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Physiology-based ERPs in normal and abnormal states

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Abstract

Evoked response potentials (ERPs) and other transients are modeled as impulse responses using physiology-based neural field theory (NFT) of the corticothalamic system of neural activity in the human brain that incorporates synaptic and dendritic dynamics, firing response, axonal propagation, and corticocortical and corticothalamic pathways. The properties of model-predicted ERPs are explored throughout the stability zone of the corticothalamic system, and predicted time series and wavelet spectra are also analyzed. This provides a unified treatment of predicted ERPs for both normal and abnormal states within the brain’s stability zone, including likely parameters to represent abnormal states of reduced arousal.

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Reproduced with permission from Robinson et al. (2002) (color figure online)

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Acknowledgements

We thank R. Townsend for assistance with MATLAB and S. Assadzadeh for helpful discussions. This work was supported by the Australian Research Council Center of Excellence for Integrative Brain Function (ARC Center of Excellence Grant CE140100007), Australian Research Council Laureate Fellowship Grant FL140100025, and Discovery Early Career Research Award DE140101375.

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Authors and Affiliations

  1. School of Physics, The University of Sydney, Sydney, NSW, 2006, Australia

    M S Zobaer, P A Robinson & C C Kerr

  2. Center for Integrative Brain Function, The University of Sydney, Sydney, NSW, 2006, Australia

    M S Zobaer, P A Robinson & C C Kerr

  3. Center for Research Excellence, Neurosleep, 431 Glebe Point Rd, Glebe, NSW, 2037, Australia

    M S Zobaer & P A Robinson

  4. Department of Physics, Bangladesh University of Textiles, Dhaka, 1208, Bangladesh

    M S Zobaer

  5. Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY, USA

    C C Kerr

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  1. M S Zobaer
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Correspondence to M S Zobaer.

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Communicated by J. Leo van Hemmen.

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Zobaer, M.S., Robinson, P.A. & Kerr, C.C. Physiology-based ERPs in normal and abnormal states. Biol Cybern 112, 465–482 (2018). https://doi.org/10.1007/s00422-018-0766-x

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  • DOI: https://doi.org/10.1007/s00422-018-0766-x

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