Abstract
Image registration of magnetic resonance imaging (MRI) pre- and post-therapy is an important part of evaluating the effect of therapy in tumor patients. The accuracy of evaluation results heavily relies on the alignment of the MRI image after registration. Although recent advancements have been made in medical image registration, applying these methods to MRI registration pre- and post-therapy remains challenging. Existing methods typically utilize single-view data for registration. However, when applied to MRI data where some slices are clear while others are blurred, these methods can be misled by erroneous spatial information in the blurred regions, leading to poor registration outcomes. To mitigate the interference caused by erroneous spatial information in single-view data, this paper proposes a multi-stream fusion-assisted registration network that incorporates different-view MRIs of the same patient at the same site. Additionally, a cross-attention guided fusion module is designed within the network to effectively utilize accurate spatial information from multi-view data. The proposed approach was evaluated on clinical data, and the experimental results demonstrated that incorporating multiple view data as auxiliary information significantly enhances the accuracy of MRI image registration before and after radiotherapy.
Graphical abstract
Similar content being viewed by others
References
Thirion J (1998) Image matching as a diffusion process: an analogy with Maxwell’s demons. Medical Image Anal 2(3):243–260. https://doi.org/10.1016/S1361-8415(98)80022-4
Klein S, Staring M, Pluim JPW (2007) Evaluation of optimization methods for nonrigid medical image registration using mutual information and b-splines. IEEE Trans Image Process 16(12):2879–2890. https://doi.org/10.1109/TIP.2007.909412
Klein S, Staring M, Murphy K, Viergever MA, Pluim JPW (2010) elastix: a toolbox for intensity-based medical image registration. IEEE Trans Med Imaging 29(1):196–205
Beg MF, Miller MI, Trouvé A, Younes L (2005) Computing large deformation metric mappings via geodesic flows of diffeomorphisms. Int J Comput Vis 61(2):139–157. https://doi.org/10.1023/B:VISI.0000043755.93987.aa
Avants BB, Tustison NJ, Song G, Cook PA, Klein A, Gee JC (2011) A reproducible evaluation of ants similarity metric performance in brain image registration. Neuroimage 54(3):2033–2044. https://doi.org/10.1016/j.neuroimage.2010.09.025
Vercauteren T, Pennec X, Perchant A, Ayache N (2009) Diffeomorphic demons: efficient non-parametric image registration. Neuroimage 45(1):S61–S72. https://doi.org/10.1016/j.neuroimage.2008.10.040
Lorenzi M, Ayache N, Frisoni GB, Pennec X (2013) LCC-demons: a robust and accurate symmetric diffeomorphic registration algorithm. Neuroimage 81:470–483. https://doi.org/10.1016/j.neuroimage.2013.04.114
Yang T, Bai X, Cui X, Gong Y, Li L (2023) DAU-net: an unsupervised 3d brain MRI registration model with dual-attention mechanism. Int J Imaging Syst Technol 33(1):217–229. https://doi.org/10.1002/ima.22801
Jaderberg M, Simonyan K, Zisserman A, Kavukcuoglu K (2015) Spatial transformer networks. CoRR abs/1506.02025. http://arxiv.org/abs/1506.02025
Balakrishnan G, Zhao A, Sabuncu MR, Guttag JV, Dalca AV (2018a) An unsupervised learning model for deformable medical image registration. In: 2018 IEEE Conference on computer vision and pattern recognition, CVPR 2018, Salt Lake City, UT, USA, June 18-22, 2018, computer vision foundation / IEEE computer society, pp 9252–9260
Kuang D, Schmah T (2019) FAIM - A convnet method for unsupervised 3d medical image registration. In: Suk H, Liu M, Yan P, Lian C (eds) Machine learning in medical imaging - 10th international workshop, MLMI 2019, held in conjunction with MICCAI 2019, Shenzhen, China, October 13, 2019, proceedings, Springer, Lecture Notes in Computer Science, vol 11861, pp 646–654. https://doi.org/10.1007/978-3-030-32692-0_74
de Vos BD, Berendsen FF, Viergever MA, Staring M, Isgum I (2017) End-to-end unsupervised deformable image registration with a convolutional neural network. CoRR abs/1704.06065. http://arxiv.org/abs/1704.06065
Zhang J (2018) Inverse-consistent deep networks for unsupervised deformable image registration. CoRR abs/1809.03443. http://arxiv.org/abs/1809.03443
Mok TCW, Chung ACS (2020a) Fast symmetric diffeomorphic image registration with convolutional neural networks. CoRR abs/2003.09514. https://arxiv.org/abs/2003.09514
