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Plasma detection of NO by a catheter

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Abstract

Nitric oxide (NO) released by endothelial cells in response to hemodynamic shear stress is a key controller molecule of the vascular functions and antiatherogenic mechanisms. Endothelial dysfunction is associated with increased cardiovascular events. Therefore, several indirect techniques have been employed to evaluate endothelial function or NO bioavailability. However, a growing body of evidences suggests limitations of the indirect methods for evaluation of NO bioavailability. In years, it has been considered that NO is immediately oxidized or inactivated in blood stream. However, recent studies suggest that NO remain active in blood stream, causing remote biological response. Therefore, measuring plasma NO concentration directly in the circulation will contribute to clarify the kinetics and physiological roles of NO and to evaluate endothelial function. In this article, the measurement of plasma NO concentration using a newly developed catheter-type NO sensor will be described.

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References

  1. Adrie C, Bloch KD, Moreno PR et al (1996) Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation 94:1919–1926

    Article  CAS  PubMed  Google Scholar 

  2. Awolesi MA, Sessa WC, Sumpio BE (1995) Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J Clin Invest 96:1449–1454

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Axelsson KL, Wikberg JES, Andersson RGG (1979) Relationship between nitroglycerin, cyclic GMP and relaxation of vascular smooth muscle. Life Sci 24:1779–1786

    Article  CAS  PubMed  Google Scholar 

  4. Bache RJ (1998) Vasodilator reserve :a functional assessment of coronary health. Circulation 98:1257–1260

    Article  CAS  PubMed  Google Scholar 

  5. Behrendt D, Ganz P (2002) Endothelial function: from vascular biology to clinical applications. Am J Cardiol 90:40L–48L

    Article  CAS  PubMed  Google Scholar 

  6. Brevetti G, Silvestro A, Schiano V et al (2003) Endothelial dysfunction and cardiovascular risk prediction in peripheral artery disease: additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation 108:2093–2098

    Article  PubMed  Google Scholar 

  7. Broere A, Van Den Meiracker AH, Boomsma F et al (1998) Human renal and systemic hemodynamic, natriuretic, and neurohumoral responses to different doses of L-NAME. Am J Physiol 257:F870–F877

    Google Scholar 

  8. Buga GM, Gold ME, Fukuto JM et al (1991) Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension 17:187–193

    Article  CAS  PubMed  Google Scholar 

  9. Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840–844

    Article  CAS  PubMed  Google Scholar 

  10. Canty JM Jr, Schwartz JS (1994) Nitric oxide mediates flow-dependent epicardial coronary vasodilation to changes in pulse frequency but not mean flow in conscious dogs. Circulation 89:375–384

    Article  CAS  PubMed  Google Scholar 

  11. Cardillo C, Kilcoyne CM, Quyyumi AA et al (1998) Selective defect in nitric oxide synthesis may explain the impaired endothelium-dependent vasodilation in patients with essential hypertension. Circulation 97:851–856

    Article  CAS  PubMed  Google Scholar 

  12. Celermajer DS, Sorensen KE, Gooch VM (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340:1111–1115

    Article  CAS  PubMed  Google Scholar 

  13. Celermajer DS, Adams MR, Clarkson P et al (1996) Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med 334:150–154

    Article  CAS  PubMed  Google Scholar 

  14. Chilian WM, Eastham CL, Marcus ML (1986) Microvascular distribution of coronary vascular resistance in beating left ventricle. Am J Physiol 251:H779–H788

    CAS  PubMed  Google Scholar 

  15. De Keulenaer G, Chappell DC, Ishizaka N et al (1998) Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase. Circ Res 82:1094–1101

    Article  PubMed  Google Scholar 

  16. Fathi R, Haluska B, Isbel N et al (2004) The relative importance of vascular structure and function in predicting cardiovascular events. J Am Coll Cardiol 43:616–623

    Article  PubMed  Google Scholar 

  17. Fox-Robichaud A, Payne D, Hasan SU et al (1998) Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds. J Clin Invest 101:2497–2505

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Frick M, Suessenbacher A, Alber HF et al (2005) Prognostic value of brachial artery endothelial function and wall thickness. J Am Coll Cardiol 46:1006–1010

