Abstract
This paper considers a widely used mixed effects model in repeated measures under heteroscedasticity. Hypotheses of the equality of the fixed effects and the simultaneous confidence intervals for all pair-wise differences are discussed. A generalized F-test has been proposed to test the equality of the fixed effects in the model, but simulation results for evaluating its performance have not been shown in the literature. Moreover, the generalized F-test cannot be used to deduce the simultaneous confidence intervals for all pair-wise differences of the fixed effects. The authors propose two new p-values to test the hypotheses of equality of the fixed effects and simultaneous confidence intervals of the differences of the effects based on the generalized pivotal quantities derived in this paper. The authors also compare the empirical performances of the proposed tests and the generalized F-test. The type I error rates and powers of these tests are evaluated using the Monte Carlo simulation. The simulation studies show that the generalized F-test does not perform well in terms of type I error rate under various sample size and parameter combinations. However, the type I error probabilities of the proposed tests are always close to the nominal value. It can also be seen that the simultaneous confidence intervals perform well.
Similar content being viewed by others
References
S. Weerahandi, Exact Statistical Methods for Data Analysis, Springer-Verlag, New York, 1995.
K. W. Tisu and S. Weerahandi, Generalized p-values in significance testing of hypotheses in the presence of nuisance parameters, Journal of the American Statistical Association, 1989, 84: 602–607.
S. Weerahandi, Generalized confidence intervals, Journal of the American Statistical Association, 1993, 88: 899–905.
J. Hannig, H. Iyer, and P. Patterson, Fiducial generalized confidence intervals, Journal of the American Statistical Association, 2006, 101: 254–269.
S. Weerahandi, ANOVA under unequal error variances, Biometrics, 1995, 51: 589–599.
M. M. A. Ananda and S. Weerahandi, Two-way ANOVA with unequal cell frequencies and unequal variances, Statistica Sinica, 1997, 7: 631–646.
J. Gamage and S. Weerahandi, Size performance of some tests in one-way ANOVA, Communication in Statistics-Simulation and Computation, 1998, 27: 625–640.
P. Bao and M. M. A. Ananda, Performance of two-way ANOVA procedures when cell frequencies and variances are unequal, Communication in Statistics-Simulation and Computation, 2001, 30: 805–829.
S. Weerahandi, Generalized Inference in Repeated Measures, Springer-Verlag, New York, 2004.
B. D. Burch, Generalized confidence intervals for proportions of total variance in mixed linear models, Journal of Statistical of Planning and Inference, 2007, 137: 2394–2404.
W. Mu, S. Xiong, and X. Xu, Generalized confidence regions of fixed effects in the two-way ANOVA, Journal of Systems Science and Complexity, 2008, 21(2): 276–282.
S. Xiong, W. Mu, and X. Xu, Generalized inference for a class of linear models under heteroscedasticity, Communication in Statistics — Theory and Method, 2008, 37: 1225–1236.
E. M. Chi and S. Weerahandi, Comparing treatments under growth curve models: Exact tests using generalized p-values, Journal of Statistical of Planning and Inference, 1998, 71: 179–189.
S. Weerahandi and V. W. Berger, Exact inference for growth curves with intraclass correlation structure, Biometrics, 1999, 55: 921–924.
S. H. Lin and J. C. Lee, Exact tests in simple growth curve models and one-way ANOVA with equicorrelation error structure, Journal of Multivariate Analysis, 2003, 84: 351–368.
Y. Y. Ho and S. Weerahandi, Analysis of repeated measures under unequal variances, Journal of Multivariate Analysis, 2007, 98: 493–504.
K. Krishnamoorthy, F. Lu, and T. Mathew, A parametric bootstrap approach for ANOVA with unequal variances: Fixed and random models, Computational Statistics and Data Analysis, 2007, 51: 5731–5742.
X. Li and G. Li, Confidence intervals on sum of variance components with unbalanced designs, Communication in Statistics — Theory and Method, 2005, 34: 833–845.
L. Tian, C. Ma, and A. Vexler, A parametric bootstrap approach for testing equality of inverse Gaussian means under heterogeneity, Communication in Statistics-Simulation and Computation, 2009, 38: 1026–1036.
X. Li, J. Wang, and H. Liang, Comparison of several means: A fiducial based approach, Computational Statistics and Data Analysis, 2011, 55: 1993–2002.
S. Xiong, An asymptotics look at the generalized inference, Journal of Multivariate Analysis, 2011, 102: 336–348.
S. Xiong and W. Mu, Simultaneous confidence intervals for one-way layout based on generalized pivotal quantities, Journal of Statistical Computation and Simulation, 2009, 79: 1235–1244.
Author information
Authors and Affiliations
Corresponding author
Additional information
This research was supported by the National Natural Science Foundation of China under Grant Nos. 11126243 and 11071015, Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality (PHR 201107123), and School Scientific Found under Grant No. 101002207.
This paper was recommended for publication by Editor Guohua ZOU.
Rights and permissions
About this article
Cite this article
Mu, W., Xu, X. Inference for repeated measures models under heteroscedasticity. J Syst Sci Complex 25, 1158–1170 (2012). https://doi.org/10.1007/s11424-012-0170-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11424-012-0170-x