Skip to main content

Advertisement

Log in

Glaucoma diagnosis in fundus eye images using diversity indexes

  • Published:
Multimedia Tools and Applications Aims and scope Submit manuscript

Abstract

Glaucoma is the second major cause of vision loss worldwide. It is usually caused by the increase in the intraocular pressure, which damages the optic nerve resulting in gradual vision loss. Glaucoma is an asymptomatic disease in the initial stages. Early detection and treatment may prevent the vision loss. The head of the optic nerve (optic disc) is examined by using fundus eye images. Computer systems have been used to provide support in glaucoma diagnosis. This work proposes a method for glaucoma diagnosis using fundus eye images. Diversity indexes, which are typically used in ecological studies, are used in this work as texture descriptors in the optic disc region. Then, a feature selection procedure is performed using genetic algorithm and support vector machines (SVM) are used to classify fundus eye images in glaucomatous or normal. The proposed method obtained promising results for glaucoma diagnosis, reaching an accuracy of 93.41%, sensitivity of 92.83% and specificity of 93.69%.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Abramoff MD, Garvin MK, Sonka M (2010) Retinal imaging and image analysis. IEEE Rev Biomed Eng 3:169–208. https://doi.org/10.1109/RBME.2010.2084567

    Article  Google Scholar 

  2. Acharya UR, Ng EYK, Eugene LWJ, Noronha KP, Min LC, Nayak KP, Bhandary SV (2014) Decision support system for the glaucoma using Gabor transformation. Biomed Signal Process Control 15:18–26. https://doi.org/10.1016/j.bspc.2014.09.004

    Article  Google Scholar 

  3. Al-Bander B, Al-Nuaimy W, Al-Taee MA, Zheng Y (2017) Automated glaucoma diagnosis using deep learning approach. In: 2017 14th international multi-conference on systems, signals devices (SSD), pp 207–210. https://doi.org/10.1109/SSD.2017.8166974

  4. Almazroa A, Burman R, Raahemifar K, Lakshminarayanan V (2015) Optic disc and optic cup segmentation methodologies for glaucoma image detection: a survey. J Ophthalmol 2015

  5. Banić N, LonCcarić S (2013) Light random sprays retinex: exploiting the noisy illumination estimation. IEEE Signal Process Lett 20 (12):1240–1243. https://doi.org/10.1109/LSP.2013.2285960

    Article  Google Scholar 

  6. Bland M (2015) An introduction to medical statistics. Oxford University Press, London

    MATH  Google Scholar 

  7. Bock R, Meier J, Nyúl LG, Hornegger J, Michelson G (2010) Glaucoma risk index:automated glaucoma detection from color fundus images. Med Image Anal 14(3):471–481. https://doi.org/10.1016/j.media.2009.12.006. http://www.sciencedirect.com/science/article/pii/S1361841509001509

    Article  Google Scholar 

  8. Chang CC, Lin CJ (2011) Libsvm: a library for support vector machines. ACM Trans Intell Syst Technol 2(3):27:1–27:27. https://doi.org/10.1145/1961189.1961199. http://doi.acm.org/10.1145/1961189.1961199

    Article  Google Scholar 

  9. de Sousa JA, de Paiva AC, Sousa de Almeida JD, Silva AC, Junior GB, Gattass M (2017) Texture based on geostatistic for glaucoma diagnosis from fundus eye image. Multimedia Tools and Applications 76(18):19,173–19,190. https://doi.org/10.1007/s11042-017-4608-y

    Article  Google Scholar 

  10. Duda H (1973) Pattern classification and scene analysis. Wiley, New York

    MATH  Google Scholar 

  11. Faust O, Acharya R, Ng EYK, Ng KH, Suri JS (2012) Algorithms for the automated detection of diabetic retinopathy using digital fundus images: a review. J Med Syst 36(1):145–157

    Article  Google Scholar 

  12. Gajbhiye GO, Kamthane AN (2015) Automatic classification of glaucomatous images using wavelet and moment feature. In: 2015 annual IEEE India conference (INDICON), pp 1–5. https://doi.org/10.1109/INDICON.2015.7443150