    Article  PubMed  Google Scholar 

  19. Frostell C, Fratacci MD, Wain JC et al (1991) Inhaled nitric oxide: a selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 83:2038–2047

    Article  CAS  PubMed  Google Scholar 

  20. Fukai T, Folz RJ, Landmesser U et al (2002) Extracellular superoxide dismutase and cardiovascular disease. Cardiovasc Res 55:239–249

    Article  CAS  PubMed  Google Scholar 

  21. Gianetti J, Bevilacqua S, De Caterina R (2002) Inhaled nitric oxide: more than a selective pulmonary vasodilator. Eur J Clin Invest 32:628–635

    Article  CAS  PubMed  Google Scholar 

  22. Gokce N, Keaney JF Jr, Hunter LM et al (2002) Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation 105:1567–1572

    Article  PubMed  Google Scholar 

  23. Gokce N, Keaney JF Jr, Hunter LM (2003) Predictive value of noninvasively determined endothelial dysfunction for long term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol 41:1769–1775

    Article  PubMed  Google Scholar 

  24. Goto M, Flynn AE, Doucette JW et al (1991) Cardiac contraction affects deep myocardial vessels predominantly. Am J Physiol 261:H1417–H1429

    CAS  PubMed  Google Scholar 

  25. Goto M, VanBavel E, Giezeman MJMM et al (1996) Vasodilatory effect of pulsatile pressure on coronary resistance vessels. Circ Res 79:1039–1046

    Article  CAS  PubMed  Google Scholar 

  26. Griendling KK, Minieri CA, Ollerenshaw JD et al (1994) Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74:1141–1148

    Article  CAS  PubMed  Google Scholar 

  27. Griendling KK, Sorescu D, Lassegue B et al (2000) Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol 20:2175–2183

    Article  CAS  PubMed  Google Scholar 

  28. Griendling KK, FitzGerald GA (2003) Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation 108:2034–2040

    Article  PubMed  Google Scholar 

  29. Hishikawa K, Nakai T, Suzuki H et al (1992) Transmural pressure inhibits nitric oxide release from human endothelial cells. Eur J Pharmacol 215:329–331

    Article  CAS  PubMed  Google Scholar 

  30. Hoffman JIE (1987) Transmural myocardial perfusion. Prog Cardiovasc Dis 29:429–464

    Article  CAS  PubMed  Google Scholar 

  31. Hoffman JIE, Spaan JAE (1990) Pressure-flow relations in coronary circulation. Physiol Rev 70:331–390

    CAS  PubMed  Google Scholar 

  32. Hoffman JIE (1995) Heterogeneity of myocardial blood flow. Basic Res Cardiol 90:103–111

    Article  CAS  PubMed  Google Scholar 

  33. Hutcheson IR, Griffith TM (1991) Release of endothelium-derived relaxing factor is modulated both by frequency and amplitude of pulsatile flow. Am J Physiol 261:H257–H262

    CAS  PubMed  Google Scholar 

  34. Imanishi T, Kobayashi K, Kuroi A et al (2006) Effects of angiotensin II on nitric oxide bioavailability evaluated using a catheter-type nitric oxide sensor. Hypertension 48:1058–1065

    Article  CAS  PubMed  Google Scholar 

  35. Ji Y, Han Y, Diao J et al (2003) Rabbit aortic endothelial dysfunction by low-density lipoprotein is attenuated by l-arginine, l-ascorbate and pyridoxine. Br J Pharmacol 140:1272–1282

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Kajiya F, Goto M (1999) Integrative physiology of coronary microcirculation. Jpn J Physiol 49:229–241

    Article  CAS  PubMed  Google Scholar 

  37. Katsuki S, Murad F (1977) Regulation of adenosine cyclic 3′,5′-monophosphate and guanosine cyclic 3′,5′-monophosphate levels and contractility in bovine tracheal smooth muscle. Mol Pharmacol 13:330–341

