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Layered mechanical and electrical properties of porcine articular cartilage

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Abstract

The complex structure and composition of articular cartilage make its performance show depth-dependent characteristics, but its related parameters are not complete at present. In this study, porcine articular cartilage was divided into three zones along the thickness direction, and the cartilage tissue in each zone was tested for electrical impedance, compression relaxation, and permeability to obtain their mechanical and electrical impedance parameters. The results showed that there were significant differences in mechanical and electrical properties of cartilage tissue in different zones in which resistivity, elastic modulus, relaxation time, and final relaxation rate increased gradually from superficial zone to deep zone along the direction of cartilage thickness while the permeability decreased gradually. Bioimpedance analysis can capture the phenomenon of very slight histological changes, which is expected to provide information for predicting cartilage degeneration, but the electrical impedance parameters of cartilage are still very lacking. These data are expected to provide reference for the treatment of clinical osteoarthritis and the research of cartilage repair materials.

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Funding

This work was supported by the National Natural Science Foundation of China (Nos. 11972242, 11632013), China Postdoctoral Science Foundation (2020M680913), and Shanxi Province Huajin Orthopedic Public Welfare Foundation.

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Authors and Affiliations

  1. College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China

    Yuqin Sun, Hao Dong, Yan Wang, Yang Yan, Jianhao Yu, Xiaogang Wu, Yanqin Wang & Weiyi Chen

  2. Huajin Orthopaedic Hospital, Taiyuan, 030024, China

    Kai Zhang

  3. College of Physical Education, Taiyuan University of Technology, Taiyuan, 030024, China

    Meizhen Zhang

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  1. Yuqin Sun
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Correspondence to Xiaogang Wu or Weiyi Chen.

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Sun, Y., Zhang, K., Dong, H. et al. Layered mechanical and electrical properties of porcine articular cartilage. Med Biol Eng Comput 60, 3019–3028 (2022). https://doi.org/10.1007/s11517-022-02653-6

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