  13. Goldberg DE (1989) Genetic algorithms in search, optimization, and machine learning, 1989. Addison-Wesley, Reading

    MATH  Google Scholar 

  14. Gonzalez RC, Woods R (2010) Processamento digital de imagens. Tradução de Cristina Yamagami e Leonardo Piamonte

  15. Haleem MS, Han L, van Hemert J, Li B (2013) Automatic extraction of retinal features from colour retinal images for glaucoma diagnosis: a review. Comput Med Imaging Graph 37(7–8):581 – 596. https://doi.org/10.1016/j.compmedimag.2013.09.005. http://www.sciencedirect.com/science/article/pii/S0895611113001468

    Article  Google Scholar 

  16. Hani AFM, Soomro TA, Faye I, Kamel N, Yahya N (2014) Denoising methods for retinal fundus images. In: 2014 5th international conference on intelligent and advanced systems (ICIAS), pp 1–6. https://doi.org/10.1109/ICIAS.2014.6869534

  17. Kanan C, Cottrell GW (2012) Color-to-grayscale: does the method matter in image recognition? PLOS ONE 7(1):1–7. https://doi.org/10.1371/journal.pone.0029740

    Article  Google Scholar 

  18. Koh JE, Mookiah MRK, Kadri NA (2013) Application of multiresolution analysis for the detection of glaucoma. J Med Imaging Health Inf 3(3):401–408

    Article  Google Scholar 

  19. Kumar HV, Jayaram A, Karegowda A, Bharathi P (2016) A comparative study on filters with specila reference to retinal images. Proc Int J Comput Appl 138 (5):81–6

    Google Scholar 

  20. Land EH, McCann JJ (1971) Lightness and retinex theory. J Opt Soc Am 61(1):1–11. https://doi.org/10.1364/JOSA.61.000001. http://www.osapublishing.org/abstract.cfm?URI=josa-61-1-1

    Article  Google Scholar 

  21. Lin SC, Singh K, Jampel HD, Hodapp EA, Smith SD, Francis BA, Dueker DK, Fechtner RD, Samples JS, Schuman JS et al (2007) Optic nerve head and retinal nerve fiber layer analysis: a report by the american academy of ophthalmology. Ophthalmology 114(10):1937–1949

    Article  Google Scholar 

  22. Maheshwari S, Pachori RB, Acharya UR (2017) Automated diagnosis of glaucoma using empirical wavelet transform and correntropy features extracted from fundus images. IEEE Journal of Biomedical and Health Informatics 21(3):803–813. https://doi.org/10.1109/JBHI.2016.2544961

    Article  Google Scholar 

  23. Maheshwari S, Pachori RB, Kanhangad V, Bhandary SV, Acharya UR (2017) Iterative variational mode decomposition based automated detection of glaucoma using fundus images. Comput Biol Chem 88:142–149. https://doi.org/10.1016/j.compbiomed.2017.06.017. http://www.sciencedirect.com/science/article/pii/S0010482517301816

    Google Scholar 

  24. Marrugan A (2004) Measuring biological diversity. Blackwell Scienc Ltd a Blackwell Publishing Company, Carlton

    Google Scholar 

  25. Mary MCVS, Rajsingh EB, Naik GR (2016) Retinal fundus image analysis for diagnosis of glaucoma: A comprehensive survey. IEEE Access 4:4327–4354. https://doi.org/10.1109/ACCESS.2016.2596761

    Article  Google Scholar 

  26. McIntosh RP (1967) An index of diversity and the relation of certain concepts to diversity. Ecology 48(3):392–404. http://www.jstor.org/stable/1932674

    Article  Google Scholar 

  27. Mookiah MRK, Acharya UR, Lim CM, Petznick A, Suri JS (2012) Data mining technique for automated diagnosis of glaucoma using higher order spectra and wavelet energy features. Knowl-Based Syst 33:73–82. https://doi.org/10.1016/j.knosys.2012.02.010. http://www.sciencedirect.com/science/article/pii/S0950705112000500

