Skip to main content
Log in

Automatic detection of pulmonary nodules in CT images based on 3D Res-I network

  • Original Article
  • Published:
The Visual Computer Aims and scope Submit manuscript

Abstract

It is difficult for the existing detection methods of the pulmonary nodules to take into account the global and local features simultaneously. It will lead to over-fitting and lower sensitivity since the extracted features of 3D pulmonary nodules is too complex. To solve these problems, a model based an improved 3D residual structure (3D Res-I) was proposed to detect pulmonary nodules. In the model, the basic residual structure is improved by using rectangular convolution kernel, grouping convolution and pre-activation. Rectangular convolution kernel expands the receptive filed of the convolution, which effectively takes into account the global and local features of the pulmonary nodules. Grouping convolution reduces the computational cost of the model. Pre-activation operation alleviates over-fitting phenomenon. 3D Res-I structure is combined with the improved U-Net network as the feature extraction network of Faster R-CNN. The experimental results on LUNA16 dataset show that the proposed model improves the detection accuracy of pulmonary nodules and reduces the average number of false positives and the size of the generated model.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Qui, S.: Study of algorithms for lung nodule segmentation and detection based on CT images. Xidian University, Xidian (2012)

    Google Scholar 

  2. Tariq, A., Akram, M.U., Javed, M.Y.: Lung nodule detection in CT images using neuro fuzzy classifier. Telkomnika. 11(2), 49–53 (2013)

    Article  Google Scholar 

  3. Luo, X.: Research of detection algorithm of pulmonary nodules based on DICOM sequence. University of Electronic Science and Technology of China, Beijing (2015)

    Google Scholar 

  4. Miao, F.: Detection of pulmonary nodules based on correlation matrix and genetic algorithm. University of Science and Technology of China, Beijing (2018)

    Google Scholar 

  5. Keshani, M., Azimifar, Z., Tajeripour, F., Boostani, R.: Lung nodule segmentation and recognition using SVM classifier and active contour modeling: a complete intelligent system. Comput. Biol. Med. 43(4), 287–300 (2013)

    Article  Google Scholar 

  6. Pu, J., Roos, J., Yi, C.A., Napel, S., Rubin, G.D., Paik, D.S.: Adaptive border marching algorithm: automatic lung segmentation on chest CT images. Comput. Med. Imaging Graph. 32(6), 452–462 (2008)

    Article  Google Scholar 

  7. Dai, S., Lu, K., Zhai, R., Dong, J.: Lung segmentation method based on 3D region growing method and improved convex hull algorithm. J. Electron. Inform. Technol. 038(9), 2358–2364 (2016)

    Google Scholar 

  8. Kitasaka, T., Mori, K., Hasegawa, J.I., Toriwaki, J.I.: Automated extraction of aorta and pulmonary artery in mediastinum from 3D chest x-ray CT images without contrast medium. Proc. 4684(2009), 1496–1507 (2002)

    Google Scholar 

  9. Aykac, D., Hoffman, E.A., Mclennan, G., Reinhardt, J.M.: Segmentation and analysis of the human airway tree from three-dimensional X-ray CT images. IEEE Trans. Med. Imaging 22(8), 940–950 (2003)

    Article  Google Scholar 

  10. Chen, X., Tian, Z.: Automatic segmentation of pulmonary parenchyma in thoracic high resolution CT. J. Shanghai Jiaotong Univ. 36(7), 946–948 (2002)

    Google Scholar 

  11. Wu, S., Wang, J.: Pulmonary nodules 3D detection on serial CT scans. In: 2012 Third Global Congress on Intelligent Systems (GCIS). Wuhan China. 257–260 (2012)

  12. Ko, J.P., Naidich, D.P.: Computer-aided diagnosis and the evaluation of lung disease. J. Thorac. Imaging 19(3), 136–155 (2004)

    Article  Google Scholar 

  13. Dehmeshki, J., Amin, H., Valdivieso, M., Ye, X.: Segmentation of pulmonary nodules in thoracic CT scans: a region growing approach. IEEE Trans. Med. Imaging 27(4), 467–480 (2008)

    Article  Google Scholar 

  14. Lassen, B.C., Jacobs, C., Kuhnigk, J.M., Van Ginneken, B., Van Rikxoort, E.M.: Robust semi-automatic segmentation of pulmonary subsolid nodules in chest computed tomography scans. Phys. Med. Biol. 60(3), 1307–1323 (2015)

    Article  Google Scholar 

  15. Li, Q., Li, F., Doi, K.: Computerized detection of lung nodules in thin-section CT images by use of selective enhancement filters and an automated rule-based classifier. Acad. Radiol. 15(2), 165–175 (2008)

