Skip to main content

Advertisement

Springer Nature Link
Log in

Power spectra prognostic aspects of impulsive eye movement traces in superior vestibular neuritis

  • Original Article
  • Published:
Medical & Biological Engineering & Computing Aims and scope Submit manuscript

Abstract

Since usefulness of power spectra (PS) analysis was demonstrated in many fields of electrophysiology, the aims of the present study were to evaluate differences in frequency domain values of eye velocity traces between a group of 60 healthy subjects (HC) and 35 matched superior vestibular neuritis (VN) patients and to determine prognostic aspects of such values in terms of superior VN recovery. PS calculated on video head impulse test traces was compared between HC and during the acute stage of vertigo (T1) and after 3 months (T2) in superior VN patients. A multiple regression and desirability model between Δ (T2gain − T1gain) vestibulo-ocular reflex (VOR) gain and five prognostic factors were employed. Significant PS differences within the 7.8–16.6 Hz domain were found between superior VN and HC. A significant negative correlation was found between the 7.8–16.6 Hz domain unitary PS value and Δ VOR gain (β = − 0.836). The desirability model depicted a cutoff value of the unitary PS equal to 1.82 in order to obtain a Δ VOR gain rate at least equal to 0.1. Present findings could be a further step for monitoring those superior VN patients with systemic risk factors and high risk of VOR incomplete recovery.

In the top left, healthy control (HC) and superior vestibular neuritis (VN) subjects were screened by means of video head impulse test. In the top right, significant differences in power spectra values were depicted within the 7.8–16.6 Hz domain when comparing the two groups of subjects. In the bottom center, the desirability model depicts a cutoff value of the power spectra equal to 1.82 in order to obtain a Δ vestibulo-ocular reflex gain rate at least equal to 0.1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Tarnutzer AA, Berkowitz AL, Robinson KA, Hsieh YH, Newman-Toker DE (2011) Does my dizzy patient have a stroke? A systematic review of bedside diagnosis in acute vestibular syndrome. CMAJ 183(9):E571–E592. https://doi.org/10.1503/cmaj.100174

    Article  PubMed  PubMed Central  Google Scholar 

  2. Mantokoudis G, Tehrani AS, Wozniak A, Eibenberger K, Kattah JC, Guede CI et al (2015) VOR gain by head impulse video-oculography differentiates acute vestibular neuritis from stroke. Otol Neurotol 36(3):457–465. https://doi.org/10.1097/mao.0000000000000638

    Article  PubMed  Google Scholar 

  3. Halmagyi GM, Weber KP, Curthoys IS (2010) Vestibular function after acute vestibular neuritis. Restor Neurol Neurosci 28(1):37–46. https://doi.org/10.3233/rnn-2010-0533

    Article  CAS  PubMed  Google Scholar 

  4. Cousins S, Kaski D, Cutfield N, Arshad Q, Ahmad H, Gresty MA et al (2017) Predictors of clinical recovery from vestibular neuritis: a prospective study. Ann Clin Transl Neurol 4(5):340–346. https://doi.org/10.1002/acn3.386

    Article  PubMed  PubMed Central  Google Scholar 

  5. Adamec I, Krbot Skoric M, Ozretic D, Habek M (2014) Predictors of development of chronic vestibular insufficiency after vestibular neuritis. J Neurol Sci 347(1–2):224–228. https://doi.org/10.1016/j.jns.2014.10.001

    Article  PubMed  Google Scholar 

  6. Newman-Toker DE, Curthoys IS, Halmagyi GM (2015) Diagnosing stroke in acute vertigo: the HINTS family of eye movement tests and the future of the “eye ECG”. Semin Neurol 35(5):506–521. https://doi.org/10.1055/s-0035-1564298

    Article  PubMed  Google Scholar 

  7. Martin-Sanz E, Rueda A, Esteban-Sanchez J, Yanes J, Rey-Martinez J, Sanz-Fernandez R (2017) Vestibular restoration and adaptation in vestibular neuritis and Ramsay hunt syndrome with vertigo. Otol Neurotol 38(7):e203–e2e8. https://doi.org/10.1097/mao.0000000000001468

    Article  PubMed  Google Scholar 

  8. MacDougall HG, Weber KP, McGarvie LA, Halmagyi GM, Curthoys IS (2009) The video head impulse test: diagnostic accuracy in peripheral vestibulopathy. Neurology. 73(14):1134–1141. https://doi.org/10.1212/WNL.0b013e3181bacf85

