Skip to main content
Log in

On the relative efficiency of a monotone parameter curve estimator in a functional nonlinear model

  • Published:
Statistics and Computing Aims and scope Submit manuscript

Abstract

Functional regression models that relate functional covariates to a scalar response are becoming more common due to the availability of functional data and computational advances. We introduce a functional nonlinear model with a scalar response where the true parameter curve is monotone. Using the Newton-Raphson method within a backfitting procedure, we discuss a penalized least squares criterion for fitting the functional nonlinear model with the smoothing parameter selected using generalized cross validation. Connections between a nonlinear mixed effects model and our functional nonlinear model are discussed, thereby providing an additional model fitting procedure using restricted maximum likelihood for smoothing parameter selection. Simulated relative efficiency gains provided by a monotone parameter curve estimator relative to an unconstrained parameter curve estimator are presented. In addition, we provide an application of our model with data from ozonesonde measurements of stratospheric ozone in which the measurements are biased as a function of altitude.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Bates, M.B., Watts, D.G.: Nonlinear Regression Analysis, 1st edn. Wiley, New York (1988)

    Book  MATH  Google Scholar 

  • Bigot, M., Gadat, S.: Smoothing under diffeomorphic constraints with homeomorphic splines. SIAM J. Numer. Anal. 48(1), 224–243 (2010)

    Article  MathSciNet  MATH  Google Scholar 

  • Cardot, H., Ferraty, F., Sarda, P.: Spline estimators for the functional linear model. Stat. Sin. 13, 571–591 (2003)

    MathSciNet  MATH  Google Scholar 

  • Craven, P., Wahba, W.: Smoothing noisy data with spline functions: estimating the correct degree of smoothing by the method of generalized cross-validation. Numer. Math. 31(4), 377–403 (1979)

    Article  MathSciNet  MATH  Google Scholar 

  • Efron, B., Tibshirani, R.J.: An Introduction to the Bootstrap, 1st edn. Chapman and Hall, London (1993)

    MATH  Google Scholar 

  • Eubank, R.: Nonparametric Regression and Spline Smoothing, 2nd edn. Dekker, New York (1999)

    MATH  Google Scholar 

  • Eubank, R.L., Kong, M.: Monotone smoothing with application to dose-response curve. Stat. Probab. Lett. 35(4), 991–1004 (2006)

    MathSciNet  MATH  Google Scholar 

  • Ferraty, F., Vieu, P.: Nonparametric Functional Data Analysis: Theory and Practice, 1st edn. Springer, Berlin (2006)

    MATH  Google Scholar 

  • Friedman, J., Tibshirani, R.J.: The monotone smoothing of scatterplots. Technometrics 26(3), 242–250 (1984)

    Article  Google Scholar 

  • Harville, D.: Maximum likelihood approaches to variance component estimation and to related problems. J. Am. Stat. Assoc. 72(358), 320–338 (1977)

    Article  MathSciNet  MATH  Google Scholar 

  • Hyman, J.M.: Accurate monotonicity preserving cubic interpolation. SIAM J. Sci. Stat. Comput. 4(4), 645–654 (1983)

    Article  MathSciNet  MATH  Google Scholar 

  • Kelly, C., Rice, J.: Monotone smoothing with application to dose-response curves and the assessment of synergism. Biometrics 46(4), 1071–1085 (1990)

    Article  Google Scholar 

  • Lindstrom, M.J., Bates, D.M.: Nonlinear mixed effects models for repeated measures data. Biometrics 46(3):673–687 (1990)

    Article  MathSciNet  Google Scholar 

  • Logan, J.A., Megretskaia, I.A., Miller, A.J., Choi, D., Zhang, L., Stolarski, R.S., Labow, G.J., Hollandsworth, S.M., Bodeker, G.E., Claude, H., De Muer, D., Kerr, J.B., Tarasick, D.W., Oltmans, S.J., Johnson, B., Schmidlin, F., Staehelin, J., Viatte, P., Uchino, O.: Trends in the vertical distribution of ozone: a comparison of two analyses of ozonesonde data. J. Geophys. Res. 104(26), 373–399 (1999)

    Google Scholar 

  • Mammen, E.: Estimating a smooth monotone regression function. Ann. Stat. 19(2), 724–740 (1991)

    Article  MathSciNet  MATH  Google Scholar 

  • Mammen, E., Thomas-Agnan, C.: Smoothing splines and shape restrictions. Scand. J. Stat. 26, 239–252 (1999)

    Article  MathSciNet  MATH  Google Scholar 

  • Mammen, E., Marron, J.S., Turlach, B.A., Wand, M.P.: A general projection framework for constrained smoothing. Stat. Sci. 16(3), 232–248 (2001)

