Skip to main content
Log in

Deep learning-based hysteroscopic intelligent examination and ultrasound examination for diagnosis of endometrial carcinoma

  • Published:
The Journal of Supercomputing Aims and scope Submit manuscript

Abstract

The study aimed to explore the performance of deep learning-based hysteroscopy intelligent examination combined with ultrasound examination in the diagnosis of endometrial carcinoma (EC). Specifically, 80 EC patients, diagnosed by hysteroscopic cervical tissue biopsy were selected as the research subjects, and they were divided into the experimental group, and the control group. The Dense-Pyramid-Attention U-Net (DPA-UNet) algorithm image processing method based on deep learning was applied to diagnose patients in the experimental group. Then, different diagnosis methods were compared for the accuracy rates of the preoperative staging and the diagnosis results. The results showed that compared with U-Net and Dense-Net models, the image clarity processed by the DPA-UNet model was improved and the lesion site was clearer, and its Dice similarity coefficient (DSC), precision, and recall were 80.4 ± 18%, 80.1 ± 15%, 87.6 ± 11%, respectively, higher than those of U-Net and Dense-Net model, and the difference wax statistically significant (P < 0.05); the diagnosis result coincidence rate of the experimental group was 91.8%, significantly better than that of the control group 64.1%, and the difference was statistically significant. In conclusion, the deep learning-based hysteroscope intelligent inspection system combined with ultrasound images may provide an efficient way for early diagnosis of EC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13

Similar content being viewed by others

References

  1. Gentry-Maharaj A, Karpinskyj C (2020) Current and future approaches to screening for endometrial cancer. Best Pract Res Clin Obstet Gynaecol 65:79–97. https://doi.org/10.1016/j.bpobgyn.2019.12.006

    Article  Google Scholar 

  2. Clarke MA, Long BJ, Sherman ME, Lemens MA, Podratz KC, Hopkins MR, Ahlberg LJ, Mc Guire LJ, Laughlin-Tommaso SK, Bakkum-Gamez JN, Wentzensen N (2020) Risk assessment of endometrial cancer and endometrial intraepithelial neoplasia in women with abnormal bleeding and implications for clinical management algorithms. Am J Obstet Gynecol 223(4):549.e1-549.e13. https://doi.org/10.1016/j.ajog.2020.03.032

    Article  Google Scholar 

  3. Míka O, Kožnarová J, Sak P (2017) Ultrazvukový staging časných stadií karcinomu endometria, analýza vlastního souboru za období let 2012–2016 [Ultrasound staging of stage I-II endometrial cancer, analysis of own file in the years 2012–2016]. Ceska Gynekol 82(3):218–226

    Google Scholar 

  4. Long B, Clarke MA, Morillo ADM, Wentzensen N, Bakkum-Gamez JN (2020) Ultrasound detection of endometrial cancer in women with postmenopausal bleeding: systematic review and meta-analysis. Gynecol Oncol 157(3):624–633. https://doi.org/10.1016/j.ygyno.2020.01.032

    Article  Google Scholar 

  5. Burai P, Hajdu A, Manuel FE, Harangi B (2018) Segmentation of the uterine wall by an ensemble of fully convolutional neural networks. Annu Int Conf IEEE Eng Med Biol Soc 2018:49–52. https://doi.org/10.1109/EMBC.2018.8512245

    Article  Google Scholar 

  6. Braun MM, Overbeek-Wager EA, Grumbo RJ (2016) Diagnosis and management of endometrial cancer. Am Fam Physician 93(6):468–474

    Google Scholar 

  7. Faria SC, Devine CE, Rao B, Sagebiel T, Bhosale P (2019) Imaging and staging of endometrial cancer. Semin Ultrasound CT MR 40(4):287–294. https://doi.org/10.1053/j.sult.2019.04.001

    Article  Google Scholar 

  8. Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Frühauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch T (2018) Ultrasound characteristics of endometrial cancer as defined by international endometrial tumor analysis (IETA) consensus nomenclature: prospective multicenter study. Ultrasound Obstet Gynecol 51(6):818–828. https://doi.org/10.1002/uog.18909 (Erratum In: Ultrasound Obstet Gynecol. 2018 Nov; 52(5): 684)

    Article  Google Scholar 

  9. Capozzi VA, Rosati A, Rumolo V, Ferrari F, Gullo G, Karaman E, Karaaslan O, HacioĞlu L (2021) Novelties of ultrasound imaging for endometrial cancer preoperative workup. Minerva Med 112(1):3–11. https://doi.org/10.23736/S0026-4806.20.07125-6

    Article  Google Scholar 

  10. Chen Y, Hu S, Mao H, Deng W, Gao X (2020) Application of the best evacuation model of deep learning in the design of public structures. Image Vis Computing. https://doi.org/10.1016/j.imavis.2020.103975

    Article  Google Scholar 

  11. Rizzo S, Femia M, Buscarino V, Franchi D, Garbi A, Zanagnolo V, Del Grande M, Manganaro L, Alessi S, Giannitto C, Ruju F, Bellomi M (2018) Endometrial cancer: an overview of novelties in treatment and related imaging keypoints for local staging. Cancer Imaging 18(1):45. https://doi.org/10.1186/s40644-018-0180-6

    Article  Google Scholar 

  12. Bodurtha Smith AJ, Fader AN, Tanner EJ (2017) Sentinel lymph node assessment in endometrial cancer: a systematic review and meta-analysis. Am J Obstet Gynecol 216(5):459-476.e10. https://doi.org/10.1016/j.ajog.2016.11.1033

