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Alterations in Regional Homogeneity Assessed by fMRI in Patients with Migraine Without Aura

  • Patient Facing Systems
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Abstract

The aim of this study was to investigate the alterations in regional homogeneity assessed by fMRI in patients with migraine without aura (MWoA). Fifty-six eligible MWoA patients and 32 matched healthy volunteers were enrolled in this study. MWoA patients were divided into three groups according to the headache days per month within 3 months: infrequent episodic migraine (IEM) group, frequent episodic migraine (FEM) group, and chronic migraine (CM) group. Data collection and rest-state fMRI examination were performed in all cases. The ReHo method was used to analyze the blood oxygen level dependent (BLOD) signals of the adjacent voxels in the brain regions of each patient, and the consistency of their fluctuations in the sequences of same time. Compared with normal controls, ReHo values of bilateral thalami, right insula and right middle temporal gyrus increased and both precentral gyri decreased in the IEM group; ReHo values of bilateral thalami and the right middle temporal gyrus increased; ReHo values of both anterior cingulate cortex, precentral gyri and putamen decreased in the FEM group. Compared with control group, ReHo values of left olfactory cortex, right hippocampus, parahippocampal gyrus, suboccipital gyrus and precuneus increased, both precentral gyri, precuneus, putamen and anterior cingulate cortex decreased in the CM group. Compared with IEM group, ReHo values of both putamen, left middle frontal gyrus, right superior frontal gyrus increased, and the left precuneus decreased in the FEM group. Compared with FEM group, ReHo values of left olfactory and left precuneus increased, and the right superior frontal gyrus, insula, middle temporal gyrus, thalami, both superior temporal gyri decreased in the CM group. In the IEM group, the changes of function focus on the regions associated with coding, conduction and regulation of pain signals. In the FEM group, functional alterations mainly concentrated on the regions associated with pain regulation and emotion cognition. In the CM group, the changes focus on the regions related to spatial attention and cognition, affective disorders and pain feedback, which may be associated with migraine production, development and chronification.

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China

    Can Chen*, Manyun Yan*, Yang Yu, Jun Ke, Chunyang Xu, Xiaoning Guo, Haifeng Lu, Ximing Wang, Jianqiang Ni & Hongru Zhao

  2. Department of Neurology, Ninth People’s Hospital of Suzhou, Suzhou, 215200, China

    Lan Hu & Jingwen Wang

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  1. Can Chen*
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  2. Manyun Yan*
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  3. Yang Yu
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Correspondence to Hongru Zhao.

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This article is part of the Topical Collection on Patient Facing Systems

Can Chen and Manyun Yan are co-first authors

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Chen*, C., Yan*, M., Yu, Y. et al. Alterations in Regional Homogeneity Assessed by fMRI in Patients with Migraine Without Aura. J Med Syst 43, 298 (2019). https://doi.org/10.1007/s10916-019-1425-z

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