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A Decision Tree Based Classifier to Analyze Human Ovarian Cancer cDNA Microarray Datasets

  • Transactional Processing Systems
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Abstract

Ovarian cancer is the deadliest gynaecological disease because of the high mortality rate and there is no any symptom in cancer early stage. It was often the terminal cancer period when patients were diagnosed with ovarian cancer and thus delays a good opportunity of treatment. The current common method for detecting ovarian cancer is blood testing for analyzing the tumor marker CA-125 of serum. However, specificity and sensitivity of CA-125 are insufficient for early detection. Therefore, it has become an urgent issue to look for an efficient method which precisely detects the tumor markers for ovarian cancer. This study aims to find the target genes of ovarian cancer by different algorithms of information science. Feature selection and decision tree were applied to analyze 9600 ovarian cancer-related genes. After screening the target genes, candidate genes will be analyzed by Ingenuity Pathway Analysis (IPA) software to create a genetic pathway model and to understand the interactive relationship in the different pathological stages of ovarian cancer. Finally, this research found 9 oncogenes associated with ovarian cancer and some genes had not been discovered in previous studies. This system will assist medical staffs in diagnosis and treatment at cancer early stage and improve the patient’s survival.

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Acknowledgments

The authors would like to thank the Ministry of Science and technology of Taiwan for Grants MOST-103-2622-E-005-022-CC3 and National Science Council of Taiwan for Grants NSC-102-2622-E-005-011-CC3 and NSC-102-2622-E-005-015-CC3 which supported part of this research.

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Authors and Affiliations

  1. Department of Management Information System, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan

    Meng-Hsiun Tsai, Hsin-Chieh Wang, Guan-Wei Lee & Yi-Chen Lin

  2. Institute of Genomics and Bioinformatics, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan

    Meng-Hsiun Tsai

  3. Troilus Bio-Technology Co. Ltd., Taiwan, Republic of China

    Sheng-Hsiung Chiu

Authors
  1. Meng-Hsiun Tsai
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  2. Hsin-Chieh Wang
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  3. Guan-Wei Lee
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  4. Yi-Chen Lin
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  5. Sheng-Hsiung Chiu
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Correspondence to Hsin-Chieh Wang.

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This article is part of the Topical Collection on Transactional Processing Systems

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Tsai, MH., Wang, HC., Lee, GW. et al. A Decision Tree Based Classifier to Analyze Human Ovarian Cancer cDNA Microarray Datasets. J Med Syst 40, 21 (2016). https://doi.org/10.1007/s10916-015-0361-9

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  • DOI: https://doi.org/10.1007/s10916-015-0361-9

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