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Newman-Toker DE, Kattah JC, Alvernia JE, Wang DZ (2008) Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis. Neurology. 70(24 Pt 2):2378–2385. https://doi.org/10.1212/01.wnl.0000314685.01433.0d

    Article  PubMed  Google Scholar 

  10. Rey-Martinez J (2017) Validity of wavelet transforms for analysis of video head impulse test (vHIT) results. Eur Arch Otorhinolaryngol 274(12):4241–4249. https://doi.org/10.1007/s00405-017-4755-9

    Article  PubMed  Google Scholar 

  11. Kerber KA, Morgenstern LB, Meurer WJ, McLaughlin T, Hall PA, Forman J et al (2011) Nystagmus assessments documented by emergency physicians in acute dizziness presentations: a target for decision support? Acad Emerg Med Off J Soc Acad Emerg Med 18(6):619–626. https://doi.org/10.1111/j.1553-2712.2011.01093.x

    Article  Google Scholar 

  12. Cain ME, Ambos HD, Witkowski FX, Sobel BE (1984) Fast-Fourier transform analysis of signal-averaged electrocardiograms for identification of patients prone to sustained ventricular tachycardia. Circulation. 69(4):711–720

    Article  CAS  Google Scholar 

  13. Dingli K, Assimakopoulos T, Fietze I, Witt C, Wraith PK, Douglas NJ (2002) Electroencephalographic spectral analysis: detection of cortical activity changes in sleep apnoea patients. Eur Respir J 20(5):1246–1253

    Article  CAS  Google Scholar 

  14. Micarelli A, Viziano A, Bruno E, Micarelli E, Alessandrini M (2016) Vestibular impairment in multiple chemical sensitivity: component analysis findings. J Vestib Res 26(5–6):459–468. https://doi.org/10.3233/ves-160594

    Article  Google Scholar 

  15. Bruno E, De Padova A, Napolitano B, Marroni P, Batelli R, Ottaviani F et al (2009) Voice disorders and posturography: variables to define the success of rehabilitative treatment. J Voice 23(1):71–75. https://doi.org/10.1016/j.jvoice.2007.06.002

    Article  Google Scholar 

  16. Raez MB, Hussain MS, Mohd-Yasin F (2006) Techniques of EMG signal analysis: detection, processing, classification and applications. Biol Proced Online 8:11–35. https://doi.org/10.1251/bpo115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Liparulo L, Zhang Z, Panella M, Gu X, Fang Q (2017) A novel fuzzy approach for automatic Brunnstrom stage classification using surface electromyography. Med Biol Eng Comput 55(8):1367–1378. https://doi.org/10.1007/s11517-016-1597-3

    Article  PubMed  Google Scholar 

  18. Weber KP, Aw ST, Todd MJ, McGarvie LA, Curthoys IS, Halmagyi GM (2009) Horizontal head impulse test detects gentamicin vestibulotoxicity. Neurology. 72(16):1417–1424. https://doi.org/10.1212/WNL.0b013e3181a18652

    Article  CAS  PubMed  Google Scholar 

  19. Halmagyi GM, Chen L, MacDougall HG, Weber KP, McGarvie LA, Curthoys IS (2017) The video head impulse test. Front Neurol 8:258. https://doi.org/10.3389/fneur.2017.00258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Strupp M, Brandt T (2009) Vestibular neuritis. Semin Neurol 29(5):509–519. https://doi.org/10.1055/s-0029-1241040

    Article  PubMed  Google Scholar 

  21. Alessandrini M, Micarelli A, Chiaravalloti A, Candidi M, Bruno E, Di Pietro B et al (2014) Cerebellar metabolic involvement and its correlations with clinical parameters in vestibular neuritis. J Neurol 261(10):1976–1985. https://doi.org/10.1007/s00415-014-7449-x

    Article  PubMed  Google Scholar 

  22. Jeong SH, Kim HJ, Kim JS (2013) Vestibular neuritis. Semin Neurol 33(3):185–194. https://doi.org/10.1055/s-0033-1354598

    Article  PubMed  Google Scholar 

  23. Alessandrini M, Pagani M, Napolitano B, Micarelli A, Candidi M, Bruno E et al (2013) Early and phasic cortical metabolic changes in vestibular neuritis onset. PLoS One 8(3):e57596. https://doi.org/10.1371/journal.pone.0057596

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Fishman JM, Burgess C, Waddell A (2011) Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis). Cochrane Database Syst Rev 5:Cd008607. https://doi.org/10.1002/14651858.CD008607.pub2

