Abstract
Combining ASIC and multiple microsensors low-power wireless electronic capsule was developed for the long-term monitoring of the entire human gastro-intestinal (GI) tract. To meet the system requirements, several low-power designs were used in the wireless electronic capsule. The capsule measured 11 × 22 mm including batteries (45mAh). The capsule system’s lifetime was 233 h, and it could meet the requirements of almost all clinical applications. A wireless electronic capsule, portable data recorder, and workstation comprised the human GI physiological parameters monitoring system. In this paper, this system was used in a clinical trial to compare colon peristaltic pressure between patients with constipation and healthy people.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.References
Zworykin, V., and Farrar, J., Radio pill. Nature 179(4566):898, 1957.
Mackay, R. S., and Jacobson, B., Endoradiosonde. Nature 179:2, 1957.
Wolff, H., The radio pill. New Sci 12:419–421, 1961.
Arshak, A., Arshak, K., Lyons, G., Waldron, D., Morris, D., Korostynska, O., and Jafer, E., Review of the potential of a wireless MEMS microsystem for biomedical applications. Sensor Rev 25(4):277–286, 2005.
Lee, S.-Y., Su, M., Liang, M.-C., Chen, Y.-Y., Hsieh, C.-H., Yang, C.-M., Lai, H.-Y., Lin, J.-W., and Fang, Q., A programmable implantable microstimulator SoC with wireless telemetry: Application in closed-loop endocardial stimulation for cardiac pacemaker. IEEE Trans Biomed Circuits Syst 5(6):511–522, 2011.
Hammond, P. A., Ali, D., and Cumming, D. R., A system-on-chip digital pH meter for use in a wireless diagnostic capsule. IEEE Trans Biomed Eng 52(4):687–694, 2005.
Johannessen, E. A., Wang, L., Cui, L., Tang, T. B., Ahmadian, M., Astaras, A., Reid, S. W., Yam, P. S., Murray, A. F., and Flynn, B. W., Implementation of multichannel sensors for remote biomedical measurements in a microsystems format. IEEE Trans Biomed Eng 51(3):525–535, 2004.
Wang, L., Johannessen, E. A., Hammond, P. A., Cui, L., Reid, S. W., Cooper, J. M., and Cumming, D. R., A programmable microsystem using system-on-chip for real-time biotelemetry. IEEE Trans Biomed Eng 52(7):1251–1260, 2005.
Khan, T., Shrestha, R., and Wahid, K., A Modular and Programmable Development Platform for Capsule Endoscopy System. Journal of Medical Systems 38(6):1–12, 2014.
Jiang, H., Li, F., Chen, X., Ning, Y., Zhang, X., Zhang, B., Ma, T., and Wang, Z., A SoC with 3.9 mW 3Mbps UHF transmitter and 240μW MCU for capsule endoscope with bidirectional communication. In: 2010 I.E. Asian Solid State Circuits Conference (A-SSCC), Beijing, IEEE, pp 1–4, 2010.
Pan, G., et al., Bleeding Detection in Wireless Capsule Endoscopy Based on Probabilistic Neural Network. Journal of Medical Systems 35(6):1477–1484, 2011.
Sainju, S., Bui, F. M., and Wahid, K. A., Automated bleeding detection in capsule endoscopy videos using statistical features and region growing. J Med Syst 38(4):1–11, 2014.
Li, B., and Meng, M.-H., Tumor recognition in wireless capsule endoscopy images using textural features and SVM-based feature selection. IEEE Trans Inf Technol Biomed 16(3):323–329, 2012.
Sasaki, Y., Hada, R., Nakajima, H., Fukuda, S., and Munakata, A., Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: colonic luminal pH in normal subjects and patients with Crohn’s disease. Am J Gastroenterol 92(1):114–118, 1997.
Pye, G., Evans, D., Ledingham, S., and Hardcastle, J., Gastrointestinal intraluminal pH in normal subjects and those with colorectal adenoma or carcinoma. Gut 31(12):1355–1357, 1990.
Kumar, D., and Wingate, D., The irritable bowel syndrome: a paroxysmal motor disorder. The Lancet 326(8462):973–977, 1985.
Yan, R., Yan, G., Zhang, W., and Wang, L., Long-range scaling behaviours of human colonic pressure activities. Commun Nonlinear Sci Numer Sim 13(9):1888–1895, 2008.
Van der Sijp, J., Kamm, M., Nightingale, J., Britton, K., Mather, S., Morris, G., Akkermans, L., and Lennard-Jones, J., Radioisotope determination of regional colonic transit in severe constipation: comparison with radio opaque markers. Gut 34(3):402–408, 1993.
Johannessen, E. A., Wang, L., Wyse, C., Cumming, D. R., and Cooper, J. M., Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments. IEEE Trans Biomed Eng 53(11):2333–2340, 2006.
Duroux, P., Emde, C., Bauerfeind, P., Francis, C., Grisel, A., Thybaud, L., Arstrong, D., Depeursinge, C., and Blum, A., The ion sensitive field effect transistor (ISFET) pH electrode: a new sensor for long term ambulatory pH monitoring. Gut 32(3):240–245, 1991.
Schwan, H. P., Electrical properties of tissue and cell suspensions. Adv Biol Med Phys 5:147, 1957.
Abouei, J., Plataniotis, K. N., and Pasupathy, S., Green modulations in energy-constrained wireless sensor networks. IET Commun 5(2):240–251, 2011.
Wang, W.-X., Yan, G.-Z., Sun, F., Jiang, P.-P., Zhang, W.-Q., and Zhang, G.-F., A non-invasive method for gastrointestinal parameter monitoring. World J Gastroentero 11(4):521–524, 2005.
Chirwa, L. C., Hammond, P. A., Roy, S., and Cumming, D. R., Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz. IEEE Trans Biomed Eng 50(4):484–492, 2003.
Acknowledgments
This research was supported by the National Nature Science Foundation of China under Contract 31170968.
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is part of the Topical Collection on Systems-Level Quality Improvement.
Rights and permissions
About this article
Cite this article
Zhao, K., Yan, G., Lu, L. et al. Low-Power Wireless Electronic Capsule for Long-Term Gastrointestinal Monitoring. J Med Syst 39, 9 (2015). https://doi.org/10.1007/s10916-015-0211-9
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10916-015-0211-9