Abstract
Eye disease is a major health problem among the elderly people. Cataract and corneal arcus are the major abnormalities that exist in the anterior segment eye region of aged people. Hence, computer-aided diagnosis of anterior segment eye abnormalities will be helpful for mass screening and grading in ophthalmology. In this paper, we propose a multiclass computer-aided diagnosis (CAD) system using visible wavelength (VW) eye images to diagnose anterior segment eye abnormalities. In the proposed method, the input VW eye images are pre-processed for specular reflection removal and the iris circle region is segmented using a circular Hough Transform (CHT)-based approach. The first-order statistical features and wavelet-based features are extracted from the segmented iris circle and used for classification. The Support Vector Machine (SVM) by Sequential Minimal Optimization (SMO) algorithm was used for the classification. In experiments, we used 228 VW eye images that belong to three different classes of anterior segment eye abnormalities. The proposed method achieved a predictive accuracy of 96.96% with 97% sensitivity and 99% specificity. The experimental results show that the proposed method has significant potential for use in clinical applications.







Similar content being viewed by others
References
Pascolini, D., and Mariotti, S. P., Global estimates of visual impairment: 2010. Br. J. Ophthalmol. 96(5):614–618, 2012.
Fernández, A., Sorokin, A., and Thompson, P. D., Corneal arcus as coronary artery disease risk factor. Atherosclerosis 193(2):235–240, 2007.
Macchiaiolo, M., Buonuomo, P. S., Valente, P., Rana, I., Lepri, F. R., Gonfiantini, M. V., and Bartuli, A., Corneal arcus as first sign of familial hypercholesterolemia. J. Pediatr. 164(3):670, 2014.
Moosavi, M., Sareshtedar, A., Zarei-Ghanavati, S., Zarei-Ghanavati, M., and Ramezanfar, N., Risk factors for senile corneal arcus in patients with acute myocardial infarction. J. Ophthalmic Vis. Res. 5(4):228–231, 2010.
Bansal, A., Agarwal, R., and Sharma, R. K., Determining diabetes using iris recognition system. Int. J. Diabetes Dev. Ctries. 35(4):432–438, 2015.
Lesmana, I. P. D., Purnama, I. K. E., and Purnomo, M. H., Abnormal condition detection of pancreatic beta-cells as the cause of diabetes mellitus based on iris image. In: 2nd International Conference on Instrumentation, Communication, Information Technology and Biomedical Engineering, Bandung, pp. 150–156. https://doi.org/10.1109/ICICI-BME.2011.6108614, 2011.
Zech, L. A., and Hoeg, J. M., Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia. Lipids Health Dis. 7:7. https://doi.org/10.1186/1476-511X-7-7. 2008.
Robinson, B. E., Prevalence of asymptomatic eye disease. Can. J. Optom. 65(5):175–180, 2003.
Zhang, Z., Srivastava, R., Liu, H., Chen, X., Duan, L., Kee Wong, D. W., Kwoh, C. K., Wong, T. Y., and Liu, J., A survey on computer aided diagnosis for ocular diseases. BMC Medical Informatics and Decision Making 14(1). https://doi.org/10.1186/1472-6947-14-80, 2014.
Marrugo, A., and Millán, M., Image analysis in modern ophthalmology: from acquisition to computer assisted diagnosis and telemedicine. Proc. SPIE 8436:84360C–1, 2012.
Ramlee, R. A., and Ranjit, S., Using iris recognition algorithm, detecting cholesterol presence. In: Proceedings - 2009 International Conference on Information Management and Engineering. ICIME 2009:714–717, 2009.
Wildes, R. P., Iris recognition: An emerging biometrie technology. Proc. IEEE 85(9):1348–1363, 1997.
Nasution, A., Fahdarina, S., and Cahya, D. I., System for quantifying the formation stages of corneal arcus. In: International Conference on Photonics Solutions 2015, 96590M (29 July 2015). https://doi.org/10.1117/12.2195903 2015.
