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Non-invasive continuous estimation of blood flow changes in human patellar bone

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Abstract

A photoplethysmographic (PPG) technique to assess blood flow in bone tissue has been developed and tested. The signal detected by the PPG consists of a constant-level (DC) component—which is related to the relative vascularization of the tissue—and a pulsatile (AC) component—which is synchronous with the pumping action of the heart. The PPG probe was applied on the skin over the patella. The probe uses near-infrared (804 nm) and green (560 nm) light sources and the AC component of the PPG signals of the two wavelengths was used to monitor pulsatile blood flow in the patellar bone and the overlying skin, respectively. Twenty healthy subjects were studied and arterial occlusion resulted in elimination of PPG signals at both wavelengths, whereas occlusion of skin blood flow by local surface pressure eliminated only the PPG signal at 560 nm. In a parallel study on a physical model with a rigid tube we showed that the AC component of the PPG signal originates from pulsations of blood flow in a rigid structure and not necessarily from volume pulsations. We conclude that pulsatile blood flow in the patellar bone can be assessed with the present PPG technique.

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Acknowledgments

The authors wish to thank Per Sveider and Bengt Ragnemalm for technical assistance, Iréne Lund for statistical advice, and Erik Lundeberg for preparing some of the illustrations.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden

    Jan Näslund & Dag Linnarsson

  2. Department of Biomedical Engineering, Linköping University, Linkoping, Sweden

    Jonas Pettersson & Lars-Göran Lindberg

  3. Rehabilitation Medicine University Clinic Stockholm, Danderyds Hospital, Stockholm, Sweden

    Thomas Lundeberg

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  1. Jan Näslund
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  2. Jonas Pettersson
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Correspondence to Jan Näslund.

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Näslund, J., Pettersson, J., Lundeberg, T. et al. Non-invasive continuous estimation of blood flow changes in human patellar bone. Med Bio Eng Comput 44, 501–509 (2006). https://doi.org/10.1007/s11517-006-0070-0

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  • DOI: https://doi.org/10.1007/s11517-006-0070-0

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