    Article  Google Scholar 

  25. Schneider E, Villgrattner T, Vockeroth J, Bartl K, Kohlbecher S, Bardins S et al (2009) EyeSeeCam: an eye movement-driven head camera for the examination of natural visual exploration. Ann N Y Acad Sci 1164:461–467. https://doi.org/10.1111/j.1749-6632.2009.03858.x

    Article  PubMed  Google Scholar 

  26. Blodow A, Pannasch S, Walther LE (2013) Detection of isolated covert saccades with the video head impulse test in peripheral vestibular disorders. Auris Nasus Larynx 40(4):348–351. https://doi.org/10.1016/j.anl.2012.11.002

    Article  PubMed  Google Scholar 

  27. Micarelli A, Liguori C, Viziano A, Izzi F, Placidi F, Alessandrini M (2017) Integrating postural and vestibular dimensions to depict impairment in moderate-to-severe obstructive sleep apnea syndrome patients. J Sleep Res 26:487–494. https://doi.org/10.1111/jsr.12516

    Article  Google Scholar 

  28. Yang CJ, Cha EH, Park JW, Kang BC, Yoo MH, Kang WS, Ahn JH, Chung JW, Park HJ (2018) Diagnostic value of gains and corrective saccades in video head impulse test in vestibular neuritis. In: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, pp 347–353. https://doi.org/10.1177/0194599818768218

    Chapter  Google Scholar 

  29. Bartolomeo M, Biboulet R, Pierre G, Mondain M, Uziel A, Venail F (2014) Value of the video head impulse test in assessing vestibular deficits following vestibular neuritis. Eur Arch Otorhinolaryngol 271(4):681–688. https://doi.org/10.1007/s00405-013-2451-y

    Article  PubMed  Google Scholar 

  30. McCaslin DL, Jacobson GP, Bennett ML, Gruenwald JM, Green AP (2014) Predictive properties of the video head impulse test: measures of caloric symmetry and self-report dizziness handicap. Ear Hear 35(5):e185–e191. https://doi.org/10.1097/aud.0000000000000047

    Article  PubMed  Google Scholar 

  31. Zellhuber S, Mahringer A, Rambold HA (2014) Relation of video-head-impulse test and caloric irrigation: a study on the recovery in unilateral vestibular neuritis. Eur Arch Otorhinolaryngol 271(9):2375–2383. https://doi.org/10.1007/s00405-013-2723-6

    Article  PubMed  Google Scholar 

  32. Macdougall HG, McGarvie LA, Halmagyi GM, Curthoys IS, Weber KP (2013) The video head impulse test (vHIT) detects vertical semicircular canal dysfunction. PLoS One 8(4):e61488. https://doi.org/10.1371/journal.pone.0061488

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. McGarvie LA, MacDougall HG, Halmagyi GM, Burgess AM, Weber KP, Curthoys IS (2015) The video head impulse test (vHIT) of semicircular canal function—age-dependent normative values of VOR gain in healthy subjects. Front Neurol 6:154. https://doi.org/10.3389/fneur.2015.00154

    Article  PubMed  PubMed Central  Google Scholar 

  34. Micarelli A, Viziano A, Micarelli E, Genovesi G, Bruno E, Alessandrini M (2016) Deranged dimensionality of vestibular re-weighting in multiple chemical sensitivity. Appl Sci (Switzerland) 6(11). https://doi.org/10.3390/app6110330

  35. Mantokoudis G, Saber Tehrani AS, Kattah JC, Eibenberger K, Guede CI, Zee DS, Newman-Toker DE (2015) Quantifying the vestibulo-ocular reflex with video-oculography: nature and frequency of artifacts. Audiol Neurootol 20(1):39–50. https://doi.org/10.1159/000362780

    Article  PubMed  Google Scholar 

  36. Alessandrini M, D’Erme G, Bruno E, Napolitano B, Magrini A (2003) Vestibular compensation: analysis of postural re-arrangement as a control index for unilateral vestibular deficit. Neuroreport. 14(7):1075–1079. https://doi.org/10.1097/01.wnr.0000070827.57864.49

    Article  PubMed  Google Scholar 

  37. Yoneda S, Tokumasu K (1986) Frequency analysis of body sway in the upright posture. Statistical study in cases of peripheral vestibular disease. Acta Otolaryngol 102(1–2):87–92

    Article  CAS  Google Scholar 

  38. Park SH, Park JO (1998) Simultaneous optimization of multiple responses using a weighted desirability function. In: Abraham B (ed) Quality improvement through statistical methods. Birkhäuser Boston, Boston, MA, pp 299–311