Nasution, A., and Cahya, D. I., Development of Simple Digital Image Acquisition System for an Accurate Quantification of Corneal Arcus Formation. Appl. Mech. Mater. 771:112–115, 2015.
Mahesh Kumar, S. V., and Gunasundari, R., Diagnosis of corneal arcus using statistical feature extraction and support vector machine. Advances in Intelligent Systems and Computing. 394:481–492, 2016.
Acharya, U. R., Wong, L. Y., Ng, E. Y. K., and Suri, J. S., Automatic identification of anterior segment eye abnormality. Irbm. 28(1):35–41, 2007.
Acharya, R. U., Yu, W., Zhu, K., Nayak, J., Lim, T. C., and Chan, J. Y., Identification of cataract and post-cataract surgery optical images using artificial intelligence techniques. J. Med. Syst. 34(4):619–628, 2010.
Supriyanti, R., Habe, H., and Kidode, M., Utilization of Portable Digital Camera for Detecting Cataract, Ocular Diseases. INTECH, 2012. https://doi.org/10.5772/48428.
Nayak, J., Automated classification of normal, cataract and post cataract optical eye images using svm classifier. In: Proceedings of the World Congress on Engineering and Computer Science, pp 978–988, 2013.
Proenca, H., and Alexandre, L. A., UBIRIS : A noisy iris image database. Symp. A Q. J. Mod. Foreign Lit. 1:1–8, 2005.
Li, Y. H., and Savvides, M., An automatic iris occlusion estimation method based on high-dimensional density estimation. IEEE Trans. Pattern Anal. Mach. Intell. 35(4):784–796, 2013.
Shrivakshan, G. T., Chandrasekar, C., and Comparison, A., of various Edge Detection Techniques used in Image Processing. Int. J. Comput. Sci. Issues. 9(5):269–276, 2012.
Mallat, S. G., and Theory, A., for Multiresolution Signal Decomposition: The Wavelet Representation. IEEE Trans. Pattern Anal. Mach. Intell. 11(7):674–693, 1989.
Chowriappa, P., Dua, S., Kanno, J., and Thompson, H. W., Protein structure classification based on conserved hydrophobic residues. IEEE/ACM Trans. Comput. Biol. Bioinforma. 6(4):639–651, 2009.
Üstün, B., Melssen, W., and Buydens, L., Facilitating the application of Support Vector Regression by using a universal Pearson VII function based kernel. Chemom. Intell. Lab. Syst. 81(1):29–40, 2006.
Platt, J. C., Fast training of support vector machines using sequential minimal optimization. In: Advances in kernel methods, MIT Press, Cambridge, MA, pp. 185–208, 1999.
Keerthi, S. S., Shevade, S. K., Bhattacharyya, C., and Murthy, K. R. K., Improvements to Platt’s SMO Algorithm for SVM Classifier Design. Neural Comput. 13(3):637–649, 2001.
Hastie, T., and Tibshirani, R., Classification by pairwise coupling. Ann. Stat. 26(2):451–471, 1998.
Acknowledgments
We would like to thank Dr. N. Ezhilvathani, Head, Department of Ophthalmology, Indira Gandhi Medical College and Research Institute (IGMC&RI), Puducherry for her valuable suggestions and support during the eye image data collection process of this research work.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
None declared.
Informed Consent
This study was approved by the Director of the medical review board, Indira Gandhi Medical College and Research Institute, Puducherry. Also, the informed written consent form was obtained from all individual volunteers participated in this study.
Additional information
This article is part of the Topical Collection on Image & Signal Processing
Rights and permissions
About this article
Cite this article
S.V., M., R., G. Computer-Aided Diagnosis of Anterior Segment Eye Abnormalities using Visible Wavelength Image Analysis Based Machine Learning. J Med Syst 42, 128 (2018). https://doi.org/10.1007/s10916-018-0980-z
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10916-018-0980-z