Abstract
The increasing number of diabetic retinopathy (DR) cases world wide demands the development of an automated decision support system for quick and cost-effective screening of DR. We present an automatic screening system for detecting the early stage of DR, which is known as non-proliferative diabetic retinopathy (NPDR). The proposed system involves processing of fundus images for extraction of abnormal signs, such as hard exudates, cotton wool spots, and large plaque of hard exudates. A rule based classifier is used for classifying the DR into two classes, namely, normal and abnormal. The abnormal NPDR is further classified into three levels, namely, mild, moderate, and severe. To evaluate the performance of the proposed decision support framework, the algorithms have been tested on the images of STARE database. The results obtained from this study show that the proposed system can detect the bright lesions with an average accuracy of about 97%. The study further shows promising results in classifying the bright lesions correctly according to NPDR severity levels.







Similar content being viewed by others
References
Verma, L., Prakash, G., and Tewari, H. K., Diabetic retinopathy: time for action—no complacency please!. Bull. World Health Org. 805:419, 2002.
Yen, G. G., and Leong, W.-F., A sorting system for hierarchical grading of diabetic fundus images: a preliminary study. IEEE Trans. Inf. Technol. Biomed. 12 (1)118–130, 2008.
Wareham, N., Cost-effectiveness of alternative methods for diabetic retinopathy screening (letter). Diabetic Care. 16:844, 1993.
Hsu, W., Pallawala, P. M., Lee, M. L., and Eong, K. G., The role of domain knowledge in the detection of retinal hard exudates, in Proc. IEEE Comput. Vis. Pattern Recog. Conf., Hawaii Island, HI, pp. 246–251, 2001.
Vallabha, D., Dorairaj, R., Namuduri, K., and Thompson, H., Automated detection and classification of vascular abnormalities in diabetic retinopathy. Conf. Rec. Thirty-Eighth Asilomar Conf. Signals, Syst., Comput. 2:1625–1629, 2004.
Avci, R., and Kaderli, B., Intravitreal triamcinolone injection for chronic diabetic macular oedema with severe hard exudates. Graefe’s Arch. Clin. Exp/Ophthalmol. 244:28–35, 2006.
Walter, T., Klein, J.-C., Massin, P., and Erginay, A., A contribution of image processing to the diagnosis of diabetic retinopathy—detection of exudates in color fundus images of the human retina. IEEE Trans. Med. Imag. 21 (10)1236–1243, 2002.
Ward, N. P., Tomlinson, S., and Taylor, C. J., Image analysis of fundus photographs—the detection and measurement of exudates associated with diabetic retinopathy. Opthalmol. 96:80–86, 1989.
Pinz, A., Prantl, M., and Datlinger, P., Mapping the human retina. IEEE Trans. Med. Imag. 1:210–215, 1998.
Goh, K. G., Hsu, W., Lee, M. L., and Wang, H., ADRIS: an automatic diabetic retinal image screening system. In: Cios, K. J. (Ed.), Medical data mining and knowledge discovery, studies in fuzziness and soft computing. Vol. 60. Springer, Berlin, pp. 181–210, 2001.
Kahai, P., Namuduri, K. R., and Thompson, H., Decision support for automated screening of diabetic retinopathy, in Proc. Asilomar Conf. Signals Syst. Comput., Pacific Grove, CA, pp. 1630–1634, 2004.
Sinthanayothin, C., Kongbunkiat, V., Phoojaruenchanachai, S., and Singalavanija, A., Automatic screening system for diabetic retinopathy, in Proc. Int. Symp. Imag. Signal Process. Anal., Aizu, Japan, pp. 915–920, 2003.
Usher, D., Dumskyj, M., Himaga, M., Williamson, T. H., Nussey, S., and Boyce, J., Automated detection of diabetic retinopathy in digital retinal images: a tool for diabetic retinopathy screening. Diabet. Med. 21:84–90, 2003.
Reza, A. W., Eswaran, C., and Hati, S., Automatic tracing of optic disc and exudates from color fundus images using fixed and variable thresholds. J. Med. Syst. 33 (1)73–80, 2009.
Niemeijer, M., Abramoff, M. D., and van Ginneken, B., Segmentation of the optic disc, macula and vascular arch in fundus photographs. IEEE Trans. Med. Imag. 26 (1)116–127, 2007.
Li, H., and Chutatape, O., Automatic detection and boundary estimation of the optic disk in retinal images using a model-based approach. J. Electron. Imag. 12 (1)97–105, 2003.
Gonzalez, R. C., Woods, R. E., and Eddins, S. L., Digital image processing using MATLAB. Prentice Hall, Upper Saddle River, 2004.
Mendonca, A. M., and Campilho, A., Segmentation of retinal blood vessels by combining the detection of centerlines and morphological reconstruction. IEEE Trans. Med. Imag. 25 (9)1200–1213, 2006.
Acknowledgment
This research work is supported by E-Science Project (No: 01-02-01-SF0025) sponsored by Ministry of Science, Technology and Innovation (MOSTI), Malaysia.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Reza, A.W., Eswaran, C. A Decision Support System for Automatic Screening of Non-proliferative Diabetic Retinopathy. J Med Syst 35, 17–24 (2011). https://doi.org/10.1007/s10916-009-9337-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10916-009-9337-y