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Computational assessment of growth of connective tissues around textured hip stem subjected to daily activities after THA

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Abstract

Longer-term stability of uncemented femoral stem depends on ossification at bone-implant interface. Although attempts have been made to assess the amount of bone growth using finite element (FE) analysis in combination with a mechanoregulatory algorithm, there has been little research on tissue differentiation patterns on hip stems with proximal macro-textures. The primary goal of this investigation is to qualitatively compare the formation of connective tissues around a femoral implant with/without macro-textures on its proximal surfaces. This study also predicts formation of different tissue phenotypes and their spatio-temporal distribution around a macro-textured femoral stem under routine activities. Results from the study show that non-textured implants (80 to 94%) encourage fibroplasia compared to that in textured implants (71 to 85.38%) under similar routine activity, which might trigger aseptic loosening of implant. Formation of bone was more on medio-lateral sides and towards proximal regions of Gruen zones 2 and 6, which was found to be in line with clinical observations. Fibroplasia was higher under stair climbing (85 to 91%) compared to that under normal walking (71 to 85.38%). This study suggests that stair climbing, although falls under recommended activity, might be detrimental to patient compared to normal walking in the initial rehabilitation period.

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Acknowledgements

The authors would like to acknowledge Agartala Government Medical College, Agartala, India for providing with the CT scan data set. The authors would also like to acknowledge the computational facilities available at the Composite Structures and Fracture Mechanics Laboratory, Department of Mechanical Engineering, Indian Institute of Technology Guwahati, India, which has helped to carry out the research study. The study was partially funded by SPARC, MHRD, Government of India (Project ID: SPARC/P705).

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Authors and Affiliations

  1. Composite Structures and Fracture Mechanics Laboratory, Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati, 781 039, Assam, India

    Rajdeep Ghosh, Ankan Hazra & Debabrata Chakraborty

  2. Biomechanics and Simulations Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, 781 039, Assam, India

    Souptick Chanda

  3. Mehta Family School of Data Science and Artificial Intelligence, Indian Institute of Technology Guwahati, Guwahati, 781 039, Assam, India

    Souptick Chanda

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Ghosh, R., Hazra, A., Chanda, S. et al. Computational assessment of growth of connective tissues around textured hip stem subjected to daily activities after THA. Med Biol Eng Comput 61, 525–540 (2023). https://doi.org/10.1007/s11517-022-02729-3

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