Skip to main content

Advertisement

Springer Nature Link
Log in

Proof of concept percutaneous treatment system to enable fast and finely controlled ablation of biological tissue

  • Original Article
  • Published:
Medical & Biological Engineering & Computing Aims and scope Submit manuscript

Abstract

A prototype system has been developed for producing controllable ablation of spherical lesions with a diameter of up to 2 cm. The system is based on a solid-state energy source operating in the super high frequency (SHF is sdefined as being a frequency of between 3 and 30 GHz) region of the electromagnetic spectrum. Results obtained from preliminary tissue testing, performed on morbid tissue samples prepared in a laboratory environment, show repeatability in terms of shape and size of ablation, and demonstrate the ability to produce controlled ablation in morbid liver and kidney models.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Chen JC, Moriarty JA, Derbyshire A, Peters RD, Trachtenberg J, Bell SD, Doyle J, Arrelano R, Wright GA, Henkelman RM, Hinks RS, Lok S, Toi A, Kucharczyk W (2000) Prostate cancer: MRI imaging and thermometry during microwave thermal ablation—initial experience. Radiology 214:290–297

    Google Scholar 

  2. d’Arsonval M (1891) Action physiologique des courants alternatiifs. CR Soc Biol (Paris) 43:283

    Google Scholar 

  3. Erce C, Parks RW (2003) Interstitial ablative techniques for hepatic Tumours. Br J Surg 90:272–289

    Article  Google Scholar 

  4. Garcea G, Lloyd TD, Aylott C, Maddern G, Berry DP (2003) The emergent role of focal liver ablation techniques in the treatment of primary and secondary liver tumours. Eu J Cancer 29:2150–2164

    Article  Google Scholar 

  5. Goldberg SN, Solbiati L, Hahn PF, Cosman E, Conrad JE, Fogle R, Gazelle GS (1998) Large volume tissue ablation with radio frequency by using a clustered, internally cooled electrode technique: laboratory and clinical experience in liver metastases. Radiology 209(2):371–279

    Google Scholar 

  6. Haemmerich D, Lee Jr FT, Schutt DJ, Sampson LA, Webster JG, Fine JP, Mahvi DM (2005) Large volume radiofrequency ablation of ex vivo bovine liver with multiple cooled cluster electrodes. Radiology 234(2):563–568

    Article  Google Scholar 

  7. Heisterkamp J, Van hillegersberg R, Ijzermans JN (1999) Interstitial laser coagulation for hepatic tumours. Br J Surg 86:293–304

    Article  Google Scholar 

  8. Livraghi T, Goldberg SN, Monti F, Bizzini A, Lazzaroni S, Meloni F, Pellican? S, Solbiati L, Gazelle GS (1997) Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology 202(1):205–210

    Google Scholar 

  9. Neeman Z, Wood BJ (2002) Radiofrequency ablation beyond the liver. Tech Vasc Interv Radio 5(3):156–163

    Article  Google Scholar 

  10. Shock SA, Meredith K, Warner TF, Sampson LA, Wright AS, Winter III TC, Mahvi DM, Fine JP, Lee Jr FT (2004) Microwave ablation with loop antenna: in vivo porcine liver model. Radiology 231(1):143–149

    Article  Google Scholar 

  11. Skinner MG, Iizuka MN, Kolios MC, Sherar MD (1998) A theoretical comparison of energy sources-microwave, ultrasound and laser-for interstitial thermal therapy. Phys Med Biol 43:3535–3547

    Article  Google Scholar 

  12. Solbiati L, Goldberg SN, Ierace T, Livraghi T, Meloni T, Dellanoce M, Sironi S, Gazelle GS (1997) Hepatic metastases: percutaneous radio-frequency ablation with cooled-tip electrodes. Radiology 205(2):367–373

    Google Scholar 

  13. Strickland AD, Clegg PJ, Cronin NJ, Swift B, Festing M, West KP, Robertson GSM, Lloyd DM (2002) Experimental study of large-volume microwave ablation in the liver. Br J Surg 89:1003–1007

    Article  Google Scholar 

  14. Vargas HI, Dooley WC, Gardener RA, Gonzalez KD, Venegas R, Heywang-Käbrunner SH, Fenn AJ (2004) Focused microwave phased array thermotherapy for ablation of early-stage breast cancer: results of thermal dose escalation. Ann Surg Oncol 11(2):139–146

    Article  Google Scholar 

  15. Wright AS, Lee Jr FT, Mahvi DM (2003) Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol 10:275–283

    Article  Google Scholar 

  16. Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee FT (2005) Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology 236(1):132–139

    Article  Google Scholar 

Download references

Acknowledgments

C. H. would like to thank all the people who supported this work. Special thanks to Steve Morris, Izzat Darwazeh, John Bishop, Warren Jones, Robin Sloan, Simon Burdett, Andy Goodman, Richard Owen, Sabih Chaudhry and Graham Evans. The financial and clinical support of MDi Ltd is also gratefully acknowledged.

Author information

Authors and Affiliations

  1. MicroOncology Ltd, First Floor, Unit 6, Brassmill Enterprise Centre, Brassmill Lane, B&NES, Bath, BA1 3JN, UK

    C. P. Hancock, S. Chaudhry & A. M. Goodman

  2. Medical Devices Innovations Ltd (MDi), Daresbury Innovation Centre, Daresbury Science and Innovation Campus, Halton, Cheshire, WA4 4FS, UK

    P. Wall

Authors
  1. C. P. Hancock
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Chaudhry
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Wall
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. M. Goodman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. P. Hancock.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hancock, C.P., Chaudhry, S., Wall, P. et al. Proof of concept percutaneous treatment system to enable fast and finely controlled ablation of biological tissue. Med Bio Eng Comput 45, 531–540 (2007). https://doi.org/10.1007/s11517-007-0184-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11517-007-0184-z

Keywords