Abstract
Lung-related ailments are prevalent all over the world which majorly includes asthma, chronic obstructive pulmonary disease (COPD), tuberculosis, pneumonia, fibrosis, etc. and now COVID-19 is added to this list. Infection of COVID-19 poses respirational complications with other indications like cough, high fever, and pneumonia. WHO had identified cancer in the lungs as a fatal cancer type amongst others and thus, the timely detection of such cancer is pivotal for an individual’s health. Since the elementary convolutional neural networks have not performed fairly well in identifying atypical image types hence, we recommend a novel and completely automated framework with a deep learning approach for the recognition and classification of chronic pulmonary disorders (CPD) and COVID-pneumonia using Thoracic or Chest X-Ray (CXR) images. A novel three-step, completely automated, approach is presented that first extracts the region of interest from CXR images for preprocessing, and they are then used to detects infected lungs X-rays from the Normal ones. Thereafter, the infected lung images are further classified into COVID-pneumonia, pneumonia, and other chronic pulmonary disorders (OCPD), which might be utilized in the current scenario to help the radiologist in substantiating their diagnosis and in starting well in time treatment of these deadly lung diseases. And finally, highlight the regions in the CXR which are indicative of severe chronic pulmonary disorders like COVID-19 and pneumonia. A detailed investigation of various pivotal parameters based on several experimental outcomes are made here. This paper presents an approach that detects the Normal lung X-rays from infected ones and the infected lung images are further classified into COVID-pneumonia, pneumonia, and other chronic pulmonary disorders with an utmost accuracy of 96.8%. Several other collective performance measurements validate the superiority of the presented model. The proposed framework shows effective results in classifying lung images into Normal, COVID-pneumonia, pneumonia, and other chronic pulmonary disorders (OCPD). This framework can be effectively utilized in this current pandemic scenario to help the radiologist in substantiating their diagnosis and in starting well in time treatment of these deadly lung diseases.

















Similar content being viewed by others
References
Apostolopoulos ID, Mpesiana TA (2020) Covid-19: automatic detection from x-ray images utilizing transfer learning with convolutional neural networks. Phys Eng Sci Med 1
Baker JA, Rosen EL, Lo JY, Gimenez EI, Walsh R, Soo MS (2003) Computer-aided detection (CAD) in screening mammography: sensitivity of commercial CAD systems for detecting architectural distortion. Am J Roentgenol 181(4):1083–1088
Barrientos F, Roman-Gonzalez A, Barrientos R, Solis L, Alva A, Correa M, ..., Oberhelman R (2016) Filtering of the skin portion on lung ultrasound digital images to facilitate automatic diagnostics of pneumonia. In 2016 IEEE 36th Central American and Panama Convention (CONCAPAN XXXVI) (pp. 1–4). IEEE
Barrientos R, Roman-Gonzalez A, Barrientos F, Solis L, Correa M, Pajuelo M, ..., Checkley W (2016) Automatic detection of pneumonia analyzing ultrasound digital images. In 2016 IEEE 36th Central American and Panama Convention (CONCAPAN XXXVI) (pp. 1–4). IEEE
Behzadi-khormouji H et al (2019) Deep learning, reusable and problem based architectures for detection of consolidation on chest X-ray images. Comput Methods Progr Biomed. https://doi.org/10.1016/j.cmpb.2019.105162
Bhandary Abhir et al (2020) Deep-learning framework to detect lung abnormality – a study with chest X-Ray and lung CT scan images. Pattern Recogn Lett 129:271–8. https://doi.org/10.1016/j.patrec.2019.11.013
Bharati S, Podder P, Paul PK (2019) Lung cancer recognition and prediction according to random forest ensemble and RUSBoost algorithm using LIDC data. Int J Hybrid Intell Syst 15(2):91–100. https://doi.org/10.3233/HIS-190263
Cheng JZ, Ni D, Chou YH, Qin J, Tiu CM, Chang YC, ..., Chen CM (2016) Computer-aided diagnosis with deep learning architecture: applications to breast lesions in US images and pulmonary nodules in CT scans. Sci Rep 6(1): 1-13
Cheng YT, Lin YF, Chiang KH, Tseng VS (2017) Mining sequential risk patterns from large-scale clinical databases for early assessment of chronic diseases: a case study on chronic obstructive pulmonary disease. IEEE J Biomed Health Inf 21:303–311
Chouhan V et al (2020) A novel transfer learning based approach for pneumonia detection in chest X-ray images. Appl Sci 10(2):559. https://doi.org/10.3390/app10020559
Cisneros-Velarde P, Correa M, Mayta H, Anticona C, Pajuelo M, Oberhelman R, ..., Lavarello R (2016) Automatic pneumonia detection based on ultrasound video analysis. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 4117–4120). IEEE
