Abstract
Segmenting histopathological image automatically is an important task in computer-aided pathology analysis. However, it is challenging to segment and analyze digitalized histopathology images due to the large size of WSI, diversity and complexity of features. In this paper, we propose a multi-resolution attention and multi-scale convolution network (MAMC-Net) for the automatic tumor segmentation of WSI. First, the proposed MAMC-Net design the multi-resolution attention module that utilizes multi-resolution images as the pyramid inputs to generate a wider range feature information and richer details. Specifically, we employ an attention mechanism at each level to capture discriminative features related with the segmentation task. Furthermore, a multi-scale convolution module is designed to multi-scale feature representation by aggregating intact semantic information from the deep layer of encoder and high-resolution details from the final layer of decoder. To further obtain the accurate segmentation results, we adopt a fully connected Conditional Random Field (CRF) to splice the overlapping maps to avoid discontinuities and inconsistencies of cancer boundaries. Finally, we demonstrate the effectiveness of our framework on open-source datasets, including CAME-LYON17 (breast cancer metastases) and BOT (gastric cancer) datasets. The experimental results show that our proposed MAMC-Net obtains superior performance compared with other state-of-the-art methods, such as a Dice coefficient (DSC) of 0.929, an IOU score of 0.867, recall of 0.933 on the breast cancer dataset, a Dice coefficient (DSC) of 0.89, an IOU score of 0.802, recall of 0.903 on the gastric cancer dataset.
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All the data generated or analyzed during this study is included in this published article. The datasets used or analyzed during the current study are available from the official website or the corresponding author on reasonable request.
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Acknowledgements
This article was supported by Natural Science Foundation of Hunan Province in China (2020JJ4588, 2020JJ4090), Joint Fund for Regional Innovation and Development of National Natural Science Foundation in China (U19A2083), and Open Project of Key Laboratory of Intelligent Computing and Information Processing of Ministry of Education, Xiangtan University (2020ICIP06). We would especially like to thank Associate Professor Chaoyang Ai for his contributions to the English revision of this manuscript.
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Li Zeng and Wei Wang are contributed equally to this work.
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Zeng, L., Tang, H., Wang, W. et al. MAMC-Net: an effective deep learning framework for whole-slide image tumor segmentation. Multimed Tools Appl 82, 39349–39369 (2023). https://doi.org/10.1007/s11042-023-15065-x
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DOI: https://doi.org/10.1007/s11042-023-15065-x