    CAS  PubMed  Google Scholar 

  38. Kinlay S, Libby P, Ganz P (2001) Endothelial function and coronary artery disease. Curr Opin Lipidol 12:383–389

    Article  CAS  PubMed  Google Scholar 

  39. Kleschyov AL, Oelze M, Daiber A et al (2003) Does nitric oxide mediate the vasodilator activity of nitroglycerin? Circ Res 93:e104–e112

    Article  CAS  PubMed  Google Scholar 

  40. Koller A, Sun D, Kaley G (1993) Role of shear stress and endothelial prostaglandins in flow- and viscosity-induced dilation of arterioles in vitro. Circ Res 72:1276–1284

    Article  CAS  PubMed  Google Scholar 

  41. Kuo L, Davis MJ, Chilian WM (1990) Endothelium-dependent, flow-induced dilation of isolated coronary arterioles. Am J Physiol 259:H1063–H1070

    CAS  PubMed  Google Scholar 

  42. Kuvin JT, Karas RH (2003) Clinical utility of endothelial function testing: ready for prime time? Circulation 107:3243–3247

    Article  PubMed  Google Scholar 

  43. Lamontagne D, Pohl U, Busse R (1992) Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed. Circ Res 70:123–130

    Article  CAS  PubMed  Google Scholar 

  44. Lee JS, Adrie C, Jacob HJ et al (1996) Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res 78:337–342

    Article  CAS  PubMed  Google Scholar 

  45. Liao JC, Hein TW, Vaughn MW et al (1999) Intravascular flow decreases erythrocyte consumption of nitric oxide. Proc Natl Acad Sci USA 96:8757–8761

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Libby P, Ridker PM, Maseri A (2002) Inflammation and atherosclerosis. Circulation 115:1135–1143

    Article  Google Scholar 

  47. Liu X, Huang Y, Pokreisz P et al (2007) Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion. J Am Coll Cardiol 50:808–817

    Article  PubMed  Google Scholar 

  48. Ludmer PL, Selwyn AP, Shook TL et al (1986) Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 315:1046–1051

    Article  CAS  PubMed  Google Scholar 

  49. Luscher TF, Tanner FC, Tschudi MR et al (1993) Endothelial dysfunction in coronary artery disease. Annu Rev Med 44:395–418

    Article  CAS  PubMed  Google Scholar 

  50. Malinski T, Taha Z (1992) Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor. Nature 358:676–678

    Article  CAS  PubMed  Google Scholar 

  51. Marcus ML, Chilian WM, Kanatsuka H et al (1990) Understanding the coronary circulation through studies at the microvascular level. Circulation 82:1–7

    Article  CAS  PubMed  Google Scholar 

  52. Merkus D, Vergroesen I, Hiramatsu O et al (2001) Stenosis differentially affects subendocardial and subepicardial arterioles in vivo. Am J Physiol 280:1674–1682

    Google Scholar 

  53. Mochizuki S, Himi N, Miyasaka T et al (2002) Evaluation of basic performance and applicability of a newly developed in vivo nitric oxide sensor. Physiol Meas 23:261–268

    Article  PubMed  Google Scholar 

  54. Mochizuki S, Miyasaka T, Goto M et al (2003) Measurement of acetylcholine-induced endothelium-derived nitric oxide in aorta using a newly developed catheter-type nitric oxide sensor. Biochem Biophys Res Commun 306:505–508

    Article  CAS  PubMed  Google Scholar 

  55. Mohri M, Egashira K, Tagawa T et al (1997) Basal release of nitric oxide is decreased in the coronary circulation in patients with heart failure. Hypertension 30:50–56

    Article  CAS  PubMed  Google Scholar 

  56. Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: physlology pathology and pharmacology. Pharmacol Rev 43:109–142

    CAS  PubMed  Google Scholar 

  57. Neishi Y, Mochizuki S, Miyasaka T et al (2005) Evaluation of bioavailability of nitric oxide in coronary circulation by direct measurement of plasma nitric oxide concentration. Proc Natl Acad Sci USA 102:11456–11461

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Neri Serneri GG, Boddi M, Modesti PA et al (2003) Immunomediated and ischemia-independent inflammation of coronary microvessels in unstable angina. Circ Res 92:1359–1366

