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Reexamination of risk criteria in dengue patients using the self-organizing map

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Abstract

Even though the World Health Organization criteria’s for classifying the dengue infection have been used for long time, recent studies declare that several difficulties have been faced by the clinicians to apply these criteria. Accordingly, many studies have proposed modified criteria to identify the risk in dengue patients based on statistical analysis techniques. None of these studies utilized the powerfulness of the self-organized map (SOM) in visualizing, understanding, and exploring the complexity in multivariable data. Therefore, this study utilized the clustering of the SOM technique to identify the risk criteria in 195 dengue patients. The new risk criteria were defined as: platelet count less than or equal 40,000 cells per mm3, hematocrit concentration great than or equal 25% and aspartate aminotransferase (AST) rose by fivefold the normal upper limit for AST/alanine aminotransfansferase (ALT) rose by fivefold the normal upper limit for ALT. The clusters analysis indicated that any dengue patient fulfills any two of the risk criteria is consider as high risk dengue patient.

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Acknowledgement

This work is financially supported by a Malaysian Ministry of Science Technology and Innovation (MOSTI) Science Fund Project No. 11-02-03-1014 and postgraduate research Fund (PPP) No. PS138-2008B, University of Malaya.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Tarig Faisal & Fatimah Ibrahim

  2. Faculty of Electrical Engineering, Universiti Teknologi Mara, 40450, Shah Alam, Selangor, Malaysia

    Mohd Nasir Taib

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  1. Tarig Faisal
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  2. Mohd Nasir Taib
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  3. Fatimah Ibrahim
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Correspondence to Fatimah Ibrahim.

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Faisal, T., Taib, M.N. & Ibrahim, F. Reexamination of risk criteria in dengue patients using the self-organizing map. Med Biol Eng Comput 48, 293–301 (2010). https://doi.org/10.1007/s11517-009-0561-x

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