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Spontaneous contractions of isolated rat portal vein under temperature perturbations

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Abstract

We studied nonlinear dynamics underlying spontaneous rhythmical contractions of isolated rat portal vein. The signals were acquired at four different temperatures important in isolated blood vessels preparations: 4, 22, 37 and 40°C. To characterize the system’s nonlinearity, we calculated the largest Lyapunov exponent, sample entropy and scaling exponents. Evidence for nonlinearity was provided by analysis of surrogate data generated from the phase-randomized Fourier transform of the original sequences. Positive values of the largest Lyapunov exponent were obtained for the time series recorded under applied conditions, indicating that the system preserves its chaotic deterministic nature even far from the physiological temperature range. Scaling exponents revealed three distinctive regions with different correlation properties. The calculated measures that characterize the time series obtained at 4°C were significantly different from those derived from data obtained at higher temperatures. System’s dynamics becomes more complex or less predictable as temperature approaches physiological value. The computation of the largest Lyapunov exponent, sample entropy and correlation measures gave an insight into the complex dynamics of the isolated blood vessels rhythmicity. We identified different modes of rhythmical contractions of isolated rat portal vein which could improve understanding of possible control mechanisms in vivo.

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Acknowledgment

The authors would like to thank Ms Milena Zabunović and Ms Dragana Protić for their devoted and thorough work in execution of the experiments. The work is supported by the Karl and Lore Klein-Foundation and Serbian Ministry of Science and Technological Development (grant 141042 and TP20027).

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Authors and Affiliations

  1. Institute of Biophysics, Faculty of Medicine, University of Belgrade, Višegradska 26/2, 11 000, Belgrade, Serbia

    Vesna Vuksanović, Vera Gal & Mirjana M. Platiša

  2. Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Dr Subotića 1, Belgrade, Serbia

    Ljiljana Gojković-Bukarica

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  1. Vesna Vuksanović
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  2. Vera Gal
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  3. Mirjana M. Platiša
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  4. Ljiljana Gojković-Bukarica
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Correspondence to Vesna Vuksanović.

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Vuksanović, V., Gal, V., Platiša, M.M. et al. Spontaneous contractions of isolated rat portal vein under temperature perturbations. Med Biol Eng Comput 48, 887–894 (2010). https://doi.org/10.1007/s11517-010-0643-9

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  • DOI: https://doi.org/10.1007/s11517-010-0643-9

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