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Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients

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Abstract

Ozone major autohemotherapy is effective in reducing the symptoms of multiple sclerosis (MS) patients, but its effects on brain are still not clear. In this work, we have monitored the changes in the cerebrovascular pattern of MS patients and normal subjects during major ozone autohemotherapy by using near-infrared spectroscopy (NIRS) as functional and vascular technique. NIRS signals are analyzed using a combination of time, time–frequency analysis and nonlinear analysis of intrinsic mode function signals obtained from empirical mode decomposition technique. Our results show that there is an improvement in the cerebrovascular pattern of all subjects indicated by increasing the entropy of the NIRS signals. Hence, we can conclude that the ozone therapy increases the brain metabolism and helps to recover from the lower activity levels which is predominant in MS patients.

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Acknowledgments

Part of the study was founded by the Scientific Society of Oxygen Ozone Therapy (SIOOT).

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Authors and Affiliations

  1. Biolab, Department of Electronics and Telecommunications, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy

    Filippo Molinari & Daniele Rimini

  2. “Un Passo Insieme” ONLUS Foundation, Valdellatorre, Turin, Italy

    William Liboni

  3. Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Clementi, 599489, Singapore

    U. Rajendra Acharya

  4. Department of Biomedical Engineering, SIM University, Clementi, Singapore

    U. Rajendra Acharya

  5. Scientific Society of Oxygen Ozone Therapy (SIOOT), Gorle, BG, Italy

    Marianno Franzini, Sergio Pandolfi & Francesco Vaiano

  6. Geriatric and Emergency Medicine, Postgraduate School in Emergency Medicine, University of Pavia, Pavia, Italy

    Giovanni Ricevuti

  7. Geriatric Division, ASP – IDR S. Margherita, Pavia, Italy

    Giovanni Ricevuti

  8. Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy

    Luigi Valdenassi

  9. “Kaos” ONLUS Foundation, Turin, Italy

    Vincenzo Simonetti

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  1. Filippo Molinari
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Correspondence to Filippo Molinari.

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Molinari, F., Rimini, D., Liboni, W. et al. Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients. Med Biol Eng Comput 55, 1163–1175 (2017). https://doi.org/10.1007/s11517-016-1580-z

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  • DOI: https://doi.org/10.1007/s11517-016-1580-z

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