Abstract
Accurate recognition of cervical cancer cells is of great significance to clinical diagnosis, but these existing algorithms are designed by low-level manual feature, and their performance improvements are limited an improved algorithm based on residual neural network is proposed to improve the accuracy of diagnosis. Firstly, momentum parameters are introduced into the training model; secondly, by changing the number of training samples, the recognition rate of the algorithm can be improved. Therefore, aiming at the task of object recognition under resource constrained condition, we optimize the design method of the network structure such as convolution operation, model parameter compression and enhancement of feature expression depth, and design and implement the lightweight network model structure for embedded platform. Our proposed deep network model can reduce the parameters of the model and the resources needed for operation under the condition of guaranteeing the precision. The experimental results show that the lightweight deep model has better performance than that of the existing comparison models, and it can achieve the model accuracy of 94.1% under the condition that the model with fewer parameters on cervical cells data set.






Similar content being viewed by others
References
Chiang, Y., Chou, C. Y., Hsu, K. F. et al., EGF upregulates Na+/H+ exchanger NHE1 by post-translational regulation that is important for cervical cancer cell invasiveness [J]. Journal of Cellular Physiology 2010, 214(3):810–819.
Sokouti, B., Haghipour, S., and Tabrizi, A. D., A framework for diagnosing cervical cancer disease based on feedforward MLP neural network and ThinPrep histopathological cell image features[J]. Neural Computing and Applications 24(1):221–232, 2014.
Chan, S. W., Leung, K. S., and Wong, W. S., An expert system for the detection of cervical cancer cells using knowledge-based image analyzer [J]. Artificial Intelligence in Medicine 8(1):67, 1996.
Tang, Z., Wang, S., Huo, J., et al. Bayesian Framework with Non-local and Low-rank Constraint for Image Reconstruction[C]// Journal of Physics Conference Series. 1–12, 2017.
Sokouti, B., Haghipour, S., and Tabrizi, A., A pilot study on image analysis techniques for extracting early uterine cervix cancer cell features.[J]. Journal of Medical Systems 36(3):1901–1907, 2012.
Schilling, T., Miroslaw, L., Glab, G. et al., Towards rapid cervical cancer diagnosis: Automated detection and classification of pathologic cells in phase-contrast images.[J]. International Journal of Gynecological Cancer 17(1):118–126, 2010.
Nguyen, N. G., Poulsen, R. S., and Louis, C., Some new color features and their application to cervical cell classification[J]. Pattern Recognition 16(4):401–411, 1983.
Zhao, L., Li, K., Yin, J. et al., Complete three-phase detection framework for identifying abnormal cervical cells[J]. IET Image Processing 11(4):258–265, 2017.
Bacus, J. W., Cervical cell recognition and morphometric grading by image analysis[J]. Journal of Cellular Biochemistry 59(23):12–21, 2010.
Tseng, C. J., Lu, C. J., and Chang, C.-C., Application of machine learning to predict the recurrence-proneness for cervical cancer[J]. Neural Computing & Applications 24(6):1311–1316, 2014.
Long, N. P., Jung, K. H., Yoon, S. J. et al., Systematic assessment of cervical cancer initiation and progression uncovers genetic panels for deep learning-based early diagnosis and proposes novel diagnostic and prognostic biomarkers.[J]. Oncotarget 88(65):1094–1136, 2017.
Zhang, L., Sonka, M., Lu, L., et al. combining fully convolutional networks and graph-based approach for automated segmentation of cervical cell nuclei[C]// IEEE International Symposium on Biomedical Imaging. IEEE, 112–123, 2017.
Zhang, L., Lu, L., Nogues, I., et al. DeepPap: Deep Convolutional Networks for Cervical Cell Classification[J]. IEEE Journal of Biomedical and Health Informatics, 1–12, 2017.
Valdes, G., and Interian, Y., Comment on \"deep convolutional neural network with transfer learning for rectum toxicity prediction in cervical cancer radiotherapy: A feasibility study\"[J]. Physics in Medicine and Biology 12(1):231–233, 2018.
Liu, Y., Zhang, P., Song, Q. et al., Automatic segmentation of cervical nuclei based on deep learning and a conditional random field[J]. IEEE Access 24(23):1–17, 2018.
Tareef, A., Song, Y., Huang, H. et al., Optimizing the cervix cytological examination based on deep learning and dynamic shape modeling[J]. Neurocomputing 33(25):231–237, 2017.
Huang, X., Wang, J., Tang, F. et al., Metal artifact reduction on cervical CT images by deep residual learning[J]. BioMedical Engineering OnLine 17(1):787–798, 2018.
Sornapudi, S., Stanley, R. J., Stoecker, W., et al. Deep Learning Nuclei Detection in Digitized Histology Images by Superpixels[J]. Journal of Pathology Informatics, 2018.
Sato, M., Horie, K., Hara, A. et al., Application of deep learning to the classification of images from colposcopy[J]. Oncology Letters 12:11):1–11):4, 2018.
Song, Y., Zhang, L., Chen, S. et al., Accurate segmentation of cervical cytoplasm and nuclei based on multiscale convolutional network and graph partitioning[J]. IEEE Transactions on Biomedical Engineering 62(10):2421–2433, 2015.
Phoulady, H. A., Mouton, P. R.. A New Cervical Cytology Dataset for Nucleus Detection and Image Classification (Cervix93) and Methods for Cervical Nucleus Detection[J]. arXiv: Computer Vision and Pattern Recognition, 2018.
Bora K, Chowdhury M, Mahanta L B, et al. Pap smear image classification using convolutional neural network[C]// Tenth Indian Conference on Computer Vision. 10287–10296, 2016.
Cho, Y. H., and Mangione-Smith, W. H., Deep network packet filter design for reconfigurable devices[J]. ACM Transactions on Embedded Computing Systems 7(2):1–26, 2008.
Kim, K. H., Hong, S., Roh, B., et al. PVANET: Deep but Lightweight Neural Networks for Real-time Object Detection[J]. arXiv: Computer Vision and Pattern Recognition, 2016.
Xia, K., Wang, J., Wu, Y., Robust Alzheimer Disease classification based on Feature Integration Fusion Model for Magnetic[J]Journal of medical imaging and health informatics, 7, 1-6, 2017.
Kai-jian Xia, Hong-sheng Yin, Yu-dong Zhang. Deep Semantic Segmentation of Kidney and Space-Occupying Lesion Area Based on SCNN and ResNet Models Combined with SIFT-Flow Algorithm. Journal of medical systems, (2019) 43:2 https://doi.org/10.1007/s10916-018-1116-1.
Ma, N., Zhang, X., Zheng, H. T., et al. ShuffleNet V2: Practical Guidelines for Efficient CNN Architecture Design[J]. 31(28):10392–10402, 2018.
Chen T, Lin L, Zuo W, et al. Learning a Wavelet-like Auto-Encoder to Accelerate Deep Neural Networks[J]. 22(12):12–21., 2017
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
We declare that we have no conflict of interest.
Ethical approval
The paper does not contain any studies with human participants or animals performed by any of the authors.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Image & Signal Processing
Rights and permissions
About this article
Cite this article
Wang, H., Jiang, C., Bao, K. et al. Recognition and Clinical Diagnosis of Cervical Cancer Cells Based on our Improved Lightweight Deep Network for Pathological Image. J Med Syst 43, 301 (2019). https://doi.org/10.1007/s10916-019-1426-y
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10916-019-1426-y