Abstract
This study tried to mathematically unveil the difficulties associated with an anti-HIV therapy based on the lethal mutagenesis method; two difficulties were identified. The first difficulty of this method was that the efficacy of a mutagen must be over a certain threshold to treat HIV-1 infection, which could explain the apparent failure of the KP-1461 trial. Furthermore, we investigated the influence of the latency of HIV-1 on the treatment period and clarified that the latency increases the treatment period in a manner almost independent of the efficacy of a mutagen. This is the second difficulty associated with the lethal mutagenesis method.
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Harada, K. A mathematical study for the development of anti-HIV-1 therapies based on the lethal mutagenesis method. Artif Life Robotics 25, 273–277 (2020). https://doi.org/10.1007/s10015-019-00578-2
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DOI: https://doi.org/10.1007/s10015-019-00578-2