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Computer-Based Identification of Breast Cancer Using Digitized Mammograms

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Abstract

High-quality mammography is the most effective technology presently available for breast cancer screening. Efforts to improve mammography focus on refining the technology and improving how it is administered and X-ray films are interpreted. Computer-based intelligent system for identification of the breast cancer can be very useful in diagnosis and its management. This paper presents a comparative approach for classification of three kinds of mammogram namely normal, benign and cancer. The features are extracted from the raw images using the image processing techniques and fed to the two classifiers namely: the feedforward architecture neural network classifier, and Gaussian mixture model (GMM) for comparison.. Our protocol uses, 360 subjects consisting of normal, benign and cancer breast conditions. We demonstrate a sensitivity and specificity of more than 90% for these classifiers.

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References

  1. American Cancer Society, Cancer Facts and Figures, 1999.

  2. Bishop, C. M., Neural networks for Pattern Recognition. Oxford University Press, Inc, New York, NY, 1995.

    Google Scholar 

  3. Byng, J. W., Boyd, N. F., Fishell, E., Jong, R. A., and Yaffe, M. J., Automated analysis of mammographic densities. Phys. Med. Biol. 41:909–923, 1996.

    Article  Google Scholar 

  4. Byng, J. W., Yaffe, M. J., Jong, R. A., Shumak, R. S., Lockwood, G. A., David, M. M., et al., Analysis of mammographic density and breast cancer risk from digitized mammograms. Radiographics. 18:1587–1598, 1998.

    Google Scholar 

  5. Cahoon, T. C., Sutton, M. A., and Bezdek, J. C., Breast cancer detection using image processing techniques. The Ninth IEEE International Conference on Fuzzy Systems. 2:973–976, 2000.

    Article  Google Scholar 

  6. Christoyianni, I., Dermatas, E., and Kokkinakis, G., Fast detection of masses in computer-aided mammography. Signal Processing Magazine IEEE. 17:154–64, 2000.

    Article  Google Scholar 

  7. Gonzalez, R.C., and Wintz, P., Digital Image Processing. Addison–Wesley Publishing Co., Reading, MA, 1987.

    Google Scholar 

  8. Gram, I. T., Bremnes, Y., Usin, G., Maskarinec, G., Bjurstam, N., and Lund, E., Percentage density, Wolfe’s and Tabar’s mammographic patterns: agreement and association with risk factors for breast cancer. Breast Cancer Res. 7:854–861, 2005.

    Article  Google Scholar 

  9. Haralick, R. M., Shanmugam, K., and Dinstein, I., Textural features for image Classification. IEEE Transactions on Systems, Man and Cybernetics. 3(6):610–621, 1973.

    Article  Google Scholar 

  10. http://marathon.csee.usf.edu/Mammography/Database.html [last accessed on 20th July 2007].

  11. http://www.medcalc.be/ [last accessed on 20th July 2007].

  12. Karlikowske, K., Grady, G., Rubin, S. M., Sandrock, C., and Ernster, V. L., Efficacy of screening mammography: a meta analysis. JAMA. 273:149–154, 1995.

    Article  Google Scholar 

  13. Nelwamondo, F. V., and Marwala, T., Faults Detection Using Gaussian Mixture Models Mel-Frequency Cepstral Coefficients and Kurtosis. Systems, Man and Cybernetics, 2006. SMC apos;06. IEEE International Conference. 1:290–295, 2006.

    Article  Google Scholar 

  14. Nystrom, L., Andersson, I., Bjurstam, N., Frisell, J., Nordenskjold, B., and Rutqvist, L. E., Long-term effects of mammography screening: updated overview of the Swedish randomised trials. Lancet. 359:909–919, 2002.

    Article  Google Scholar 

  15. Oza, A. M., and Boyd, N. F., Mammography parenchymal patterns: a marker of breast cancer risk. Epidemiol. Rev. 15:196–208, 1993.

    Google Scholar 

  16. Parker, J. R., Algorithms for Image Processing and Computer Vision. John Wiley & Sons, Inc., New York, 1997.

    Google Scholar 

  17. Parkin, D. M., Muir, C. S., Whelan, S. L., Gao, Y. T., Ferlay, J., Powel, J. (1992) Cancer incidence in Five continence series”, Vol. VI. IARC, Scientific Publication, ISBN 9283221206, No 120, IARC, Lyon.

  18. Reynolds, D. A., Speaker identification and verification using Gaussian mixture speaker models. Speech Comm. 17:91–108, 1995.

    Article  Google Scholar 

  19. Reynolds, D. A., Quatieri, T., and Dunn, R., Speaker verification using adapted Gaussian mixture models. Digital Signal Process. 10:19–41, 2000.

    Article  Google Scholar 

  20. Saha, P. K., and Udupa, J. K., Optimum image thresholding via class uncertainty and region homogeneity. IEEE Trans. Pattern Anal. Mach. Intell. 23:689–706, 2001.

    Article  Google Scholar 

  21. Seo, C., Lee, K. Y., and Lee, J., GMM based on local PCA for speaker identification. Electronics Letters. 37:1486–1488, 2001.

    Article  Google Scholar 

  22. Spicer, D. V., Ursin, G., Parisky, Y. R., Pearce, J. G., Shoupe, D., Pike, A., and Pike, M. C., Changes in mammographic densities induced by a hormonal contraceptive designed to reduce breast cancer risk. J. Natl. Cancer Inst. 86:431–436, 1994.

    Article  Google Scholar 

  23. Tabar, L., Dean, P. B., Teaching Atlas of Mammography. 2nd edn (Stuttgart: George Thieme), 5–16, 1985.

  24. Vibha, L., Harshavardhan, G. M., Pranaw, K., Shenoy, D. P., Venugopal, K. R., Patnaik, L. M. Lesion detection using segmentation and classification of mammograms. Proceedings of the 25th conference on Proceedings of the 25th IASTED International Multi-Conference: artificial intelligence and applications, Austria, 311–316, 2007.

  25. Wang, T. C., and Nicolaos, B. K., Detection of microcalcifications in digital mammograms using wavelets. IEEE transactions on medical imaging. 17(4):498–509, 1998.

    Article  Google Scholar 

  26. World Health Organization, International Agency for Research on Cancer, Biennial Report 2004–2005.

  27. Yegnanarayana, B., Artificial Neural Networks. Prentice-Hall of India, New Delhi, 1999.

    Google Scholar 

  28. Zaïane, O. R., Antonie, M. L., Coman, A., Mammography classification by an association rule-based classifier. International Workshop on Multimedia Data Mining. 2002.

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Acknowledgements

The authors like to thank The Digital Database for Screening Mammography (DDSM) of USA, for providing the source data in this mammographic image analysis.

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Correspondence to E. Y. K. Ng.

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Acharya U, R., Ng, E.Y.K., Chang, Y.H. et al. Computer-Based Identification of Breast Cancer Using Digitized Mammograms. J Med Syst 32, 499–507 (2008). https://doi.org/10.1007/s10916-008-9156-6

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  • DOI: https://doi.org/10.1007/s10916-008-9156-6

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