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Microwave applicator for hyperthermia treatment on in vivo melanoma model

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Abstract

In this article, we evaluated a planar microwave applicator for in vivo superficial hyperthermia treatments on small tumors in the mouse mimicking treatments for human neoplasms. The design of the applicator, was challenged by the small dimensions of the tumors and unwanted diffusion of heating in the tumor-bearing animals. The required solution was to limit the penetration of microwaves in the depth of the tissue maintaining the full efficacy of hyperthermia. The study was firstly performed by computer simulations of SAR distribution inside a flat homogeneous phantom, considering various thicknesses of the integrated water bolus. Simulations, validated by the measurements, were also used to evaluate the impedance matching. Further tests were performed on homogeneous agar phantom to simulate the temperature distribution in the biological tissue and to preliminary assess the possible modality and schedule of microwave hyperthermia delivery. The in vivo experiments showed the evidence of direct microwave-induced heating and damage of the melanoma tissue in a range of penetration coherent both with computer simulations and phantom studies. The described approach appears perspective for designing limited-microwave-delivery applicators tailored for treatments of human superficial tumors and pre-tumoral lesions.

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Acknowledgments

This study is funded by the Grant Agency of the Academy of Sciences of the Czech Republic IAA500200510, Institutional Research Concepts No.AV0Z50200510, by the Grant Agency of the Czech Republic, Grant No. 102/08/H081 and by the research program MSM6840770012 “Transdisciplinary Research in the Area of Biomedical Engineering II.

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Authors and Affiliations

  1. Department of Electromagnetic Field, Czech Technical University in Prague, Prague, Czech Republic

    Paolo Togni & Jan Vrba

  2. Department of Immunology and Gnotobiology, Institute of Microbiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Luca Vannucci

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  1. Paolo Togni
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  2. Jan Vrba
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  3. Luca Vannucci
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Correspondence to Paolo Togni.

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Togni, P., Vrba, J. & Vannucci, L. Microwave applicator for hyperthermia treatment on in vivo melanoma model. Med Biol Eng Comput 48, 285–292 (2010). https://doi.org/10.1007/s11517-009-0563-8

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  • DOI: https://doi.org/10.1007/s11517-009-0563-8

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