    Article  Google Scholar 

  13. Vetter MH, Smith B, Benedict J, Hade EM, Bixel K, Copeland LJ, Cohn DE, Fowler JM, O’Malley D, Salani R, Backes FJ (2020) Preoperative predictors of endometrial cancer at time of hysterectomy for endometrial intraepithelial neoplasia or complex atypical hyperplasia. Am J Obstet Gynecol 222(1):60.e1-60.e7. https://doi.org/10.1016/j.ajog.2019.08.002

    Article  Google Scholar 

  14. Green RW, Valentin L, Alcazar JL, Chiappa V, Erdodi B, Franchi D, Frühauf F, Fruscio R, Guerriero S, Graupera B, Jakab A, di Legge A, Ludovisi M, Mascilini F, Pascual MA, van den Bosch T, Epstein E (2018) Endometrial cancer off-line staging using two-dimensional transvaginal ultrasound and three-dimensional volume contrast imaging: intermethod agreement, interrater reliability and diagnostic accuracy. Gynecol Oncol 150(3):438–445. https://doi.org/10.1016/j.ygyno.2018.06.027

    Article  Google Scholar 

  15. Alcázar JL, Gastón B, Navarro B, Salas R, Aranda J, Guerriero S (2017) Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with endometrial cancer: a systematic review and meta-analysis. J Gynecol Oncol 28(6):e86. https://doi.org/10.3802/jgo.2017.28.e86

    Article  Google Scholar 

  16. Lv Z, Xiu W (2020) Interaction of edge-cloud computing based on SDN and NFV for next generation IoT. IEEE Internet Things J 7(7):5706–5712. https://doi.org/10.1109/JIOT.2019.2942719

    Article  Google Scholar 

  17. Singh SP, Wang L, Gupta S, Goli H, Padmanabhan P, Gulyás B (2020) 3D deep learning on medical images: a review. Sensors (Basel) 20(18):5097. https://doi.org/10.3390/s20185097

    Article  Google Scholar 

  18. Currie G, Hawk KE, Rohren E, Vial A, Klein R (2019) Machine learning and deep learning in medical imaging: intelligent imaging. J Med Imaging Radiat Sci 50(4):477–487. https://doi.org/10.1016/j.jmir.2019.09.005

    Article  Google Scholar 

  19. Gao X, Cai J (2017) Optimization analysis of urban function regional planning based on big data and gis technology. Bol Tecnico/Tech Bull 55(11):344–351

    Google Scholar 

  20. Wang S, Yang DM, Rong R, Zhan X, Xiao G (2019) Pathology image analysis using segmentation deep learning algorithms. Am J Pathol 189(9):1686–1698. https://doi.org/10.1016/j.ajpath.2019.05.007

    Article  Google Scholar 

  21. Fu Y, Lei Y, Wang T, Curran WJ, Liu T, Yang X (2020) Deep learning in medical image registration: a review. Phys Med Biol 65(20):20TR01. https://doi.org/10.1088/1361-6560/ab843e

    Article  Google Scholar 

  22. Anwar SM, Majid M, Qayyum A, Awais M, Alnowami M, Khan MK (2018) Medical image analysis using convolutional neural networks: a review. J Med Syst 42(11):226. https://doi.org/10.1007/s10916-018-1088-1

    Article  Google Scholar 

  23. Török P, Harangi B (2018) Digital image analysis with fully connected convolutional neural network to facilitate hysteroscopic fibroid resection. Gynecol Obstet Invest 83(6):615–619. https://doi.org/10.1159/000490563

    Article  Google Scholar 

  24. Zhang Y, Wang Z, Zhang J, Wang C, Wang Y, Chen H, Shan L, Huo J, Gu J, Ma X (2021) Deep learning model for classifying endometrial lesions. J Transl Med 19(1):10. https://doi.org/10.1186/s12967-020-02660-x

    Article  Google Scholar 

  25. Takahashi Y, Sone K, Noda K, Yoshida K, Toyhara Y, Kato K, Inoue F, Kukita A, Taguchi A, Nishida H, Miyamoto Y, Tanikawa M, Tsuruga T, Iriyama T, Nagasaka K, Matsumoto Y, Hirota Y, Hiraike-Wada O, Oda K, Maruyama M, Osuga Y, Fujii T (2021) Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy. PLoS ONE 16(3):e0248526. https://doi.org/10.1371/journal.pone.0248526

    Article  Google Scholar 

  26. Falk T, Mai D, Bensch R, Çiçek Ö, Abdulkadir A, Marrakchi Y, Böhm A, Deubner J, Jäckel Z, Seiwald K, Dovzhenko A, Tietz O, Dal Bosco C, Walsh S, Saltukoglu D, Tay TL, Prinz M, Palme K, Simons M, Diester I, Brox T, Ronneberger O (2019) U-Net: deep learning for cell counting, detection, and morphometry. Nat Methods 16(1):67–70. https://doi.org/10.1038/s41592-018-0261-2 (Erratum In: Nat Methods. 2019 Apr; 16(4): 351)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jihong Tu.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xia, Z., Zhang, L., Liu, S. et al. Deep learning-based hysteroscopic intelligent examination and ultrasound examination for diagnosis of endometrial carcinoma. J Supercomput 78, 11229–11244 (2022). https://doi.org/10.1007/s11227-021-04046-2

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11227-021-04046-2

Keywords

Navigation