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Ventricle shape analysis using modified WKS for atrophy detection

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Abstract

Brain ventricle is one of the biomarkers for detecting neurological disorders. Studying the shape of the ventricles will aid in the diagnosis process of atrophy and other CSF-related neurological disorders, as ventricles are filled with CSF. This paper introduces a spectral analysis algorithm based on wave kernel signature. This shape signature was used for studying the shape of segmented ventricles from the brain images. Based on the shape signature, the study groups were classified as normal subjects and atrophy subjects. The proposed algorithm is simple, effective, automated, and less time consuming. The proposed method performed better than the other methods heat kernel signature, scale invariant heat kernel signature, wave kernel signature, and spectral graph wavelet signature, which were used for validation purpose, by producing 94–95% classification accuracy by classifying normal and atrophy subjects correctly for CT, MR, and OASIS datasets.

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Authors and Affiliations

  1. School of Medical Science and Technology, IIT Kharagpur, Kharagpur, India

    Jayaraman Thirumagal & Manjunatha Mahadevappa

  2. EKO CT & MRI Scan Centre, Medical College, Calcutta, India

    Anup Sadhu

  3. Radiologist, EKO-CT & MRI Scan Center, Calcutta Medical College and Hospital, Kolkata, India

    Pranab Kumar Dutta

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  1. Jayaraman Thirumagal
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  2. Manjunatha Mahadevappa
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  3. Anup Sadhu
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  4. Pranab Kumar Dutta
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Correspondence to Manjunatha Mahadevappa.

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Thirumagal, J., Mahadevappa, M., Sadhu, A. et al. Ventricle shape analysis using modified WKS for atrophy detection. Med Biol Eng Comput 59, 1485–1493 (2021). https://doi.org/10.1007/s11517-021-02377-z

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  • DOI: https://doi.org/10.1007/s11517-021-02377-z

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