Abstract
Retinopathy of prematurity (ROP) is a retinal vascular proliferative disease principally observed in infants born prematurely with low birth weight. ROP is the leading cause of childhood blindness. Early screening and timely treatment are crucial in preventing ROP blindness. Previous ROP diagnosis lacks clear understanding of the underlying factors and properties that supports the final decision. For this reason, a deep convolutional neural network (DCNN) is developed for automated ROP detection using wide-angle retinal images. Specifically, we first choose ResNet50 as our base architecture and improve the ResNet by adding a channel and a spatial attention module. Then, we utilize a class-discriminative localization technique (i.e., gradient-weighted class activation mapping (Grad-CAM)) to visualize the trained models and realize pathological structure localization. The efficacy of the proposed network is evaluated on two test datasets. Our method obtains a sensitivity of 94.84 % and a specificity of 99.49 % on test set 1 while a sensitivity of 98.03 % and a specificity of 94.55 % on test set 2. Also, the model successfully detects the pathological structures of ROP (e.g., demarcation lines or ridges) in the retina images.
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Acknowledgements
This work was supported partly by Shenzhen Key Medical Discipline Construction Fund (No. SZXK038), Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties (No.SZGSP014), Shenzhen-Hong Kong Co-financing Project (No.SGDX20190920110403741), and Guangdong Basic and Applied Basic Research Foundation (No. 2019A1515111205).
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Lei, B., Zeng, X., Huang, S. et al. Automated detection of retinopathy of prematurity by deep attention network. Multimed Tools Appl 80, 36341–36360 (2021). https://doi.org/10.1007/s11042-021-11208-0
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DOI: https://doi.org/10.1007/s11042-021-11208-0