COVID-19 Mortality Rates by Age and Gender: Why Is the Disease Killing More Men than Women? (n.d.). Retrieved December 3, 2020, from https://www.rgare.com/knowledge-center/media/research/covid-19-mortality-rates-by-age-and-gender-why-is-the-disease-killing-more-men-than-women
Datta P, Gupta A, Agrawal R (2014) Statistical modeling of B-Mode clinical kidney images. In 2014 International Conference on Medical Imaging, m-Health and Emerging Communication Systems (MedCom) (pp. 222–229). IEEE
Doi K (2007) Computer-aided diagnosis in medical imaging: historical review, current status and future potential. Comput Med Imaging Graph 31(4–5):198–211
Eshaghi H, Ziaee V, Khodabande M, Safavi M, Haji Esmaeil Memar E (2021) Clinical Misdiagnosis of COVID-19 Infection with Confusing Clinical Course. Case Rep Infect Dis 2021https://doi.org/10.1155/2021/6629966
Gu Y, Lu X, Yang L, Zhang B, Yu D, Zhao Y, Gao L, Wu L, Zhou T (2018) Automatic lung nodule detection using a 3D deep convolutional neural network combined with a multi-scale prediction strategy in chest CTs. Comput Biol Med 103:220–231
He K, Gkioxari G, Dollar P, Girshick R. Mask r-cnn. Proceedings of the IEEE International Conference on Computer Vision 2017:2961–9
Hemdan EED, Shouman MA, Karar ME (2020) Covidx-net: A framework of deep learning classifiers to diagnose covid-19 in x-ray images. arXiv preprint arXiv:2003.11055
Hina K, Khalid S, Akbar MU (2016) A review on automatic tuberculosis screening using chest radiographs. In 2016 Sixth International Conference on Innovative Computing Technology (INTECH) (pp. 285–289). IEEE
Horváth G, Orbán G, Horváth Á, Simkó G, Pataki B, Máday P, Juhász S (2009) A cad system for screening x-ray chest radiography. In World Congress on Medical Physics and Biomedical Engineering, September 7-12, 2009, Munich, Germany (pp. 210-213). Springer, Berlin, Heidelberg
Huang J, Rathod V, Sun C, Zhu M, Korattikara A, Fathi A, Fischer I, Wojna Z, Song Y, Guadarrama S, et al. Speed/accuracy trade-offs for modern convolutional object detectors. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition 2017:7310–1
Irvin J, Rajpurkar P, Ko M, Yu Y, Ciurea-Ilcus S, Chute C, Marklund H, Haghgoo B, Ball r, Shpanskaya K, et al. Chexpert: a large chest radiograph dataset with uncertainty labels and expert comparison. 2019. arXiv:1901.07031
Jaiswal A, Gianchandani N, Singh D, Kumar V, Kaur M (2020) Classification of the COVID-19 infected patients using DenseNet201 based deep transfer learning. J Biomol Struct Dyn 1-8. https://doi.org/10.1080/07391102.2020.1788642
Kallianos K, Mongan J, Antani S et al (2019) How far have we come? Artificial intelligence for chest radiograph interpretation. Clin Radiol 74(5):338–345. https://doi.org/10.1016/j.crad.2018.12.015
Karargyris A, Antani S, Thoma G (2011) Segmenting anatomy in chest x-rays for tuberculosis screening. In 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 7779–7782). IEEE
Khan AI, Shah JL, Bhat MM (2020) CoroNet: A deep neural network for detection and diagnosis of COVID-19 from chest x-ray images. Comput Methods Programs Biomed 196:105581. https://doi.org/10.1016/j.cmpb.2020.105581
Krizhevsky A, Sutskever I, Hinton GE (2017) Imagenet classification with deep convolutional neural networks. Commun ACM 60(6):84–90
Kuan K, Ravaut M, Manek G, Chen H, Lin J, Nazir B, Chen C, Howe TC, Zeng Z, Chandrasekhar V (2017) Deep learning for lung cancer detection: tackling the Kaggle data science bowl 2017 challenge. https://arxiv.org/abs/1705.09435. Accessed 12 Dec 2020
Liang C-H et al (2019) Identifying pulmonary nodules or masses on chest radiography using deep learning: external validation and strategies to improve clinical practice. Clin Radiol. https://doi.org/10.1016/j.crad.2019.08.005
Liu J, Pan Y, Li M, Chen Z, Tang L, Lu C, Wang J (2018) Applications of deep learning to MRI images: A survey. Big Data Mining and Analytics 1(1):1–18
Lundervold AS, Lundervold A (2019) An overview of deep learning in medical imaging focusing on MRI. Z Med Phys 29(2):102–127
Mehrotra R, Ansari MA, Agrawal R, Anand RS (2020) A Transfer Learning approach for AI-based classification of brain tumors. Mach Learn Appl 2:100003
Mohammed MA, Abdulkareem KH, Garcia-Zapirain B, Mostafa SA, Maashi MS, Al-Waisy AS, ..., Le DN (2020) A comprehensive investigation of machine learning feature extraction and classification methods for automated diagnosis of covid-19 based on x-ray images. Comput Mater Continua 66(3)
Mondal MRH, Bharati S, Podder P, Podder P. "Data analytics for novel coronavirus disease", informatics in medicine unlocked, 20. Elsevier; 2020. p. 100374. https://doi.org/10.1016/j.imu.2020.100374
