Abstract
Autoimmune diseases are generated through irregular immune response of the human body. Psoriasis is one type of autoimmune chronic skin diseases that is differentiated by T-Cells mediated hyper-proliferation of epidermal Keratinocytes. Dendritic Cells and CD8+ T-Cells have a significant role for the occurrence of this disease. In this paper, the authors have developed a mathematical model of Psoriasis involving CD4+ T-Cells, Dendritic Cells, CD8+ T-Cells and Keratinocyte cell populations using the fractional differential equations with the effect of Cytokine release to observe the impact of memory on the cell-biological system. Using fractional calculus, the authors try to explore the suppressed memory, associated with the cell-biological system and to locate the position of Keratinocyte cell population as fractional derivative possess non-local property. Thus, the dynamics of Psoriasis can be predicted in a better way using fractional differential equations rather than its corresponding integer order model. Finally, the authors introduce drug into the system to obstruct the interaction between CD4+ T-Cells and Keratinocytes to restrict the disease Psoriasis. The authors derive the Euler-Lagrange conditions for the optimality of the drug induced system. Numerical simulations are made through Matlab by developing iterative schemes.
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This research is supported by the Council of Scientific and Industrial Research, Government of India under Grant No. 38 (1320)/12/EMR-II.
This paper was recommended for publication by Editor SUN Jian.
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Cao, X., Datta, A., Al Basir, F. et al. Fractional-order model of the disease Psoriasis: A control based mathematical approach. J Syst Sci Complex 29, 1565–1584 (2016). https://doi.org/10.1007/s11424-016-5198-x
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DOI: https://doi.org/10.1007/s11424-016-5198-x