    Article  CAS  PubMed  Google Scholar 

  59. Neviere R, Guery B, Mordon S et al (2000) Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats. Am J Physiol 278:H1783–H1790

    CAS  Google Scholar 

  60. Nickenig G, Harrison DG (2002) The AT1-type angiotensin receptor in oxidative stress and atherogenesis: Part I: oxidative stress and atherogenesis. Circulation 105:393–396

    Article  CAS  PubMed  Google Scholar 

  61. Nickenig G, Harrison DG (2002) The AT1-type angiotensin receptor in oxidative stress and atherogenesis: Part II: AT1 receptor regulation. Circulation 105:530–536

    Article  CAS  PubMed  Google Scholar 

  62. Nong Z, Hoylaerts M, Van Pelt N et al (1997) Nitric oxide inhalation inhibits platelet aggregation and platelet-mediated pulmonary thrombosis in rats. Circ Res 81:865–869

    Article  CAS  PubMed  Google Scholar 

  63. Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT et al (1991) Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 338:1173–1174

    Article  CAS  PubMed  Google Scholar 

  64. Perticone F, Ceravolo R, Pujia A et al (2001) Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 104:191–196

    Article  CAS  PubMed  Google Scholar 

  65. Pinsky DJ, Patton S, Mesaros S et al (1997) Mechanical transduction of nitric oxide synthesis in the beating heart. Circ Res 81:372–379

    Article  CAS  PubMed  Google Scholar 

  66. Pohl U, Busse R, Kuon E et al (1986) Pulsatile perfusion stimulates the release of endothelial autacoids. J Appl Cardiol 1:215–235

    CAS  Google Scholar 

  67. Prasad A, Zhu J, Halcox JP et al (2002) Predisposition to atherosclerosis by infections: role of endothelial dysfunction. Circulation 106:184–190

    Article  PubMed  Google Scholar 

  68. Quyyumi AA, Dakak N, Andrews NP et al (1995) Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation 92:320–326

    Article  CAS  PubMed  Google Scholar 

  69. Quyyumi AA, Mulcahy D, Andrews NP et al (1997) Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia: comparison of acetylcholine and substance P. Circulation 95:104–110

    Article  CAS  PubMed  Google Scholar 

  70. Rabbany SY, Funai JT, Noordergraaf A (1994) Pressure generation in a contracting myocyte. Heart Vessels 9:169–174

    Article  CAS  PubMed  Google Scholar 

  71. Rassaf T, Preik M, Kleinbongard P et al (2002) Evidence for in vivo transport of bioactive nitric oxide in human plasma. J Clin Invest 109:1241–1248

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Recchia FA, Senzaki H, Saeki A et al (1996) Pulse pressure-related changes in coronary flow in vivo are modulated by nitric oxide and adenosine. Circ Res 79:849–856

    Article  CAS  PubMed  Google Scholar 

  73. Recchia FA, Byrne BJ, Kass DA (1999) Sustained vessel dilation induced by increased pulsatile perfusion of porcine carotid arteries in vitro. Acta Physiol Scand 166:15–21

    Article  CAS  PubMed  Google Scholar 

  74. Ross R, Glomset JA (1973) Atherosclerosis and the arterial smooth muscle cell: proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science 180:1332–1339

    Article  CAS  PubMed  Google Scholar 

  75. Ross R (1999) Atherosclerosis:an inflammatory disease. N Engl J Med 340:115–126

    Article  CAS  PubMed  Google Scholar 

  76. Shibuki K (1990) An electrochemical microprobe for detecting nitric oxide release in brain tissue. Neurosci Res 9:69–76

    Article  CAS  PubMed  Google Scholar 

  77. Sorop O, Spaan JAE, VanBavel E (2002) Pulsation-induced dilation of subendocardial and subepicardial arterioles:effect on vasodilator sensitivity. Am J Physiol 282:H311–H319

    CAS  Google Scholar 

  78. Sorop O, Spaan JAE, Sweeney TE et al (2003) Effect of steady versus oscillating flow on porcine coronary arterioles:involvement of NO and superoxide anion. Circ Res 92:1344–1351

