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Computational Control of an HIV Model

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Abstract

We consider a computational approach to solving an optimal control formulation of optimal drug scheduling in HIV infected individuals. The optimal control problem is transformed using the control parameterisation enhancing technique (CPET), which enables efficient computation of an optimal control using a relatively coarse discretisation. A number of numerical difficulties with the model are discussed, and for illustration, numerical examples are solved.

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Authors and Affiliations

  1. School of Computational and Applied Mathematics, University of the Witwatersrand, Private Bag X1, PO WITS, 2050, South Africa

    C. Myburgh & K. H. Wong

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  1. C. Myburgh
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  2. K. H. Wong
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Correspondence to C. Myburgh.

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Myburgh, C., Wong, K.H. Computational Control of an HIV Model. Ann Oper Res 133, 277–283 (2005). https://doi.org/10.1007/s10479-004-5038-6

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  • DOI: https://doi.org/10.1007/s10479-004-5038-6

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