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Deep convolution feature aggregation: an application to diabetic retinopathy severity level prediction

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Abstract

Diabetic retinopathy (DR) is one of the main causes of loss of vision and blindness in humans across the world. DR is usually found in patients suffering from diabetes for a long period. Automation of DR diagnosis rescues many people from going blind by identifying the disease at the early stages. In this work, we introduce a robust model for DR severity level prediction by leveraging features extracted from pre-trained models to represent DR images. The activation filter values from multiple convolution blocks of VGG-16 are extracted and aggregated using pooling and fusion methods. The aggregation module produces a compact, informative, and discriminative representation of the retinal images by removing noisy and redundant features using pooling and fusion approaches. These feature representations are fed to the proposed DNN architecture to identify the severity level of DR. On the benchmark Kaggle APTOS 2019 contest dataset, our proposed method sets a new state-of-the-art result with an accuracy of 84.31% and an AUC 97. Experimental studies reveal that the proposed model exhibits superior performance compared with the existing models, especially in the case of severe and proliferate stage DR images.

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References

  1. Aptos 2019. https://www.kaggle.com/c/aptos2019-blindness-detection. Accessed 30 Dec 2019 (2019)

  2. Akram, M.U., Khalid, S., Khan, S.A.: Identification and classification of microaneurysms for early detection of diabetic retinopathy. Pattern Recognit. 46(1), 107–116 (2013)

    Article  Google Scholar 

  3. Bodapati, J.D., Veeranjaneyulu, N.: Feature extraction and classification using deep convolutional neural networks. J. Cyber Secur. Mobil. 8(2), 261–276 (2019)

    Article  Google Scholar 

  4. Bodapati, J.D., Veeranjaneyulu, N., Shareef, S.N., Hakak, S., Bilal, M., Maddikunta, P.K.R., Jo, O.: Blended multi-modal deep convnet features for diabetic retinopathy severity prediction. Electronics 9(6), 914 (2020)

    Article  Google Scholar 

  5. Bodapati, J.D., Naralasetti, V.: Role of deep neural features vs hand crafted features for hand written digit recognition. Int. J. Recent Technol. Eng. 7, 147–152 (2019)

    Google Scholar 

  6. Bodapati, J.D., Naralasetti, V.: Facial emotion recognition using deep CNN based features. Int. J. Innov. Technol. Explor. Eng. 8, 1928–1931 (2019)

    Google Scholar 

  7. Casanova, R., Saldana, S., Chew, E.Y., Danis, R.P., Greven, C.M., Ambrosius, W.T.: Application of random forests methods to diabetic retinopathy classification analyses. PLoS ONE 9, 6 (2014)

    Google Scholar 

  8. Cheung, N., Rogers, S.L., Donaghue, K.C., Jenkins, A.J., Tikellis, G., Wong, T.Y.: Retinal arteriolar dilation predicts retinopathy in adolescents with type 1 diabetes. Diabetes Care 31(9), 1842–1846 (2008)

    Article  Google Scholar 

  9. Flaxman, S., Bourne, R., Resnikoff, S., Ackland, P., Braithwaite, T., Cicinelli, M., Das, A., Jonas, J., Keeffe, J., Kempen, J., et al.: Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. Lancet Glob. Health. 5(12), e1221-34 (2017)

    Article  Google Scholar 

  10. García, G., Gallardo, J., Mauricio, A., López, J., Del Carpio, C.: Detection of diabetic retinopathy based on a convolutional neural network using retinal fundus images. In: International Conference on Artificial Neural Networks, pp. 635–642. Springer, Berlin (2017)

  11. Gulshan, V., Peng, L., Coram, M., Stumpe, M.C., Wu, D., Narayanaswamy, A., Venugopalan, S., Widner, K., Madams, T., Cuadros, J., et al.: Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA 316(22), 2402–2410 (2016)

    Article  Google Scholar 

  12. Habib, M., Welikala, R., Hoppe, A., Owen, C., Rudnicka, A., Barman, S.: Detection of microaneurysms in retinal images using an ensemble classifier. Inf. Med. Unlocked 9, 44–57 (2017)

    Article  Google Scholar 

  13. Haloi, M., Dandapat, S., Sinha, R.: A gaussian scale space approach for exudates detection, classification and severity prediction. arXiv preprint arXiv:1505.00737 (2015)

  14. Huan, E.-Y., Wen, G.-H.: Multilevel and multiscale feature aggregation in deep networks for facial constitution classification. Comput. Math. Methods Med. 2019, 1–11 (2019)

    Article  Google Scholar 

  15. Jeong, D., Choo, S., Seo, W., Cho, N.I.: Regional deep feature aggregation for image retrieval. In: 2017 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), pp. 1737–1741. IEEE (2017)

