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3D structural complexity analysis of cerebellum in Chiari malformation type I

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Abstract

Chiari malformation type I (CM-I), described by a descent of the cerebellar tonsils, is assumed to be a neurological developmental disorder. The aim of the present study was to investigate morphological variance in cerebellar sub-structures, including gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF), using magnetic resonance (MR) images with three-dimensional (3D) fractal dimension (FD) analysis in patients with CM-I. MRI data of 16 patients and 15 control subjects were obtained, and structural complexity analyses were performed using a box-counting FD algorithm. Results showed that patients with CM-I had significantly reduced FD values for WM and CSF in comparison with controls, and statistically significant differences in cerebellar GM and CSF volumes between patients and controls were found. Moreover, a significant difference was not found between the WM volumes. This may suggest that there are changes in structural complexity in WM even when its volume is unaffected. We conclude that the findings of this preliminary study indicate the possibility of using FD analysis to understand the pathophysiology of CM-I in patients.

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Acknowledgements

This research was supported by the Fatih University Research and Development Management Office under project number P58011501_B.

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Authors and Affiliations

  1. Independent Researcher, Adnan Kahveci Mh. Konak Cd., Beyaz İnci Evleri B Blok No:19, 34528 Beylikdüzü, Istanbul, Turkey

    Engin Akar

  2. Independent Researcher, Istanbul, Turkey

    Sadık Kara

  3. Department of Neurosurgery, Medicana International Hospital, Istanbul, Turkey

    Hidayet Akdemir

  4. Department of Radiology, Mehmet Akif Ersoy Cardio-Thoracic Surgery Training and Research Hospital, Istanbul, Turkey

    Adem Kırış

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  1. Engin Akar
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Correspondence to Engin Akar.

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Akar, E., Kara, S., Akdemir, H. et al. 3D structural complexity analysis of cerebellum in Chiari malformation type I. Med Biol Eng Comput 55, 2169–2182 (2017). https://doi.org/10.1007/s11517-017-1661-7

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  • DOI: https://doi.org/10.1007/s11517-017-1661-7

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