    Chapter  Google Scholar 

  39. Weber KP, Aw ST, Todd MJ, McGarvie LA, Curthoys IS, Halmagyi GM (2008) Head impulse test in unilateral vestibular loss: vestibulo-ocular reflex and catch-up saccades. Neurology. 70(6):454–463. https://doi.org/10.1212/01.wnl.0000299117.48935.2e

    Article  CAS  PubMed  Google Scholar 

  40. Newman-Toker DE, Saber Tehrani AS, Mantokoudis G, Pula JH, Guede CI, Kerber KA, Blitz A, Ying SH, Hsieh YH, Rothman RE, Hanley DF, Zee DS, Kattah JC (2013) Quantitative video-oculography to help diagnose stroke in acute vertigo and dizziness: toward an ECG for the eyes. Stroke. 44(4):1158–1161. https://doi.org/10.1161/strokeaha.111.000033

    Article  PubMed  Google Scholar 

  41. Toupet M, Van Nechel C, Bozorg Grayeli A (2014) Influence of body laterality on recovery from subjective visual vertical tilt after vestibular neuritis. Audiol Neurootol 19(4):248–255. https://doi.org/10.1159/000360266

    Article  PubMed  Google Scholar 

  42. Hong SK, Kim JH, Kim HJ, Lee HJ (2014) Changes in the gray matter volume during compensation after vestibular neuritis: a longitudinal VBM study. Restor Neurol Neurosci 32(5):663–673. https://doi.org/10.3233/rnn-140405

    Article  PubMed  Google Scholar 

  43. Patel M, Arshad Q, Roberts RE, Ahmad H, Bronstein AM (2016) Chronic symptoms after vestibular neuritis and the high-velocity vestibulo-ocular reflex. Otol Neurotol 37(2):179–184. https://doi.org/10.1097/mao.0000000000000949

    Article  PubMed  PubMed Central  Google Scholar 

  44. Buki B, Hanschek M, Junger H (2017) Vestibular neuritis: involvement and long-term recovery of individual semicircular canals. Auris Nasus Larynx 44(3):288–293. https://doi.org/10.1016/j.anl.2016.07.020

    Article  PubMed  Google Scholar 

  45. Cousins S, Cutfield NJ, Kaski D, Palla A, Seemungal BM, Golding JF et al (2014) Visual dependency and dizziness after vestibular neuritis. PLoS One 9(9):e105426. https://doi.org/10.1371/journal.pone.0105426

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Godemann F, Siefert K, Hantschke-Bruggemann M, Neu P, Seidl R, Strohle A (2005) What accounts for vertigo one year after neuritis vestibularis - anxiety or a dysfunctional vestibular organ? J Psychiatr Res 39(5):529–534. https://doi.org/10.1016/j.jpsychires.2004.12.006

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier, 1; E sud Tower, 00133, Rome, Italy

    Alessandro Micarelli, Andrea Viziano & Marco Alessandrini

  2. ITER Center for Balance and Rehabilitation Research, Rome, Italy

    Alessandro Micarelli

  3. Department of Information Engineering, Electronics and Telecommunications, University of Rome “La Sapienza”, Rome, Italy

    Massimo Panella

  4. Department of Biology, University of Rome Tor Vergata, Rome, Italy

    Elisa Micarelli

Authors
  1. Alessandro Micarelli
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. Andrea Viziano
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. Massimo Panella
    View author publications

    You can also search for this author inPubMed Google Scholar

  4. Elisa Micarelli
    View author publications

    You can also search for this author inPubMed Google Scholar

  5. Marco Alessandrini
    View author publications

    You can also search for this author inPubMed Google Scholar

Contributions

Study concept and design: AM, MA, AV, MP, and EM. Acquisition of data: AM, MA, and AV. Analysis or interpretation of data: AM, EM, MP, MA, and AV. Drafting/revising the manuscript: AM, MA, AV, EM, and MP. Critical revision of the manuscript for important intellectual content: MA, AM, AV, MP, and EM.

Corresponding author

Correspondence to Marco Alessandrini.

Ethics declarations

The study adhered to the principles of the Declaration of Helsinki, and all the participants provided written informed consent after receiving a detailed explanation of the study, which was approved by the Institutional Ethical Committee of the University of Rome “Tor Vergata” (n.5160/2017).

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

(DOCX 24 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Micarelli, A., Viziano, A., Panella, M. et al. Power spectra prognostic aspects of impulsive eye movement traces in superior vestibular neuritis. Med Biol Eng Comput 57, 1617–1627 (2019). https://doi.org/10.1007/s11517-019-01982-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11517-019-01982-3

Keywords