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Diagnosis of Diabetic Retinopathy: Automatic Extraction of Optic Disc and Exudates from Retinal Images using Marker-controlled Watershed Transformation

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Abstract

Due to increasing number of diabetic retinopathy cases, ophthalmologists are experiencing serious problem to automatically extract the features from the retinal images. Optic disc (OD), exudates, and cotton wool spots are the main features of fundus images which are used for diagnosing eye diseases, such as diabetic retinopathy and glaucoma. In this paper, a new algorithm for the extraction of these bright objects from fundus images based on marker-controlled watershed segmentation is presented. The proposed algorithm makes use of average filtering and contrast adjustment as preprocessing steps. The concept of the markers is used to modify the gradient before the watershed transformation is applied. The performance of the proposed algorithm is evaluated using the test images of STARE and DRIVE databases. It is shown that the proposed method can yield an average sensitivity value of about 95%, which is comparable to those obtained by the known methods.

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References

  1. Reza, A. W., Eswaran, C., and Hati, S., Diabetic retinopathy: A quadtree based blood vessel detection algorithm using RGB components in fundus images. J. Med. Syst. 32(2):147–155, 2008.

    Article  Google Scholar 

  2. Teng, T., Lefley, M., and Claremont, D., Progress towards automated diabetic ocular screening: A review of image analysis and intelligent systems for diabetic retinopathy. Med. Biol. Eng. Comput. 40:2–13, 2002.

    Article  Google Scholar 

  3. Yen, G. G., and Leong, W.-F., A sorting system for hierarchical grading of diabetic fundus images: A preliminary study. IEEE Trans Inf Technol Biomed 12(1):118–130, 2008.

    Article  Google Scholar 

  4. Usher, D., Dumskyj, M., Himaga, M., Williamson, T. H., Nussey, S., and Boyce, J., Automated detection of diabetic retinopathy in digital retinal images: A tool for diabetic retinopathy screening. Diabet. Med. 21:84–90, 2003.

    Article  Google Scholar 

  5. Reza, A. W., Eswaran, C., and Hati, S., Automatic tracing of optic disc and exudates from color fundus images using fixed and variable thresholds. J. Med. Syst. 33(1):73–80, 2009.

    Article  Google Scholar 

  6. Eswaran, C., Reza, A. W., and Hati, S., Extraction of the contours of optic disc and exudates based on marker-controlled watershed segmentation. Proceedings of the International Conference on Computer Science and Information Technology, Singapore, pp. 719–723, 2008.

  7. Walter, T., Klein, J.-C., Massin, P., and Erginay, A., A contribution of image processing to the diagnosis of diabetic retinopathy—Detection of exudates in color fundus images of the human retina. IEEE Trans. Med. Imag. 21(10):1236–1243, 2002.

    Article  Google Scholar 

  8. Ward, N. P., Tomlinson, S., and Taylor, C. J., Image analysis of fundus photographs—The detection and measurement of exudates associated with diabetic retinopathy. Opthalmol. 96:80–86, 1989.

    Google Scholar 

  9. Akita, K., and Kuga, H., A computer method of understanding ocular fundus images. Pattern Recogn. 15(6):431–443, 1982.

    Article  Google Scholar 

  10. Sinthanayothin, C., Boyce, J. F., Cook, H. L., and Williamson, T. H., Automated localization of the optic disc, fovea and retinal blood vessels from digital color fundus images. Br. J. Opthalmol. 83:231–238, 1999.

    Article  Google Scholar 

  11. Tamura, S., and Okamoto, Y., Zero-crossing interval correction in tracing eye-fundus blood vessels. Pattern Recogn. 21(3):227–233, 1988.

    Article  Google Scholar 

  12. Pinz, A., Prantl, M., and Datlinger, P., Mapping the human retina. IEEE Trans. Med. Imag. 1:210–215, 1998.

    Google Scholar 

  13. Mendels, F., Heneghan, C., and Thiran, J.-P., Identification of the optic disc boundary in retinal images using active contours. Proceedings of Irish Machine Vision image Processing (IMVIP), Maynooth, Ireland, pp. 103–115, 1999.

  14. Walter, T., and Klein, J. C., Segmentation of color fundus images of the human retina: Detection of the optic disc and the vascular tree using morphological techniques. Proceedings of the second International Symposium: Medical Data Analysis, Madrid, Spain, pp. 282–287, 2001.

  15. Li, H., and Chutatape, O., Automatic detection and boundary estimation of the optic disk in retinal images using a model-based approach. J. Electron. Imag. 12(1):97–105, 2003.

    Article  Google Scholar 

  16. Li, H., and Chutatape, O., Automated feature extraction in color retinal images by a model based approach. IEEE Trans. Biomed. Eng. 51(2):246–254, 2004.

    Article  Google Scholar 

  17. Niemeijer, M., Abramoff, M. D., and van Ginneken, B., Segmentation of the optic disc, macula and vascular arch in fundus photographs. IEEE Trans. Med. Imag. 26(1):116–127, 2007.

    Article  Google Scholar 

  18. Vallabha, D., Dorairaj, R., Namuduri, K., and Thompson, H., Automated detection and classification of vascular abnormalities in diabetic retinopathy. Proceedings of Thirty-Eighth Asilomar Conference on Signals, Systems and Computers, vol. 2, pp. 1625–1629, 2004.

  19. Phillips, R., Forrester, J., and Sharp, P., Automated detection and quanification of retinal exudates. Graefe’s Arch. Clin. Exp. Opthalmol. 231:90–94, 1993.

    Article  Google Scholar 

  20. Osareh, A., Mirmehdi, M., Thomas, B., and Markham, R., Automatic recognition of exudative maculopathy using fuzzy c-means clustering and neural networks. Proceedings of Medical Image Understanding Analysis, UK, pp. 49–52, 2001.

  21. Reza, A. W., and Eswaran, C., A decision support system for automatic screening of non-proliferative diabetic retinopathy. J. Med. Syst. Springer, 2009. doi:10.1007/s10916-009-9337-y.

    Google Scholar 

  22. Gonzalez, R. C., Woods, R. E., and Eddins, S. L., Digital image processing using MATLAB. Prentice Hall, Upper Saddle River, 2004.

    Google Scholar 

  23. Soille, P., Morphological image analysis: principles and applications, 2nd edition. Springer-Verlag, New York, 2002.

    Google Scholar 

  24. Image Processing Toolbox, User’s Guide, Version 4, The Math Works, Inc., Natick, MA, 2003.

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Acknowledgment

This research work is supported by E-Science Project (No: 01-02-01-SF0025) sponsored by Ministry of Science, Technology and Innovation (MOSTI), Malaysia.

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Correspondence to Ahmed Wasif Reza.

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Reza, A.W., Eswaran, C. & Dimyati, K. Diagnosis of Diabetic Retinopathy: Automatic Extraction of Optic Disc and Exudates from Retinal Images using Marker-controlled Watershed Transformation. J Med Syst 35, 1491–1501 (2011). https://doi.org/10.1007/s10916-009-9426-y

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  • DOI: https://doi.org/10.1007/s10916-009-9426-y

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