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A study of MRI-based radiomics biomarkers for sacroiliitis and spondyloarthritis

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the performance of texture-based biomarkers by radiomic analysis using magnetic resonance imaging (MRI) of patients with sacroiliitis secondary to spondyloarthritis (SpA). Relevance: The determination of sacroiliac joints inflammatory activity supports the drug management in these diseases.

Methods

Sacroiliac joints (SIJ) MRI examinations of 47 patients were evaluated. Thirty-seven patients had SpA diagnoses (27 axial SpA and ten peripheral SpA) which was established previously after clinical and laboratory follow-up. To perform the analysis, the SIJ MRI was first segmented and warped. Second, radiomics biomarkers were extracted from the warped MRI images for associative analysis with sacroiliitis and the SpA subtypes. Finally, statistical and machine learning methods were applied to assess the associations of the radiomics texture-based biomarkers with clinical outcomes.

Results

All diagnostic performances obtained with individual or combined biomarkers reached areas under the receiver operating characteristic curves ≥ 0.80 regarding SpA related sacroiliitis and and SpA subtypes classification. Radiomics texture-based analysis showed significant differences between the positive and negative SpA groups and differentiated the axial and peripheral subtypes (P < 0.001). In addition, the radiomics analysis was also able to correctly identify the disease even in the absence of active inflammation.

Conclusion

We concluded that the application of the radiomic approach constitutes a potential noninvasive tool to aid the diagnosis of sacroiliitis and for SpA subclassifications based on MRI of sacroiliac joints.

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Funding

This study was funded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) [Grants Nos. 2016/17078-0, 2014/50889-7].

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Authors and Affiliations

  1. Ribeirão Preto Medical School, University of São Paulo, Av. dos Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil

    Ariane Priscilla Magalhães Tenório, Matheus Calil Faleiros, José Raniery Ferreira Junior, Vitor Faeda Dalto, Rodrigo Luppino Assad, Paulo Louzada-Junior, Marcello Henrique Nogueira-Barbosa & Paulo Mazzoncini de Azevedo-Marques

  2. Massachusetts General Hospital, Harvard Medical School, 25 New Chardon St, Boston, MA, 02114, USA

    Hiroyuki Yoshida

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  1. Ariane Priscilla Magalhães Tenório
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  2. Matheus Calil Faleiros
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  9. Paulo Mazzoncini de Azevedo-Marques
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Correspondence to Ariane Priscilla Magalhães Tenório.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Comitê de Ética em Pesquisa do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Reference No. 2.356.447).

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Tenório, A.P.M., Faleiros, M.C., Junior, J.R.F. et al. A study of MRI-based radiomics biomarkers for sacroiliitis and spondyloarthritis. Int J CARS 15, 1737–1748 (2020). https://doi.org/10.1007/s11548-020-02219-7

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  • DOI: https://doi.org/10.1007/s11548-020-02219-7

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