    Article  Google Scholar 

  16. Riccardi, A., Petkov, T.S., Ferri, G., Masotti, M., Campanini, R.: Computer-aided detection of lung nodules via 3D fast radial transform, scale space representation, and Zernike MIP classification. Med. Phys. 38(4), 1962–1971 (2011)

    Article  Google Scholar 

  17. Bae, K.T., Kim, J.S., Na, Y.H., Kim, K.G., Kim, J.H.: Pulmonary nodules: Automated detection on CT images with morphologic matching algorithm-preliminary results. Radiology 236(1), 286–293 (2005)

    Article  Google Scholar 

  18. Okumura, T., Miwa, T., Kako, J.I., Yamamoto, S.: Automatic detection of lung cancers in chest CT images by variable N-Quoit filter. In: Pattern recognition, Fourteenth international conference on IEEE. Brisbane. 1671–1673 (1998)

  19. Sivakumar, S., Chandrasekar, C.: Lung nodule detection using fuzzy clustering and support vector machines. Int. J. Eng. Technol. 5(1), 179–185 (2013)

    Google Scholar 

  20. Boroczky, L., Zhao, L., Lee, K.P.: Feature subset selection for improving the performance of false positive reduction in lung nodule CAD. IEEE Trans. Inf Technol. Biomed. 10(3), 504–511 (2006)

    Article  Google Scholar 

  21. Santos, A.M., Filho, A.O., Silva, A.C., Paiva, A.C., Nunes, R.A., Gattass, M.: Automatic detection of small lung nodules in 3D CT data using Gaussian mixture models, Tsallis entropy and SVM. Eng. Appl. Artif. Intell. 36, 27–39 (2014)

    Article  Google Scholar 

  22. Li, Y.: A detection algorithm based on morphology and gray entropy for pulmonary nodules. Beijing Jiaotong University, Beijing (2011)

    Book  Google Scholar 

  23. Murphy, K., Van Ginneken, B., Schilham, A.M.R., Hoop, B.J., Gietema, H.A., Prokop, M.: A large-scale evaluation of automatic pulmonary nodule detection in chest CT using local image features and k-nearest-neighbour classification. Med. Image Anal. 13(5), 757–770 (2009)

    Article  Google Scholar 

  24. Kuanar, S., Athitsos, V., Mahapatra, D., Rao, K. R., Akhtar, Z., Dasgupta, D.: Low dose abdominal CT image reconstruction: an unsupervised learning based approach. In: 2019 IEEE International Conference on Image Processing (ICIP), Taipei, Taiwan. 1351–1355 (2019)

  25. Kuanar, S., Athitsos, V., Pradhan, N., Mishra, A., Rao, K. R.: Cognitive analysis of working memory load from Eeg, by a deep recurrent neural network. In: 2018 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), Calgary, AB. 2576–2580 (2018)

  26. Sharma, S., Mehra, R.: Effect of layer-wise fine-tuning in magnification-dependent classification of breast cancer histopathological images. Vis. Comput. (2019)

  27. Gu, Y., Lu, X., Yang, L., Zhang, B., Yu, D., Zhao, Y., Gao, L., Wu, L., Zhou, Y.: Automatic lung nodule detection using a 3D deep convolutional neural network combined with a multi-scale prediction strategy in chest CTs. Comput. Biol. Med. 103, 220–231 (2018)

    Article  Google Scholar 

  28. Bi, L., Kim, J., Kumar, A., Fulham, M., Feng, D.: Stacked fully convolutional networks with multi-channel learning: application to medical image segmentation. Vis. Comput. 33(6-8), 1061–1071 (2017)

    Article  Google Scholar 

  29. Setio, A.A., Ciompi, F., Litjens, G., Gerke, P., Jacobs, C., Van Riel, S.J., Wille, M.M., Naqibullah, M., Sanchez, C.L., Van Ginneken, B.: Pulmonary nodule detection in CT images: false positive reduction using multi-view convolutional networks. IEEE Trans. Med. Imaging 35(5), 1160–1169 (2016)

    Article  Google Scholar 

  30. Shen, W., Zhou, M., Yang, F., Yang, C.Y., Tian, J.: Multi-scale convolutional neural networks for lung nodule classification. Inf. Process. Med. Imaging. 24, 588–599 (2015)

    Google Scholar 

  31. Alakwaa, W., Nassef, M., Badr, A.: Lung cancer detection and classification with 3D convolutional neural network (3D-CNN). Int. J. Adv. Comput. Sci. Appl. 8(8), 409–417 (2017)