    Article  Google Scholar 

  28. Noronha KP, Acharya UR, Nayak KP, Martis RJ, Bhandary SV (2014) Automated classification of glaucoma stages using higher order cumulant features. Biomedical Signal Processing and Control 10:174–183. https://doi.org/10.1016/j.bspc.2013.11.006. http://www.sciencedirect.com/science/article/pii/S1746809413001699

    Article  Google Scholar 

  29. Oh JE, Yang HK, Kim KG, Hwang JM (2015) Automatic computer-aided diagnosis of retinal nerve fiber layer defects using fundus photographs in optic neuropathy. Investig Ophthalmol Vis Sci 56(5):2872. https://doi.org/10.1167/iovs.14-15096. https://iovs.arvojournals.org/article.aspx?articleid=2290717

    Article  Google Scholar 

  30. Raja C, Gangatharan N (2015) A hybrid swarm algorithm for optimizing glaucoma diagnosis. Comput Biol Med 63:196–207. https://doi.org/10.1016/j.compbiomed.2015.05.018. http://www.sciencedirect.com/science/article/pii/S001048251500195X

    Article  Google Scholar 

  31. Ramasubramanian B, Selvaperumal S (2016) A comprehensive review on various preprocessing methods in detecting diabetic retinopathy. In: 2016 international conference on communication and signal processing (ICCSP), pp 0642–0646. https://doi.org/10.1109/ICCSP.2016.7754220

  32. Shannon CE, Weaver W (1949) The mathematical theory of communication. University of Illinois Press, Urbana, p 29

    MATH  Google Scholar 

  33. Siedlecki W, Sklansky J (1989) A note on genetic algorithms for large-scale feature selection. Pattern Recogn Lett 10(5):335–347. https://doi.org/10.1016/0167-8655(89)90037-8. http://www.sciencedirect.com/science/article/pii/0167865589900378

    Article  MATH  Google Scholar 

  34. Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology 121(11):2081–2090. https://doi.org/10.1016/j.ophtha.2014.05.013. http://www.sciencedirect.com/science/article/pii/S0161642014004333

    Article  Google Scholar 

  35. Trucco E, Ruggeri A, Karnowski T, Giancardo L, Chaum E, Hubschman JP, Al-Diri B, Cheung CY, Wong D, Abramoff M et al (2013) Validating retinal fundus image analysis algorithms: Issues and a proposalvalidating retinal fundus image analysis algorithms. Investig Ophthalmol Vis Sci 54(5):3546–3559

    Article  Google Scholar 

  36. Vapnik V (1998) Statistical learning theory. Wiley, New York

    MATH  Google Scholar 

  37. WGA (2017) What is glaucoma? http://www.worldglaucoma.org/what-is-glaucoma/. Accessed 17 Mar 2017

  38. Zhang Z, Srivastava R, Liu H, Chen X, Duan L, Kee Wong DW, Kwoh CK, Wong TY, Liu J (2014) A survey on computer aided diagnosis for ocular diseases. BMC Medical Informatics and Decision Making 14(1):80. https://doi.org/10.1186/1472-6947-14-80

    Article  Google Scholar 

  39. Zhuang L, Dai H (2006) Parameter optimization of kernel-based one-class classifier on imbalance learning. Journal of Computers 1(7):32–40

    Article  Google Scholar 

Download references

Acknowledgments

The authors acknowledge the Coordination for the Improvement of Higher Education Personnel (CAPES), the National Council for Scientific and Technological Development (CNPq), the Foundation for the Protection of Research and Scientific, the Technological Development of the State of Maranhão (FAPEMA) for financial support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to José Denes Lima Araújo.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Araújo, J.D.L., Souza, J.C., Neto, O.P.S. et al. Glaucoma diagnosis in fundus eye images using diversity indexes. Multimed Tools Appl 78, 12987–13004 (2019). https://doi.org/10.1007/s11042-018-6429-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11042-018-6429-z

Keywords

Navigation