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A Multi-Voting Enhancement for Newborn Screening Healthcare Information System

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Abstract

The clinical symptoms of metabolic disorders during neonatal period are often not apparent. If not treated early, irreversible damages such as mental retardation may occur, even death. Therefore, practicing newborn screening is essential, imperative to prevent neonatal from these damages. In the paper, we establish a newborn screening model that utilizes Support Vector Machines (SVM) techniques and enhancements to evaluate, interpret the Methylmalonic Acidemia (MMA) metabolic disorders. The model encompasses the Feature Selections, Grid Search, Cross Validations as well as multi model Voting Mechanism. In the model, the predicting accuracy, sensitivity and specificity of MMA can be improved dramatically. The model will be able to apply to other metabolic diseases as well.

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Author information

Authors and Affiliations

  1. Information Systems Office, National Taiwan University Hospital, Taipei, Taiwan

    Sung-Huai Hsieh, Yung-Ching Weng, Sheau-Ling Hsieh & Feipei Lai

  2. Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan

    Sung-Huai Hsieh, Po-Hao Chen, Yung-Ching Weng & Feipei Lai

  3. Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

    Chi-Huang Chen & Feipei Lai

  4. Network and Computer Centre, National Chiao Tung University, Hsin Chu, Taiwan

    Sheau-Ling Hsieh

  5. Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City, Taiwan

    Feipei Lai

  6. Department of Software Engineering, National Kaohsiung Normal University, Taipei, Taiwan

    Po-Hsun Cheng

  7. Department of Computer Science and Engineering, Tatung University, Taipei, Taiwan

    Kuo-Hsuan Huang

Authors
  1. Sung-Huai Hsieh
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  2. Po-Hsun Cheng
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  3. Chi-Huang Chen
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  4. Kuo-Hsuan Huang
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  5. Po-Hao Chen
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  6. Yung-Ching Weng
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  7. Sheau-Ling Hsieh
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  8. Feipei Lai
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Corresponding author

Correspondence to Po-Hsun Cheng.

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Hsieh, SH., Cheng, PH., Chen, CH. et al. A Multi-Voting Enhancement for Newborn Screening Healthcare Information System. J Med Syst 34, 727–733 (2010). https://doi.org/10.1007/s10916-009-9287-4

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  • DOI: https://doi.org/10.1007/s10916-009-9287-4

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