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Aberrant functional connectivity in patients with obstructive sleep apnea-hypopnea syndrome: a resting-state functional MRI study

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Abstract

The objective of this study was to investigate the change in the default mode network (DMN) in subjects with obstructive sleep apnea-hypopnea syndrome (OSAHS) using resting-state functional connectivity (rsFC). Functional magnetic resonance imaging (rs-fMRI) data were collected from twenty-nine subjects with OSAHS and twenty-six normal controls. The data were analyzed with the rsFC method and were compared between OSAHS subjects and controls. The Z-values of abnormal rsFC in different brain regions were correlated with clinical variables, including the apnea-hypopnea index (AHI), oxygen desaturation index (ODI), Epworth sleepiness scale (ESS), Rey-osterrieth complex figure test (CFT-immediately), CFT-delay, Logical memory test-immediately (LMT-immediately), LMT-delay and Minimum mental state examination (MMSE). The rsFC showed significant increases in the left temporal cortex, right midfrontal cortex, and left precuneus cortex as well as decreases in the bilateral inferior parietal lobule (IPL), left medial prefrontal cortex (MPFC), left superior frontal cortex and right cerebellum in patients with OSAHS. The FC strength in the left precuneus showed a remarkable positive correlation with ODI(p = .032, r = .399)and CFT-delay scores (p = .043, r = .378). We found that the FC strength in the right cerebellum was positively correlated with the CFT-delay scores (p = .017, r = .441). FC strength in the right cerebellum and left IPL demonstrated a remarkable positive correlation with LMT-delay scores (p = .037,r = .389;p = .043 and r = .379, respectively). However, there was a strong negative correlation between the left MPFC region and ESS scores (p = .032, r = −.398). The abnormal rsFC in subjects with OSAHS indicated the compensatory change of brain function, which possibly provides an innovative approach and perspective on understanding the neural mechanism alteration of OSAHS-related cognition.

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Acknowledgments

This paper was supported by the Clinical Medical Science and Technology Special Project of Jiangsu,China(NO. BL2013029) and was partly supported by the Maternity and Child Care Project, Jiangsu Province,China(F201554), Science and Technology Development Project, Nanjing, China (2015sc511023) and Six Talent Peaks Project in Jiangsu Province (WSN-192),China.

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Authors and Affiliations

  1. Department of Radiology, Zhongda Hospital, SEU (Southeast University), Nanjing, 210009, China

    Ting Chen, Ya-Qing Huang, Hui-Xin Zhang & Bin Liu

  2. Medical School of SEU, Nanjing, 210009, China

    Yu -Ting Liu

  3. Department of Radiology, Children’s Hospital, Nanjing Medical University, Nanjing, 210008, China

    Hui-Jun Li & Ming Yang

  4. Department of Otolaryngology-Head and Neck Surgery, Zhongda Hospital, SEU, Nanjing, 210009, China

    Lian Zhang & Zhi-chun Huang

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Yu-Ting Liu and Hui-Jun Li contributed equally to this work.

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Liu, Y.T., Li, HJ., Chen, T. et al. Aberrant functional connectivity in patients with obstructive sleep apnea-hypopnea syndrome: a resting-state functional MRI study. Multimed Tools Appl 77, 4065–4079 (2018). https://doi.org/10.1007/s11042-017-4670-5

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