    Google Scholar 

  32. Dou, Q., Chen, H., Jin, Y.M., Lin, H.J., Qin, J., Heng, P.A.: Automated pulmonary nodule detection via 3D ConvNets with online sample filtering and hybrid-loss residual learning. In: International Conference on Medical Image Computing & Computer-assisted Intervention Springer. Cham. 630–638 (2017)

  33. Zhao, P.F., Zhao, J.J., Qiang, Y., Wang, F.Z., Zhao, W.T.: Detection of pulmonary nodules in multi-input convolutional neural networks. Comput. Sci. 45(1), 162–166 (2018)

    Google Scholar 

  34. Yang, J.J., Wang, Q., Xuan, X.H.: Detection model of pulmonary nodules based on deep convolution neural network algorithm. Math. Model. Appl. 12.6.4:1–9+91 (2017)

  35. Zhu, W.T., Liu, C., Fan, W., Xie, X.H.: DeepLung: deep 3D dual path nets for automated pulmonary nodule detection and classification. In: 2018 IEEE Winter Conference on Applications of Computer Vision (WACV). 673–681 (2018)

  36. Ronneberger O, Fischer P, Brox T.: U-net: convolutional networks for biomedical image segmentation. In: The 18th International Conference on Medical Image Computing and Computer Assisted Interventions (MICCAI), Munich. 234–241 (2015)

  37. Ren, S.Q., He, K.M., Girshick, R., Sun, J.: Faster R-CNN: towards real-time object detection with region proposal networks. IEEE Trans. Pattern Anal. Mach. Intell. 39(6), 1137–1149 (2017)

    Article  Google Scholar 

  38. Ioffe, S., Szegedy, C.: Batch Normalization: accelerating deep network training by reducing internal covariate shift. In: 32nd International Conference on Machine learning: ICML 2015. France. 676–685 (2016)

  39. Xavier, G., Antoine B., Yoshua B.: Deep sparse rectifier neural networks. In: JMLR: Workshop and Conference Proceedings. 15:315–323 (2011)

  40. He, K.M., Zhang, X.Y., Ren, S.Q., Sun, J.: Deep residual learning for image recognition. In: 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). Laswegas. 770–778 (2016)

  41. Xie, S.N., Girshick, R., Dollar, P., Tu, Z.W.: Aggregated residual transformations for deep neural networks. In: 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). Hawaii. 5987–5995 (2017)

  42. He, K.M., Zhang, X.Y., Ren, S.Q., Sun, J.: Identity mappings in deep residual networks. In: The 14th European Conference on Computer Vision (ECCV). Amsterdam. 630–645 (2016)

  43. https://luna16.grand-challenge.org/data/. Accessed 16 Aug 2019

  44. Li, D., Vilmun, B.M., Carlsen, J.F., Albrecht-Beste, E., Laurudsen, C.A., Nielsen, M.B., Hansen, K.L.: The performance of deep learning algorithms on automatic pulmonary nodule detection and classification tested on different datasets that are not derived from LIDC-IDRI: a systematic review. Diagnostics (Basel, Switzerland). 9(4), 207–222 (2019)

    Google Scholar 

  45. Zhang, T.: Research on detection and diagnosis methods for pulmonary nodules based on restricted Boltzmann machine. Taiyuan University of Technology, Taiyuan (2018)

    Google Scholar 

  46. Kuanar, S., Rao, K., Mahapatra, D., Bilas, M.: Night time haze and glow removal using deep dilated convolutional network. arXiv preprint arXiv:1902.00855, 2019 (2019)

  47. Kuanar, S., Rao, K., Monalisa, D., Bilas, M.: Adaptive CU mode selection in HEVC intra prediction: a deep learning approach. Circuits Syst. Signal Process. 38, 5081–5102 (2019)

    Article  Google Scholar 

  48. Bakshi, A., Patel, A. K.: A novel error diffusion algorithm for Halftoning Greyscale image using pull based method. In: 2018 International Conference on Communication and Signal Processing (ICCSP), Chennai. 0305–0311 (2018)

Download references

Acknowledgements

This work was supported by the Natural Science Foundation of Hebei Province of China [Grant No. F2017202145].

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lukui Shi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shi, L., Ma, H. & Zhang, J. Automatic detection of pulmonary nodules in CT images based on 3D Res-I network. Vis Comput 37, 1343–1356 (2021). https://doi.org/10.1007/s00371-020-01869-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00371-020-01869-7

Keywords

Navigation