    Article  CAS  PubMed  Google Scholar 

  79. Stepp DW, Nishikawa Y, Chilian WM (1999) Regulation of shear stress in the canine coronary microcirculation. Circulation 100:1555–1561

    Article  CAS  PubMed  Google Scholar 

  80. Toyota E, Goto M, Nakamoto H et al (1999) Endothelium-derived nitric oxide enhances the effect of intraaortic balloon pumping on diastolic coronary flow. Ann Thorac Surg 67:1254–1261

    Article  CAS  PubMed  Google Scholar 

  81. Toyota E, Fujimoto K, Ogasawara Y et al (2002) Dynamic changes in three-dimensional architecture and vascular volume of transmural coronary microvasculature between diastolic- and systolic-arrested rat hearts. Circulation 105:621–626

    Article  PubMed  Google Scholar 

  82. Toyota E, Ogasawara Y, Hiramatsu O et al (2005) Dynamics of flow velocities in endocardial and epicardial coronary arterioles. Am J Physiol 288:H1598–H1603

    CAS  Google Scholar 

  83. Vallance P, Patton S, Bhagat K et al (1995) Direct measurement of nitric oxide in human beings. Lancet 345:153–154

    Article  Google Scholar 

  84. Vita JA, Treasure CB, Nabel EG et al (1990) Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 81:491–497

    Article  CAS  PubMed  Google Scholar 

  85. Westerhof N, Boer C, Lamberts RR et al (2006) Cross-talk between cardiac muscle and coronary vasculature. Physiol Rev 86:1263–1308

    Article  CAS  PubMed  Google Scholar 

  86. Widlanksy ME, Gokce N, Keaney JF et al (2003) The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42:1149–1160

    Article  Google Scholar 

  87. Yada T, Hiramatsu O, Kimura A et al (1993) In vivo observation of subendocardial microvessels of the beating porcine heart using a needle-probe videomicroscope with a CCD camera. Circ Res 72:939–946

    Article  CAS  PubMed  Google Scholar 

  88. Yada T, Hiramatsu O, Kimura A et al (1995) Direct in vivo observation of subendocardial arteriolar response during reactive hyperemia. Circ Res 77:622–631

    Article  CAS  PubMed  Google Scholar 

  89. Yada T, Goto M, Hiramatsu O et al (2003) In vivo visualization of subendocardial arteriolar response in renovascular hypertensive hearts. Am J Physiol 284:H1785–H1792

    CAS  Google Scholar 

  90. Yada T, Shimokawa H, Hiramatsu O et al (2006) Cardioprotective role of endogenous hydrogen peroxide during ischemia-reperfusion injury in canine coronary microcirculation in vivo. Am J Physiol 291:H1138–H1146

    CAS  Google Scholar 

  91. Yamasawa T (2007) Dynamics of blood nitric oxide level during nitric oxide inhalation. Kawasaki Med J 33:101–106

    CAS  Google Scholar 

  92. Yeboah J (2007) Brachial flow-mediated dilation predicts incident cardiovascular events in older adults. The cardiovascular health study. Circulation 115:2390–2397

    Article  PubMed  Google Scholar 

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Acknowledgments

Drs. Yoji Neishi, Takahiro Kawamoto, Takashi Akasaka, Kiyoshi Yoshida, Takahiko Yamasawa, Eiichiro Inagaki, Sohei Hamanaka, Kazuo Tanemoto, and Yasuo Ogasawara made important contributions to the works presented in this manuscript. This work was supported in part by grants-in-aid from the Japanese Ministry of Education, Science, Sports, Culture, and Technology, Tokyo, Japan No. 19300197 (M.G.).

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  1. Department of Medical Engineering, Kawasaki University of Medical Welfare, 288, Matsushima, Kurashiki, Okayama, 701-0193, Japan

    Masami Goto & Seiichi Mochizuki

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  1. Masami Goto
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Correspondence to Masami Goto.

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Goto, M., Mochizuki, S. Plasma detection of NO by a catheter. Med Biol Eng Comput 46, 509–516 (2008). https://doi.org/10.1007/s11517-008-0333-z

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