Skip to main content
SpringerLink
Log in

Temperature measurement on tissue surface during laser irradiation

  • Original Article
  • Published:
Medical & Biological Engineering & Computing Aims and scope Submit manuscript

Abstract

Tissue surface temperature distribution on the treatment site can serve as an indicator for the effectiveness of a photothermal therapy. In this study, both infrared thermography and theoretical simulation were used to determine the surface temperature distribution during laser irradiation of both gel phantom and animal tumors. Selective photothermal interaction was attempted by using intratumoral indocyanine green enhancement and irradiation via a near-infrared laser. An immunoadjuvant was also used to enhance immunological responses during tumor treatment. Monte Carlo method for tissue absorption of light and finite difference method for heat diffusion in tissue were used to simulate the temperature distribution during the selective laser photothermal interaction. An infrared camera was used to capture the thermal images during the laser treatment and the surface temperature was determined. Our findings show that the theoretical and experimental results are in good agreement and that the surface temperature of irradiated tissue can be controlled with appropriate dye and adjuvant enhancement. These results can be used to control the laser tumor treatment parameters and to optimize the treatment outcome. More importantly, when used with immunotherapy as a precursor of immunological responses, the selective photothermal treatment can be guided by the tissue temperature profiles both in the tumor and on the surface.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Barnes BR (1968) Diagnostic thermography. Appl Opt 7(9):1673–1685

    Article  Google Scholar 

  2. Boulnois JL (1986) Photophysical processes in recent medical laser development: a review. Lasers Med Sci 1:47–66

    Article  Google Scholar 

  3. Bryan FJ (1998) A reappraisal of the use of infrared thermal image analysis in medicine. IEEE Trans Med Imaging 17(6):1019–1027

    Article  MathSciNet  Google Scholar 

  4. Chen WR, Adams RL, Carubelli R, Nordquist RE (1997) Laser-photosensitizer assisted immunotherapy: a novel modality in cancer treatment. Cancer Lett 115:25–30

    Article  Google Scholar 

  5. Chen WR, Jeong SW, Lucroy MD, Wolf RF, Howard EW, Liu H, Nordquist RE (2003) Induced anti-tumor immunity against DMBA-4 metastatic mammary tumors in rats using a novel approach. Int J Cancer 107(6):1053–1057

    Article  Google Scholar 

  6. Chen WR, Ritchey JW, Bartels KE, Liu H, Nordquist RE (2002) Effect of different components of laser immunotherapy in treatment of metastatic tumors in rats. Cancer Res 62:4295–4299

    Google Scholar 

  7. Chen WR, Singhal AK, Liu H, Nordquist RE (2001) Laser immunotherapy induced antitumor immunity and its adoptive transfer. Cancer Res 61:459–461

    Google Scholar 

  8. Chen WR, Zhu W, Joseph RD, Liu H (1999) Nordquist RE long-term tumor resistance induced by laser photo-immunotherapy. Int J Cancer 81:808–812

    Article  Google Scholar 

  9. Cheong W, Welch AJ (1989) A model for optical and thermal analysis of laser balloon angioplasty. IEEE Trans Biomed Eng 36(12):1233–1243

    Article  Google Scholar 

  10. Crochet JJ, Gnyawali Surya C, Chen Yichao, Lemley EC, Bartels KE, Liu Hong, Chen WR (2006) Temperature distribution in selective laser-tissue interaction. J Biomed Opt 11(3):034031-1-10

  11. Hildebrandt B, Wust P, Ahlers O, Dieing A, Sreenivasa G, Kerner T, Felix R, Riess H (2002) The cellular and molecular basis of hyperthermia. Crit Rev Oncol Hematol 43:33–56

    Article  Google Scholar 

  12. Hirsch LR, Stafford RJ, Bankson JA, Sershen SR, Rivera B, Price RE, Hazle JD, Halas NJ, West JL (2003) Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci USA 100:13549–13554

    Article  Google Scholar 

  13. Jacques SL (1987) Optical properties of tissue in vitro. Lasers Surg Med 6:1–19

    Article  Google Scholar 

  14. Landsman MJ, Kwant G, Mook GA, Zijlstra WG (1976) Light-absorbing properties, stability, and spectral stabilization of indocyanine green. J Appl Physiol 40:575–583

    Google Scholar 

  15. Naylor MF, Chen WR, Teague TK, Perry L, Nordquist RE (2006) In situ photo immunotherapy: a tumor-directed treatment modality for melanoma. Br J Dermatol 155:1287–1292