    Article  MathSciNet  MATH  Google Scholar 

  • Meiring, W.: Oscillations and time trends in stratospheric ozone levels: a functional data analysis approach. J. Am. Stat. Assoc. 102(479), 788–802 (2007)

    Article  MathSciNet  MATH  Google Scholar 

  • Montoya, EL: Constrained functional data models with environmental applications. PhD dissertation, University of California, Santa Barbara (2009)

  • Pinheiro, J.C., Bates, D.M.: Mixed Effects Models in S and S-Plus, 1st edn. Springer, Berlin (2002)

    Google Scholar 

  • Pinheiro, J., Bates, D., DebRoy, S., Sarkar, D., the R Core team: nlme: linear and nonlinear mixed effects models. R package version 3.1-91 (2009)

  • R Development Core Team: R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna (2009). ISBN 3-900051-07-0

    Google Scholar 

  • Ramsay, J.O.: Monotone regression splines in action. Stat. Sci. 3(4), 425–441 (1988)

    Article  Google Scholar 

  • Ramsay, J.O.: Estimating smooth monotone functions. J. R. Stat. Soc. B 60(2), 365–375 (1998)

    Article  MathSciNet  MATH  Google Scholar 

  • Ramsay, J.O., Silverman, B.W.: Applied Functional Data Analysis, 1st edn. Springer, Berlin (2002)

    MATH  Google Scholar 

  • Ramsay, J.O., Silverman, B.W.: Functional Data Analysis, 2nd edn. Springer, Berlin (2005)

    Google Scholar 

  • Ramsay, J.O., Wickham, H., Graves, S., Hooker, G.: fda: functional data analysis. R package version 2.1.1 (2008)

  • Robertson, T., Wright, F.T., Dykstra, R.L.: Order Restricted Statistical Inference, 1st edn. Wiley, New York (1988)

    MATH  Google Scholar 

  • Schipper, M., Taylor, J.M.G., Lin, X.: Bayesian generalized monotonic functional mixed models for the effects of radiation dose histograms on normal tissue complications. Stat. Med. 26(25), 4643–4656 (2007)

    Article  MathSciNet  Google Scholar 

  • Schipper, M., Taylor, J.M.G., Lin, X.: Generalized monotonic functional mixed models with application to modelling normal tissue complications. J. R. Stat. Soc., Ser. C 57(2), 149–163 (2008)

    Article  MathSciNet  MATH  Google Scholar 

  • Seber, G.A.F., Wild, C.J.: Nonlinear Regression, 1st edn. Wiley, New York (1989)

    Book  MATH  Google Scholar 

  • SPARC Assessment of trends in the vertical distribution of ozone. Project report 43, World Meteorological Organization Global Ozone Research and Monitoring Project (WCRP-SPARC Report 1) (1998)

  • Steinbrecht, W., Schwarz, R., Claude, H.: New pump correction for the brewer-mast ozone sonde: determination from experiment and instrument intercomparisons. J. Atmos. Ocean. Technol. 15(1), 144–156 (1998)

    Article  Google Scholar 

  • Turner, R.: Iso: functions to perform isotonic regression. R package version 0.0-8 (2009)

  • Wahba, G.: Spline Models for Observed Data, 1st edn. Society for Industrial and Applied Mathematics, Philadelphia (1990)

    Book  Google Scholar 

  • Wand, M.P., Ormerod, J.T.: On semiparametric regression with O’Sullivan penalised splines. Aust. N. Z. J. Stat. 50(2), 179–198 (2008)

    Article  MathSciNet  MATH  Google Scholar 

  • Wood, S.: Monotonic smoothing splines fitted by cross validation. SIAM J. Sci. Comput. 15(5), 1126–1133 (1994)

    Article  MathSciNet  MATH  Google Scholar 

  • Zhang, J.: A simple and efficient monotone smoother using smoothing splines. J. Nonparametr. Stat. 16(5), 779–796 (2004)

    Article  MathSciNet  MATH  Google Scholar 

Download references

Acknowledgements

We would like to thank the Editor, Associate Editor and two referees for their valuable comments and suggestions that significantly improved the paper. In particular, the comments from one referee led to the simulation based comparison with the smooth-then-monotonize PAV approach extended to the FLM, and expanded literature review. The first author’s research was partially supported by a Graduate Student Central Fellowship from University of California, Santa Barbara.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eduardo L. Montoya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Montoya, E.L., Meiring, W. On the relative efficiency of a monotone parameter curve estimator in a functional nonlinear model. Stat Comput 23, 425–436 (2013). https://doi.org/10.1007/s11222-012-9320-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11222-012-9320-1

Keywords

Navigation