Abstract
Knee osteoarthritis (OA) is a disease of the joints and a leading cause of disability among the elderly. If detected at an early stage, its advancement can be slowed and the patient’s suffering can be reduced. A new approach involving multiscale convolutional blocks in convolutional neural network (MCBCNN) has been introduced in this paper for automatic classification and grading of knee OA. The proposed model is implemented using pretrained convolutional neural networks (CNNs) and multiscale convolutional filters. Three pretrained CNN models, namely mobileNet2, resNet50 and inceptionNetv3 have been used for the implementation of MCBCNN. Exhaustive performance analysis has been conducted on the three proposed models. The results of knee OA grading delivered by all the three proposed MCBCNNs have been compared. The results show that the performance of MCBCNNs is better than that of the pretrained CNNs. Among the proposed three MCBCNNs, the MCB resNet50 delivers better performance in terms of average accuracy of over \(95\%\), area under curve of nearly 0.9 and F1 score of 0.8.
Similar content being viewed by others
References
Abedin J et al (2019) Predicting knee osteoarthritis severity: comparative modeling based on patient’s data and plain x-ray images. Sci Rep 9(1):5761
Anthimopoulos M et al (2016) Lung pattern classification for interstitial lung diseases using a deep convolutional neural network. IEEE Trans Med Imag 35(5):1207–1216
Antony J et al. (2016) Quantifying radiographic knee osteoarthritis severity using deep convolutional neural networks. In: Proceedings of the 23rd international conference on pattern recognition (ICPR), IEEE pp. 1195–1200
Bellamy N et al (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15(12):1833–1840
Bengio Y (2012) Deep learning of representations for unsupervised and transfer learning. In: I. Guyon, G. Dror, V. Lemaire, G.W. Taylor, D.L. Silver (eds.) Unsupervised and transfer learning - Workshop held at ICML 2011, Bellevue, Washington, USA, July 2, 2011, JMLR Proceedings, vol. 27, pp. 17–36. JMLR.org
Chaterjee M (2020) Top 20 applications of deep learning in 2020 across industries. https://www.mygreatlearning.com/blog/top-15-applications-of-deep-learning/
Chen P, Gao L, Shi X, Allen K, Yang L (2019) Fully automatic knee osteoarthritis severity grading using deep neural networks with a novel ordinal loss. Comput Med Imag Graph 75:84–92
Du Y et al (2018) A novel method to predict knee osteoarthritis progression on MRI using machine learning methods. IEEE Trans Nanobiosci 17(3):228–236
Emad O, Yassine IA, Fahmy AS (2015) Automatic localization of the left ventricle in cardiac MRI images using deep learning. In: Proceedings of the 37th IEEE annual international conference on engineering in medicine and biology society (EMBC), pp. 683–686
Fei-Fei L, Deng J, Li K (2009) ImageNet: constructing a large-scale image database. J Vis 9(8):1037
Gao XW, Hui R (2016) A deep learning based approach to classification of CT brain images. In: Proceedings of the SAI computing conference, pp. 28–31
van Grinsven MJ et al (2016) Fast convolutional neural network training using selective data sampling: application to hemorrhage detection in color fundus images. IEEE Trans Med Imag 35(5):1273–1284
Havaei M et al (2017) Brain tumor segmentation with deep neural networks. Med Imag Anal 35:18–31
He K, et al. (2016) Deep residual learning for image recognition. In: Proceedings of the IEEE conference on computer vision and pattern recognition, (CVPR), pp. 770–778
K, A.J.M., K, M., N.E, O (2017) Automatic detection of knee joints and quantification of knee osteoarthritis severity using convolutional neural networks. In: Machine learning and data mining in pattern recognition. Lecture notes in computer science, Springer, vol. 10358. https://doi.org/10.1007/978-3-319-62416-7_27
Kashyap S et al (2018) Learning-based cost functions for 3-D and 4-D multi-surface multi-object segmentation of knee MRI: ddata from the osteoarthritis initiative. IEEE Trans Med Imag 37(5):1103–1113
Kohn MD, Sassoon AA, Fernando ND (2016) Classifications in brief: Kellgren-lawrence classification of osteoarthritis. Clin Orthop Relat Res 474:1886–1893. https://doi.org/10.1007/s11999-016-4732-4