    Article  Google Scholar 

  16. Orenstein A, Kostenich G, Tsur H, Kogan L, Malik Z (1995) Temperature monitoring during photodynamic therapy of skin tumors with topical 5-aminolevulinic acid application. Cancer Lett 93:227–232

    Article  Google Scholar 

  17. Partovi F, Izatt JA, Cothren RM, Kittrell C, Thomas JE, Strikwerde S, Kramer JR, Feld MS (1987) A model for thermal ablation of biological tissue using laser radiation. Lasers Surg Med 7:141–154

    Article  Google Scholar 

  18. Rich PB (2004) Infrared thermography: a rapid, portable, and accurate technique to detect experimental pneumothorex. J Surg Res 120(2):163–170

    Article  Google Scholar 

  19. Sagi A, Avraham S, Abraham K, Solange A (1992) Heating of biological tissue by laser irradiation: theoretical model. Opt Eng 31(7):1417–1424

    Article  Google Scholar 

  20. Scherbakov YuN, Yakunin AN, Yaroslavsky IV, Tuchin VV (1994) Thermal processes modeling during uncoagulating laser radiation interaction with multi-layer biotissue. 2. Numerical results. Opt Spectrosc 76(5):759–765

    Google Scholar 

  21. Scherbakov YuN, Yakunin AN, Yaroslavsky IV, Tuchin VV (1994) Thermal processes modeling during uncoagulating laser radiation interaction with multi-layer biotissue. 1. Theory and calculating models. Opt Spectrosc 76(5):754–758

    Google Scholar 

  22. Steketee J (1973) Spectral emissivity of skin and pericardium. Phys Med Biol 18(5):686–694

    Article  Google Scholar 

  23. Takashi M, Ozaki M, Nishiyama T, Imamura M, Kumazwa T (2000) Comparison of infrared thermometer with thermocouple for monitoring skin temperature. Crit Care Med 28(2):532–535

    Article  Google Scholar 

  24. TuchinVV, Scherbakov YN, Yakunin AN, Yaroslavsky IV (1995) Numerical technique for modeling of laser-induced hyperthermia. In: Laser-induced interstitial thermotherapy, SPIE Press PM 25, Bellingham, pp 100–113

  25. Xie W, Pip M, Jakobsen K, Paris C (2004) Evaluation of the ability of digital infrared imaging to detect vascular changes in experimental animal tumors. Int J Cancer 108:790–794

    Article  Google Scholar 

  26. Gao Y, Radhika S, Lu C-C, Suri JS, Laxminarayan S (2006) Breast image registration techniques: a survey Med Biol Eng Comput 44:15–26

    Article  Google Scholar 

  27. Zavisek M (2004) Breast cancer diagnostics using IR camera, PhD thesis

Download references

Acknowledgments

This research was supported in part by grants from the University of Central Oklahoma and the National Institute of Health (P20 RR016478 from the INBRE Program of the National Center for Research Resources, CA104773; RO1 GM 077185, GM 069589 and HL073087). The author (HL) would like to acknowledge the support of the Charles and Jean Smith Chair Endowment fund.

Author information

Authors and Affiliations

  1. Department of Physics, Oklahoma State University, Stillwater, OK, 74078, USA

    Surya C. Gnyawali & James P. Wicksted

  2. Biomedical Engineering Program, Department of Engineering and Physics, College of Mathematics and Science, University of Central Oklahoma, 100 North University Drive, Edmond, OK, 73034, USA

    Yicho Chen & Wei R. Chen

  3. Clinical Center for Tumor Therapy of 2nd Affiliated Hospital, and Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University, Medical College Road, Chongqing, 400016, China

    Feng Wu

  4. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, 74078, USA

    Kenneth E. Bartels

  5. Center for Bioengineering and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA

    Hong Liu

  6. Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, 43210, USA

    Surya C. Gnyawali & Chandan K. Sen

Authors
  1. Surya C. Gnyawali
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yicho Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Feng Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kenneth E. Bartels
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. James P. Wicksted
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hong Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Chandan K. Sen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Wei R. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wei R. Chen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gnyawali, S.C., Chen, Y., Wu, F. et al. Temperature measurement on tissue surface during laser irradiation. Med Bio Eng Comput 46, 159–168 (2008). https://doi.org/10.1007/s11517-007-0251-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11517-007-0251-5

Keywords

Search

Navigation