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Flows in micro fluidic networks: From theory to experiment

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Abstract

When complex flow structures are designed, such as in DNA computing, it is essential to be able to predict the flow pattern of the solutions in the fluidic network. A model based on the resistance of the channels and flow velocities of the inlets can eliminated re-iterative design steps. We have constructed a symbolic model using Mathematica ® to determine the desired flow pattern based on the equations of Ohm and Kirchoff. The values from this simulation were used in a flow simulation program and then tested in a microflow network. Results show that the simulation and calculation match very well, while the experiments in the fluidic network show a flow pattern as predicted by the model.

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References

  • Bardell LR and Forster FK (1998) Impedances for design of microfluidic systems. In: Proc. of the Micro-TAS ’98 Workshop, Banff, Canada, 13–16 October 1998, http://lettuce.me.washington.edu /micropump/puplication/1998utas98wE.htm

  • Bardell LR, Sharma NR, Forster FK, Afromowitz MA, Penney RJ (1997) Designing high-performance micro-pumps based on non-moving parts. Microelectromechanical Systems (MEMS) ASME 1997, DSC-Vol 62/HTD-Vol. 354, pp. 47–53

  • Bochman A (1996) Diploma Thesis. Univ. Jena

  • RS Braich N Chelyapov C Johnson PWK Rothemund L Adleman (2002) ArticleTitleSolution of a 20-variable 3-SAT problem on a DNA computer Science 296 499–502

    Google Scholar 

  • A Gehani J Reif (1999) ArticleTitleMicro flow bio-molecular computation Biosystems 52 197–216

    Google Scholar 

  • J Happel H Brenner (1983) Low Reynolds Number Hydrodynamics. Martinus Nijhof Publishers the Hague

    Google Scholar 

  • JS McCaskill (2001) ArticleTitleOptically programming DNA computing in microflow reactors Biosystems 59 125–138

    Google Scholar 

  • Pun P, Rozenberg G and Salomaa A (1998) DNA Computing: New Computing Paradigms. Springer Verlag, Heidelberg, Germany. ISBN 3-540-64196-3

  • Schmidt K, Foerster P, Bochmann A and McCaskill JS (1997) A microflow reactor for two dimensional investigations of in vitro amplification systems. In: 1st International Conference on Microreaction Technology, Book of abstracts, Dechema e.V., Frankfurt am Main

  • van Noort D (2004) A programmable molecular computer in microreactors. In: Preliminary Proceedings, Tenth International Meeting on DNA Based Computers, June 7–10, Italy

  • van Noort D and Landweber LFL (2004) Towards a re-programmable DNA computer. J. Nat. Comput. (accepted for publication)

  • D Noort Particlevan F-U Gast JS McCaskill (2002a) ArticleTitleDNA computing in microreactors LNCS 2340 33–45

    Google Scholar 

  • D Noort Particlevan P Wagler JS McCaskill (2002b) ArticleTitleThe role of microreactors in molecular computing Smart Mater. Struct. 11 756–760

    Google Scholar 

  • P.Wagler,Gohlke M.,van Noort D.,McCaskill JS.,2001Three-dimensional microfluidic systems for computation with DNA molecules,In: 12th Micromechanics Europe Workshop MME 2001, Proceedings Cork, Ireland

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Author notes

  1. Danny Van Noort

    Present address: School of Computer Science and Engineering Seoul National University, San 56-1, Sinlim-dong, Seoul, 151-742, Korea

Authors and Affiliations

  1. Department of Ecology and Evolutionary Biology, Guyot Hall, Princeton University, Princeton, 08544, NJ, USA

    Danny Van Noort

  2. Biomolecular Information Processing, Ruhr-Universität Bochum c/o Fraunhofer Institutszentrum Schloss Birlinghoven, D-53754, Sankt Augustin, Germany

    John S. Mccaskill

Authors
  1. Danny Van Noort
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  2. John S. Mccaskill
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Correspondence to Danny Van Noort.

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Noort, D.V., Mccaskill, J.S. Flows in micro fluidic networks: From theory to experiment. Nat Comput 3, 395–410 (2004). https://doi.org/10.1007/s11047-004-2667-2

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  • DOI: https://doi.org/10.1007/s11047-004-2667-2

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