Krizhevsky A, Sutskever I, Hinton GE (2012) Imagenet classification with deep convolutional neural networks. In: Proceedings of the 26th Annual conference on neural information processing systems, pp. 1106–1114
LeCun Y et al (1998) Gradient-based learning applied to document recognition. Proc IEEE 86(11):2278–2324
(OAI), T.O.I (2020) Data from the osteoarthritis initiative. https://nda.nih.gov/oai//
Oka H et al (2008) Fully automatic quantification of knee osteoarthritis severity on plain radiographs. Osteoarthr Cartil 16(11):1300–1306
Orlov N, Shamir L, Macura TJ, Johnston J, Eckley DM, Goldberg IG (2008) WND-CHARM: multi-purpose image classification using compound image transforms. Pattern Recognit Lett 29(11):1684–1693. https://doi.org/10.1016/j.patrec.2008.04.013
Pal CP et al (2016) Epidemiology of knee osteoarthritis in India and related factors. Indian J Orthop 50(5):518
Panfilov E, et al.: Improving robustness of deep learning based knee MRI segmentation: Mixup and adversarial domain adaptation. CoRR abs/1908.04126 (2019)
Pratt H, et al. (2016) Convolutional neural networks for diabetic retinopathy. In: Proceedings of the 20th conference on medical image understanding and analysis, MIUA, pp. 200–205
Russakovsky O, Deng J, Su H, Krause J, Satheesh S, Ma S, Huan Z, Karpathy A, Khosla A, Bernstein M, Berg AC, Fei-Fei L (2015) ImageNet large scale visual recognition challenge. Int J Comput Vis (IJCV) 115(3):211–252. https://doi.org/10.1007/s11263-015-0816-y
Sajjad M et al (2019) Multi-grade brain tumor classification using deep CNN with extensive data augmentation. J Comput Sci 30:174–182
Sarvamangala D, Kulkarni RV (2021) Convolutional neural networks in medical image understanding: a survey. Evolutionary Intelligence pp. 1–22
Simonyan K, Zisserman A (2014) Very deep convolutional networks for large-scale image recognition. Computer Research Repository abs/1409.1556
Sirinukunwattana K et al (2016) Locality sensitive deep learning for detection and classification of nuclei in routine colon cancer histology images. IEEE Trans Med Imag 35(5):1196–1206
Subramoniam Barani (2015) Rajini: a non-invasive computer aided diagnosis of osteoarthritis from digital x-ray images. Biomed Res 26:721–729
Subramoniam M, Rajini V (2013) Local binary pattern approach to the classification of osteoarthritis in knee x-ray images. Asian J Sci Res 6(4):805–811
Sun W et al (2017) Enhancing deep convolutional neural network scheme for breast cancer diagnosis with unlabeled data. Comput Med Imag Graph 57:4–9
Szegedy C, et al. (2015) Going deeper with convolutions. In: Proceedings of the IEEE conference on computer vision and pattern recognition (CVPR), pp. 1–9
Tajbakhsh N et al (2016) Convolutional neural networks for medical image analysis: Full training or fine tuning? IEEE Trans Med Imag 35(5):1299–1312
Tiulpin A et al (2018) Automatic knee osteoarthritis diagnosis from plain radiographs: a deep learning-based approach. Sci Rep 8(1):17–27
Torre L, Shavli JW, Walker T, Maclin R (2010) Transfer learning via advice taking. In: J. Koronacki, Z.W. Ras, S.T. Wierzchon, J. Kacprzyk (eds.) Advances in machine learning I: dedicated to the memory of Professor Ryszard S. Michalski, Studies in Computational Intelligence, vol. 262, pp. 147–170. Springer
Wang D, et al. (2016) Deep learning for identifying metastatic breast cancer. Computer Research Repository abs/1606.05718
Zhao L, Ji K (2015) Deep feature learning with discrimination mechanism for brain tumor segmentation and diagnosis. In: Proceedings of the international conference onintelligent information hiding and multimedia signal processing (IIH-MSP), pp. 306–309. IEEE
Acknowledgements
Authors acknowledge with gratitude the support received from REVA University, Bengaluru, and M S Ramaiah University of Applied Sciences, Bengaluru. Authors also thank profusely the anonymous reviewers of this paper for their constructive criticism.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sarvamangala, D.R., Kulkarni, R.V. Grading of Knee Osteoarthritis Using Convolutional Neural Networks. Neural Process Lett 53, 2985–3009 (2021). https://doi.org/10.1007/s11063-021-10529-3
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11063-021-10529-3