Murray CJL, Lopez AD (1997) Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet 349:1498–1504
Nasrullah N, Sang J, Alam MS, Xiang H. Automated detection and classification for early stage lung cancer on CT images using deep learning. Proc SPIE 13 May 2019; 10995:109950S. Pattern Recognition and Tracking XXX
Nielsen KG, Bisgaard H (2005) The effect of inhaled budesonide on symptoms, lung function, and cold air and methacholine responsiveness in 2- to 5-year-old asthmatic children. Am J Respir Crit Care Med 162:1500–1506
NIH sample Chest X-rays dataset. https://www.kaggle.com/nih-chest-xrays/sa mple. [Accessed 28 June 2020]
Pan SJ, Yang Q (2009) A survey on transfer learning. IEEE Trans Knowl Data Eng 22(10):1345–1359
Ren S, He K, Girshick R, Sun J. Faster r-cnn: towards real-time object detection with region proposal networks. Adv Neural Inf Process Syst 2015:91–9. 6th ACM conference on bioinformatics, computational biology and health informatics. Atlanta, GA, USA: ACM; 2015. p. 258–67
Ronneberger O, Fischer P, Brox T (2015) U-net: convolutional networks for biomedical image segmentation. In: International conference on medical image computing and computer-assisted intervention, vol. 9351. Berlin/Heidelberg, Germany: Springer p. 234–41
Sethy PK, Behera SK (2020) Detection of coronavirus disease (covid-19) based on deep features. Preprints 2020030300:2020
Setio AAA, Traverso A, de Bel T, Berens MSN, van den Bogaard C, Cerello P, Chen H, Dou Q, Fantacci ME, Geurts B et al (2017) Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: the LUNA16 challenge. Med Image Anal 42:1–13
Shelhamer E, Long J, Darrell T (2017) Fully convolutional networks for semantic segmentation. IEEE Trans Pattern Anal Mach Intell 39(4):640–651. https://doi.org/10.1109/TPAMI.2016.2572683
Shrivastava A, Sukthankar R, Malik J, Gupta A. Beyond skip connections: topdown modulation for object detection. 2017. arXiv:1612.06851
Song Q, Zhao L, Luo X, Dou X (2017) Using deep learning for classification of lung nodules on computed tomography images. J Healthc Eng 8314740. https://doi.org/10.1155/2017/8314740
Song Y, Zheng S, Li L, Zhang X, Zhang X, Huang Z, ..., Chong Y (2020) Deep learning enables accurate diagnosis of novel coronavirus (COVID-19) with CT images. medRxiv
Sun W, Zheng B, Qian W (2016) Computer aided lung cancer diagnosis with deep learning algorithms. In: Proc SPIE. Medical Imaging, 2016, 9785. Computer-Aided Diagnosis 97850Z. https://doi.org/10.1117/12.2216307
Sun W, Zheng B, Qian W (2017) Automatic feature learning using multichannel ROI based on deep structured algorithms for computerized lung cancer diagnosis. Comput Biol Med 89:530–539
Tuberculosis Chest X-ray Image Data Sets. - LHNCBC Abstract. Available at: https://lhncbc.nlm.nih.gov/LHC-publications/pubs/TuberculosisChestXrayImageDataSets.html (Accessed: 16 August 2021)
Van der Burgh HK, Schmidt R, Westeneng HJ, de Reus MA, van den Berg LH, van den Heuvel MP (2017) Deep learning predictions of survival based on MRI in amyotrophic lateral sclerosis. NeuroImage: Clinical 13:361–369
Vieira SM, Kaymak U, Sousa JM (2010) Cohen's kappa coefficient as a performance measure for feature selection. In International Conference on Fuzzy Systems (pp. 1–8). IEEE
Wang L, Wong A (2020) COVID-Net: A Tailored Deep Convolutional Neural Network Design for Detection of COVID-19 Cases from Chest X-Ray Images. arXiv preprint arXiv:2003.09871
World Lung Day 2019: Healthy Lungs for All - Global Initiative for Chronic Obstructive Lung Disease – GOLD, https://goldcopd.org/world-lung-day-2019-healthy-lungs-for-all/. Accessed 27 Nov 2020
Yamashita R, Nishio M, Do RKG, Togashi K (2018) Convolutional neural networks: an overview and application in radiology. Insights Imaging 9(4):611–629
Zenteno O, Castañeda B, Lavarello R (2016) Spectral-based pneumonia detection tool using ultrasound data from pediatric populations. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 4129–4132). IEEE
Zhou, Bolei, Aditya Khosla, Agata Lapedriza, Aude Oliva, and Antonio Torralba. "Learning deep features for discriminative localization." In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2921–2929. 2016
Zhu W, Liu C, Fan W, Xie X (2018) DeepLung. Deep 3D dual path nets for automated pulmonary nodule detection and classification. In: Proceedings of the IEEE winter conference on applications of computer vision (WACV); 12–15 March. p. 673–81. Lake Tahoe, NV, USA
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Mehrotra, R., Agrawal, R. & Ansari, M.A. Diagnosis of hypercritical chronic pulmonary disorders using dense convolutional network through chest radiography. Multimed Tools Appl 81, 7625–7649 (2022). https://doi.org/10.1007/s11042-021-11748-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11042-021-11748-5