  16. Kassani, S.H., Kassani, P.H., Khazaeinezhad, R., Wesolowski, M.J., Schneider, K.A., Deters, R.: Diabetic retinopathy classification using a modified xception architecture. In: 2019 IEEE International Symposium on Signal Processing and Information Technology (ISSPIT), pp. 1–6. IEEE (2017)

  17. Lee, K.-S., Jung, S.-K., Ryu, J.-J., Shin, S.-W., Choi, J.: Evaluation of transfer learning with deep convolutional neural networks for screening osteoporosis in dental panoramic radiographs. J. Clin. Med. 9(2), 392 (2020)

    Article  Google Scholar 

  18. Long, S., Huang, X., Chen, Z., Pardhan, S., Zheng, D.: Automatic detection of hard exudates in color retinal images using dynamic threshold and SVM classification: algorithm development and evaluation. BioMed Res. Int. 2019, 1–13 (2019)

    Article  Google Scholar 

  19. Mansour, R.F.: Deep-learning-based automatic computer-aided diagnosis system for diabetic retinopathy. Biomed. Eng. Lett. 8(1), 41–57 (2018)

    Article  Google Scholar 

  20. Mateen, M., Wen, J., Song, S., Huang, Z., et al.: Fundus image classification using VGG-19 architecture with PCA and SVD. Symmetry 11(1), 1 (2019)

    Article  Google Scholar 

  21. Mookiah, M.R.K., Acharya, U.R., Martis, R.J., Chua, C.K., Lim, C.M., Ng, E., Laude, A.: Evolutionary algorithm based classifier parameter tuning for automatic diabetic retinopathy grading: a hybrid feature extraction approach. Knowl. Based Syst. 39, 9–22 (2013)

    Article  Google Scholar 

  22. Noushin, E., Pourreza, M., Masoudi, K., Ghiasi Shirazi, E.: Microaneurysm detection in fundus images using a two step convolution neural network. Biomed. Eng. Online 18(1), 67 (2019)

    Article  Google Scholar 

  23. Ozkan, S., Bozdagi Akar, G.: Relaxed spatio-temporal deep feature aggregation for real-fake expression prediction. In: Proceedings of the IEEE International Conference on Computer Vision Workshops, pp. 3094–3100 (2017)

  24. Qureshi, I., Ma, J., Abbas, Q.: Recent development on detection methods for the diagnosis of diabetic retinopathy. Symmetry 11(6), 749 (2019)

    Article  Google Scholar 

  25. Roychowdhury, S., Koozekanani, D.D., Parhi, K.K.: Dream: diabetic retinopathy analysis using machine learning. IEEE J. Biomed. Health Inform. 18(5), 1717–1728 (2013)

    Article  Google Scholar 

  26. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. In: ICLR (2015)

  27. Srivastava, R., Duan, L., Wong, D.W., Liu, J., Wong, T.Y.: Detecting retinal microaneurysms and hemorrhages with robustness to the presence of blood vessels. Comput. Methods Programs Biomed. 138, 83–91 (2017)

    Article  Google Scholar 

  28. Verma, K., Deep, P., Ramakrishnan, A.: Detection and classification of diabetic retinopathy using retinal images. In: 2011 Annual IEEE India Conference, pp. 1–6. IEEE (2011)

  29. Wang, Q., Lai, J., Xu, K., Liu, W., Lei, L.: Beauty product image retrieval based on multi-feature fusion and feature aggregation. In: Proceedings of the 26th ACM International Conference on Multimedia, pp. 2063–2067 (2018)

  30. Williams, R., Airey, M., Baxter, H., Forrester, J.-M., Kennedy-Martin, T., Girach, A.: Epidemiology of diabetic retinopathy and macular oedema: a systematic review. Eye 18(10), 963–983 (2004)

    Article  Google Scholar 

  31. Wu, L., Fernandez-Loaiza, P., Sauma, J., Hernandez-Bogantes, E., Masis, M.: Classification of diabetic retinopathy and diabetic macular edema. World J. Diabetes 4(6), 290 (2013)

    Article  Google Scholar 

  32. Yu, F., Wang, D., Shelhamer, E., Darrell, T.: Deep layer aggregation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2403–2412 (2018)

  33. Zeng, X., Chen, H., Luo, Y., Ye, W.: Automated diabetic retinopathy detection based on binocular siamese-like convolutional neural network. IEEE Access 7, 30744–30753 (2019)

    Article  Google Scholar 

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Correspondence to Veeranjaneyulu Naralasetti.

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Bodapati, J.D., Shaik, N.S. & Naralasetti, V. Deep convolution feature aggregation: an application to diabetic retinopathy severity level prediction. SIViP 15, 923–930 (2021). https://doi.org/10.1007/s11760-020-01816-y

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