Han R, Jones CK, Lee J, Wu P, Vagdargi P, Uneri A, Helm PA, Luciano M, Anderson WS, Siewerdsen JH (2022) Deformable MR-CT image registration using an unsupervised, dual-channel network for neurosurgical guidance. Medical Image Anal 75:102292. https://doi.org/10.1016/j.media.2021.102292
Fechter T, Baltas D (2020) One-shot learning for deformable medical image registration and periodic motion tracking. IEEE Trans Medical Imaging 39(7):2506–2517. https://doi.org/10.1109/TMI.2020.2972616
Mok TCW, Chung ACS (2021) Conditional deformable image registration with convolutional neural network. In: de Bruijne M, Cattin PC, Cotin S, Padoy N, Speidel S, Zheng Y, Essert C (eds) Medical image computing and computer assisted intervention - MICCAI 2021 - 24th international conference, Strasbourg, France, September 27 - October 1, 2021, Proceedings, Part IV, Springer, Lecture Notes in Computer Science, vol 12904, pp 35–45. https://doi.org/10.1007/978-3-030-87202-1_4
Hering A, van Ginneken B, Heldmann S (2019) mlvirnet: multilevel variational image registration network. In: Shen D, Liu T, Peters TM, Staib LH, Essert C, Zhou S, Yap P, Khan AR (eds) Medical image computing and computer assisted intervention - MICCAI 2019 - 22nd international conference, Shenzhen, China, October 13-17, 2019, Proceedings, Part VI, Springer, Lecture Notes in Computer Science, vol 11769, pp 257–265. https://doi.org/10.1007/978-3-030-32226-7_29
He Z, He Y, Cao W (2023) Deformable image registration with attention-guided fusion of multi-scale deformation fields. Appl Intell 53(3):2936–2950. https://doi.org/10.1007/s10489-022-03659-1
Mok TCW, Chung ACS (2022) Unsupervised deformable image registration with absent correspondences in pre-operative and post-recurrence brain tumor MRI scans. In: Wang L, Dou Q, Fletcher PT, Speidel S, Li S (eds) Medical image computing and computer assisted intervention - MICCAI 2022 - 25th International Conference, Singapore, September 18-22, 2022, proceedings, Part VI, Springer, Lecture Notes in Computer Science, vol 13436, pp 25–35. https://doi.org/10.1007/978-3-031-16446-0_3
Hu X, Kang M, Huang W, Scott MR, Wiest R, Reyes M (2019) Dual-stream pyramid registration network. CoRR abs/1909.11966. http://arxiv.org/abs/1909.11966
Mok TCW, Chung ACS (2020b) Large deformation diffeomorphic image registration with Laplacian pyramid networks. CoRR abs/2006.16148. https://arxiv.org/abs/2006.16148
Li C, Zhou Y, Li Y, Yang S (2021) A coarse-to-fine registration method for three-dimensional MR images. Medical Biol Eng Comput 59(2):457–469. https://doi.org/10.1007/s11517-021-02317-x
Ronneberger O, Fischer P, Brox T (2015) U-net: convolutional networks for biomedical image segmentation. CoRR abs/1505.04597
de Vos BD, Berendsen FF, Viergever MA, Sokooti H, Staring M, Isgum I (2018) A deep learning framework for unsupervised affine and deformable image registration. CoRR abs/1809.06130. http://arxiv.org/abs/1809.06130
Balakrishnan G, Zhao A, Sabuncu MR, Guttag JV, Dalca AV (2018b) An unsupervised learning model for deformable medical image registration. CoRR abs/1802.02604. http://arxiv.org/abs/1802.02604
Kim B, Kim J, Lee J, Kim DH, Park SH, Ye JC (2019) Unsupervised deformable image registration using cycle-consistent CNN. CoRR abs/1907.01319. http://arxiv.org/abs/1907.01319
Berthilsson R (1998) Affine correlation. In: Jain AK, Venkatesh S, Lovell BC (eds) Fourteenth International Conference on Pattern Recognition, ICPR 1998, Brisbane, Australia, 16-20 August, 1998, IEEE Computer Society, pp 1458–1460. https://doi.org/10.1109/ICPR.1998.711979
Shu Y, Wang H, Xiao B, Bi X, Li W (2021) Medical image registration based on uncoupled learning and accumulative enhancement. In: de Bruijne M, Cattin PC, Cotin S, Padoy N, Speidel S, Zheng Y, Essert C (eds) Medical Image Computing and Computer Assisted Intervention - MICCAI 2021 - 24th International Conference, Strasbourg, France, September 27 - October 1, 2021, Proceedings, Part IV, Springer, Lecture Notes in Computer Science, vol 12904, pp 3–13. https://doi.org/10.1007/978-3-030-87202-1_1
Funding
This work was supported by Natural Science Foundation of China (No.82272617) and Pearl River S &T Nova Program of Guangzhou (201710010162).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Liu, Y., Li, X., Li, R. et al. A multi-view assisted registration network for MRI registration pre- and post-therapy. Med Biol Eng Comput 61, 3181–3191 (2023). https://doi.org/10.1007/s11517-023-02949-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11517-023-02949-1