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Intraoperative visualization of cerebral oxygenation using hyperspectral image data: a two-dimensional mapping method

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

Superficial temporal artery (STA)—middle cerebral artery (MCA) bypass is an important technique for cerebrovascular reconstruction. Intraoperative hemodynamic imaging is needed to perform cerebrovascular reconstruction safely and effectively. Optical intrinsic signal (OIS) imaging is commonly used for assessing cerebral hemodynamics in experimental studies, because it can provide high-resolution mapping images. However, OIS is not used clinically due to algorithm, instrumentation and spectral resolution limitations. We tested the feasibility of a hyperspectral camera (HSC) for assessment of cortical hemodynamics with spectral imaging of the cerebral cortex in rats and in vivo humans.

Methods

A hyperspectral camera (HSC) was tested in a rat model of cerebral ischemia (middle cerebral artery occlusion) and during human revascularization surgery (STA–MCA anastomosis). Changes in cortical oxygen saturation were derived from spectral imaging data (400–800 nm) collected by exposing the cortex to Xenon light. Reflected light was sampled using the HSC. The system was then tested intraoperatively during superficial temporal artery to middle cerebral artery anastomosis procedures. Comparison with single-photon emission computed tomography (SPECT) imaging data was done.

Results

During middle cerebral artery occlusion in rats, the HSC technique showed a significant decrease in cortical oxygen saturation in the ischemic hemisphere. In clinical cases, the cortical oxygen saturation was increased after STA–MCA anastomosis, which agreed with the SPECT imaging data.

Conclusion

Continuous collection of imaging spectroscopic data is feasible and may provide reliable quantification of the hemodynamic responses in the brain. The HSC system may be useful for monitoring intraoperative changes in cortical surface hemodynamics during revascularization procedures in humans.

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Acknowledgments

We thank Junji Kishimoto for his valuable assistance with the statistical analyses.

Conflict of interest

The authors declare no conflict of interest in association with this study.

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Authors and Affiliations

  1. Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Megumu Mori, Akira Nakamizo, Yuichiro Kikkawa, Koji Yoshimoto, Masahiro Mizoguchi & Tomio Sasaki

  2. PENTAX Lifecare Division Medical Instrument SBU, HOYA Corporation, 1-1-110 Tsutsujigaoka, Akishima-shi, Tokyo, 196-0012, Japan

    Toru Chiba

  3. Department of Advanced Medicine and Innovative Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Ryuichi Kumashiro & Morimasa Tomikawa

  4. Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Masaharu Murata

  5. Department of Advanced Medical Initiatives, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Tomohiko Akahoshi & Makoto Hashizume

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  1. Megumu Mori
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  2. Toru Chiba
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  3. Akira Nakamizo
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Correspondence to Makoto Hashizume.

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Mori, M., Chiba, T., Nakamizo, A. et al. Intraoperative visualization of cerebral oxygenation using hyperspectral image data: a two-dimensional mapping method. Int J CARS 9, 1059–1072 (2014). https://doi.org/10.1007/s11548-014-0989-9

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  • DOI: https://doi.org/10.1007/s11548-014-0989-9

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