Skip to main content
Log in

Ensuring authentication in Medical Cyber-Physical Systems: A comprehensive literature review of blockchain technology integration with machine learning

  • Published:
Multimedia Tools and Applications Aims and scope Submit manuscript

Abstract

Medical Cyber-Physical Systems (MCPS) are increasingly prevalent in an era of rapid technological advancement. They hold significant importance for patients and healthcare professionals, as they leverage cyber-physical systems (CPS). These systems generate substantial amounts of big data, posing challenges for processing and storage. Furthermore, they face vulnerabilities to cyber-attacks. With multiple parties involved, concerns arise regarding authentication processes and safeguarding against unauthorized access. To address these issues, Blockchain technology is employed to enhance system authentication and protect medical data. The integration of Blockchain and machine learning further improves the efficiency of big data processing in MCPS. This paper provides a comprehensive review of recent studies focusing on the integration of Blockchain technology with Medical Cyber-Physical Systems (MCPS) and its application in the medical field. The reviewed studies shed light on various aspects of utilizing Blockchain to enhance the security and efficiency of MCPS and protect medical data. Through these studies, several unresolved weaknesses, concerns and proposed solutions have been identified in the integration of Blockchain with Medical Cyber-Physical Systems (MCPS).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

Data availability

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

References

  1. Qiu H et al (2020) Secure health data sharing for medical cyber-physical systems for the healthcare 40. IEEE J Biomed Health Inform 24(9):2499–2505

    Article  Google Scholar 

  2. F Chen F et al (2021) Medical cyber-physical systems: A solution to smart health and the state of the art. IEEE Transactions on Computational Social Systems.

  3. Cheng X et al (2020) Design of a secure medical data sharing scheme based on blockchain. J Med Syst 44(2):1–11

    Article  Google Scholar 

  4. Tyagi AK et al (2021) AARIN: Affordable, accurate, reliable and innovative mechanism to protect a medical cyber-physical system using blockchain technology. Int J Intell Netw 2:175–183

    Google Scholar 

  5. Gatouillat A et al (2018) Internet of medical things: A review of recent contributions dealing with cyber-physical systems in medicine. IEEE Internet Things J 5(5):3810–3822

    Article  Google Scholar 

  6. Xi P et al (2022) A Review of Blockchain-Based Secure Sharing of Healthcare Data. Appl Sci 12(15):7912

    Article  Google Scholar 

  7. Zhao W et al (2020) Blockchain-enabled cyber–physical systems: A review. IEEE Internet Things J 8(6):4023–4034

    Article  Google Scholar 

  8. Rathore H, Mohamed A, Guizani M (2020) A survey of blockchain enabled cyber-physical systems. Sensors 20(1):282

    Article  Google Scholar 

  9. Salah K et al (2019) Blockchain for AI: Review and open research challenges. IEEE Access 7:10127–10149

    Article  Google Scholar 

  10. Shafay M et al (2022) Blockchain for deep learning: review and open challenges. Cluster Comput 1–25

  11. Nair MM, Tyagi AK, Goyal R (2019) Medical cyber physical systems and its issues. Procedia Comput Sci 165:647–655

    Article  Google Scholar 

  12. Lee I, O Sokolsky (2020) Medical cyber physical systems. in Design automation conference. IEEE.

  13. Hassan MU, Rehmani MH, Chen J (2019) Differential privacy techniques for cyber physical systems: a survey. IEEE Commun Surv Tutorials 22(1):746–789

    Article  Google Scholar 

  14. Kocabas O, Soyata T, Aktas MK (2016) Emerging security mechanisms for medical cyber physical systems. IEEE/ACM Trans Comput Biol Bioinf 13(3):401–416

    Article  Google Scholar 

  15. Priyadarshini I et al (2021) A new enhanced cyber security framework for medical cyber physical systems. SICS Software-Intensive Cyber-Phys Syst 35(3):159–183

    Google Scholar 

  16. Dedeoglu V et al (2020) A journey in applying blockchain for cyberphysical systems. in 2020 International Conference on COMmunication Systems & NETworkS (COMSNETS). IEEE.

  17. Tadaka SM (2020) Applications of Blockchain in Healthcare, Industry 4, and Cyber-Physical Systems. in 2020 7th International Conference on Internet of Things: Systems, Management and Security (IOTSMS). IEEE.

  18. Dang LM et al (2019) A survey on internet of things and cloud computing for healthcare. Electronics 8(7):768

    Article  Google Scholar 

  19. Syed TA et al (2019) A comparative analysis of blockchain architecture and its applications: Problems and recommendations. IEEE Access 7:176838–176869

    Article  Google Scholar 

  20. Dell JT, Greiner W, Rosenstiel (2014) Model-based platform design and evaluation of cloud-based cyber-physical systems (CCPS). in 2014 12th IEEE international conference on industrial informatics (INDIN). IEEE.

