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Localization of coherent sources by simultaneous MEG and EEG beamformer

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Abstract

Simultaneous magnetoencephalography (MEG) and electroencephalography (EEG) analysis is known generally to yield better localization performance than a single modality only. For simultaneous analysis, MEG and EEG data should be combined to maximize synergistic effects. Recently, beamformer for simultaneous MEG/EEG analysis was proposed to localize both radial and tangential components well, while single modality analyses could not detect them, or had relatively higher location bias. In practice, most interesting brain sources are likely to be activated coherently; however, conventional beamformer may not work properly for such coherent sources. To overcome this difficulty, a linearly constrained minimum variance (LCMV) beamformer may be used with a source suppression strategy. In this work, simultaneous MEG/EEG LCMV beamformer using source suppression was formulated firstly to investigate its capability over various suppression strategies. The localization performance of our proposed approach was examined mainly for coherent sources and compared thoroughly with the conventional simultaneous and single modality approaches, over various suppression strategies. For this purpose, we used numerous simulated data, as well as empirical auditory stimulation data. In addition, some strategic issues of simultaneous MEG/EEG analysis were discussed. Overall, we found that our simultaneous MEG/EEG LCMV beamformer using a source suppression strategy is greatly beneficial in localizing coherent sources.

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Acknowledgments

This work was supported by the Korea Research Council of Fundamental Science and Technology (KRCF) through the Basic Research Project managed by KRISS. We would like to thank Dr. Haruta at Yokogawa Electric Corp. for assistance in the MEG and EEG data acquisition.

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Authors and Affiliations

  1. School of Information and Communications, Gwangju Institute of Science and Technology, Gwangju, 500-712, Republic of Korea

    Jun Hee Hong, Minkyu Ahn & Sung Chan Jun

  2. Korea Research Institute of Standards and Science (KRISS), Daejeon, 305-340, Republic of Korea

    Kiwoong Kim

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  1. Jun Hee Hong
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  2. Minkyu Ahn
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  4. Sung Chan Jun
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Correspondence to Sung Chan Jun.

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Hong, J.H., Ahn, M., Kim, K. et al. Localization of coherent sources by simultaneous MEG and EEG beamformer. Med Biol Eng Comput 51, 1121–1135 (2013). https://doi.org/10.1007/s11517-013-1092-z

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  • DOI: https://doi.org/10.1007/s11517-013-1092-z

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