey

    Noeun G. Kwak

Authors
  1. Marilyn E. Noz
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  2. Grace Chung
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Correspondence to Marilyn E. Noz.

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Noz, M.E., Chung, G., Lee, B.Y. et al. Enhancing the Utility of ProstaScint SPECT Scans for Patient Management. J Med Syst 30, 123–132 (2006). https://doi.org/10.1007/s10916-005-7987-y

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  • DOI: https://doi.org/10.1007/s10916-005-7987-y

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