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Permutation entropy improves fetal behavioural state classification based on heart rate analysis from biomagnetic recordings in near term fetuses

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Abstract

The relevance of the complexity of fetal heart rate fluctuations with regard to the classification of fetal behavioural states has not been satisfyingly clarified so far. Because of the short behavioural states, the permutation entropy provides an advantageous complexity estimation leading to the Kullback–Leibler entropy (KLE). We test the hypothesis that parameters derived from KLE can improve the classification of fetal behaviour states based on classical heart rate fluctuation parameters (SDNN, RMSSD, ln(LF), ln(HF)). From measured heartbeat sequences (35 healthy fetuses at a gestational age between 35 and 40 completed weeks) representative intervals of 256 heartbeats were visually preclassified into fetal behavioural states. Employing discriminant analysis to separate the states 1F, 2F and 4F, the best classification result by classical parameters was 80.0% (SDNN). After additionally considering KLE parameters it was improved significantly (p<0.0005) to 94.3% (ln(LF), KLE_Mean). It could be confirmed that KLE can improve the state classification. This might reflect the consideration of different physiological aspects by classical and complexity measures.

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Acknowledgements

This work was supported by grants from the Deutsche Forschungsgemeinschaft (HO 1634/9-1, KA 1726/2-1). The authors like to thank Barbara Grimm and Alina Schneider for their assistance in obtain the raw data and the team of the Biomagnetic Center, Department of Neurology, Friedrich Schiller University Jena for their technical support.

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Authors and Affiliations

  1. Institute for Pathophysiology and Pathobiochemistry, and Biomagnetic Center, Department of Neurology, Friedrich Schiller University, Jena, Germany

    B. Frank & D. Hoyer

  2. Institute of Physics, Ernst Moritz Arndt University, Greifswald, Germany

    B. Pompe

  3. Department of Obstetrics and Gynaecology, Friedrich Schiller University, Jena, Germany

    U. Schneider

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  1. B. Frank
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  2. B. Pompe
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  3. U. Schneider
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  4. D. Hoyer
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Correspondence to B. Frank.

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Frank, B., Pompe, B., Schneider, U. et al. Permutation entropy improves fetal behavioural state classification based on heart rate analysis from biomagnetic recordings in near term fetuses. Med Bio Eng Comput 44, 179–187 (2006). https://doi.org/10.1007/s11517-005-0015-z

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  • DOI: https://doi.org/10.1007/s11517-005-0015-z

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