  21. Verma R (2022) Smart city healthcare cyber physical system: characteristics, technologies and challenges. Wireless Pers Commun 122(2):1413–1433

    Article  Google Scholar 

  22. Xu X, Weber I, Staples M (2019) Design process for applications on blockchain. Architecture for Blockchain Applications. Springer, pp 93–111

    Chapter  Google Scholar 

  23. Imran M et al (2021) Comprehensive survey of iot, machine learning, and blockchain for health care applications: A topical assessment for pandemic preparedness, challenges, and solutions. Electronics 10(20):2501

    Article  Google Scholar 

  24. Pereira A, Thomas C (2020) Challenges of machine learning applied to safety-critical cyber-physical systems. Machine Learn Knowl Extraction 2(4):579–602

    Article  Google Scholar 

  25. Shickel B et al (2017) Deep EHR: a survey of recent advances in deep learning techniques for electronic health record (EHR) analysis. IEEE J Biomed Health Inform 22(5):1589–1604

    Article  Google Scholar 

  26. Shishvan OR, Zois D-S, Soyata T (2018) Machine intelligence in healthcare and medical cyber physical systems: A survey. IEEE Access 6:46419–46494

    Article  Google Scholar 

  27. Tyagi AK, Sreenath N (2021) Cyber Physical Systems: Analyses, challenges and possible solutions. Int Things Cyber-Physical Syst 1:22–33

    Article  Google Scholar 

  28. Tanwar S et al (2019) Machine learning adoption in blockchain-based smart applications: The challenges, and a way forward. IEEE Access 8:474–488

    Article  Google Scholar 

  29. Zhang Y et al (2015) Health-CPS: Healthcare cyber-physical system assisted by cloud and big data. IEEE Syst J 11(1):88–95

    Article  Google Scholar 

  30. Gupta BB et al (2021) Blockchain-assisted secure fine-grained searchable encryption for a cloud-based healthcare cyber-physical system. IEEE/CAA J Autom Sin 8(12):1877–1890

    Article  Google Scholar 

  31. Chen F et al (2021) Blockchain-based efficient device authentication protocol for medical cyber-physical systems. Security and Communication Networks. 2021.

  32. Chen F et al (2021) Data access control based on blockchain in medical cyber physical systems. Secur Commun Netw 2021

  33. Itoo S et al (2022) CKMIB: Construction of key agreement protocol for cloud medical infrastructure using blockchain. IEEE Access 10:67787–67801

    Article  Google Scholar 

  34. Cheng X et al (2019) Blockchain-based secure authentication scheme for medical data sharing. in International Conference of Pioneering Computer Scientists, Engineers and Educators. Springer.

  35. Sun J et al (2020) Blockchain-based secure storage and access scheme for electronic medical records in IPFS. IEEE Access 8:59389–59401

    Article  Google Scholar 

  36. Shu H et al (2020) An efficient certificateless aggregate signature scheme for blockchain-based medical cyber physical systems. Sensors 20(5):1521

    Article  Google Scholar 

  37. Ghayvat H et al (2021) CP-BDHCA: Blockchain-based Confidentiality-Privacy preserving Big Data scheme for healthcare clouds and applications. IEEE J Biomed Health Inform 26(5):1937–1948

    Article  Google Scholar 

  38. Wang Y et al (2019) Cloud-assisted EHR sharing with security and privacy preservation via consortium blockchain. Ieee Access 7:136704–136719

    Article  Google Scholar 

  39. Azbeg K, O Ouchetto, SJ Andaloussi (2022) BlockMedCare: A healthcare system based on IoT, Blockchain and IPFS for data management security. Egyptian Informatics Journal.

  40. Nguyen DC et al (2019) Blockchain for secure ehrs sharing of mobile cloud based e-health systems. IEEE access 7:66792–66806

    Article  Google Scholar 

  41. Akkaoui R, Hei X, Cheng W (2020) EdgeMediChain: a hybrid edge blockchain-based framework for health data exchange. IEEE access 8:113467–113486

    Article  Google Scholar 

  42. Lakhan A et al (2022) Blockchain-Enabled Cybersecurity Efficient IIOHT Cyber-Physical System for Medical Applications. IEEE Transactions on Network Science and Engineering

  43. Rahmadika S et al (2022) Blockchain-based privacy preservation scheme for misbehavior detection in lightweight IoMT devices. IEEE Journal of Biomedical and Health Informatics.

  44. Jain S et al (2020) Blockchain and Machine Learning in Health Care and Management. in 2020 International Conference on Mainstreaming Block Chain Implementation (ICOMBI). IEEE.

  45. Lakhan A et al (2023) DRLBTS: deep reinforcement learning-aware blockchain-based healthcare system. Sci Rep 13(1):4124

    Article  Google Scholar 

  46. Rahman MA et al (2020) Secure and provenance enhanced internet of health things framework: A blockchain managed federated learning approach. Ieee Access 8:205071–205087

    Article  Google Scholar 

  47. Haque RU et al (2020) Privacy-preserving K-nearest neighbors training over blockchain-based encrypted health data. Electronics 9(12):2096

    Article  Google Scholar 

  48. Ch R et al (2022) Robust Cyber-Physical System Enabled Smart Healthcare Unit Using Blockchain Technology. Electronics 11(19):3070

    Article  Google Scholar 

  49. Panwar A et al (2022) A Blockchain Framework to Secure Personal Health Record (PHR) in IBM Cloud-Based Data Lake. Computational Intelligence and Neuroscience, 2022.

  50. Akhter Md Hasib KT et al (2022) Electronic health record monitoring system and data security using blockchain technology. Secur Commun Networks 2022:1–15

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hind A. Al-Ghuraybi.

Ethics declarations

Conflicts of interest

Competing interests There is no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Al-Ghuraybi, H.A., AlZain, M.A. & Soh, B. Ensuring authentication in Medical Cyber-Physical Systems: A comprehensive literature review of blockchain technology integration with machine learning. Multimed Tools Appl 83, 35673–35707 (2024). https://doi.org/10.1007/s11042-023-17065-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11042-023-17065-3

Keywords

Navigation