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Young and advanced tumor—some 2D electrodynamic distinctions: melanoma and satellite during a vascular occlusion test: feasibility study

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Abstract

Conventional methods of electrobioimpedance imaging are not suited for adequate visualization of the skin electrical impedance landscape (SEL) because they do not provide high spatial resolution at large enough area of view. The skin electrodynamics introscopy (SEI) enabled dynamic spectral imaging of the SEL at 32 × 64 mm2 area with 1 mm spatial resolution. The focus of the study was to investigate the SEL distinguishing features between early and advanced-stage cancer at the model object of melanoma and its satellite. The analysis of the test-induced SEL metamorphoses was carried out at the periods of blood-stop and blood-restoration. It was found that the young tumor could be reliably visualized and distinguished by its antiphase hypoxia-induced response as compared to that of the advanced one. In response to the blood-restoration, an appearance of newly formed SEL clusters pointed out apparently at vascular abnormalities associated with the tumor. Similar SEL clusterization can be supposedly expected in response to any other test factors which affect cell permeability or/and blood viscosity. The proposed approach might be useful for more thorough mapping and staging malignancies.

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Acknowledgements

We kindly acknowledge Prof. Uwe Pliquett and Prof. Vitaliy Maksymenko for the fruitful discussions and remarks.

Glossary

θ k , θ M - phase angles at 2 kHz and 1 MHz (in degrees), (i.e., Z = |Z|ejθ)

σ - standard deviation

|Z k |, |Z M | - electrical impedance modules at 2 kHz and 1 MHz (in kOhms), respectfully

2D - two dimensional

MIX = |Z k |/|Z M - |magnitude index

MV - mean value

PIX = (θ k –θ M ) - phase index (in degrees)

p - significance level

r - correlation coefficient

SEL - the skin electrical impedance landscape

SEI - the skin electrodynamics introscopy

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Authors and Affiliations

  1. Amosov National Institute of Cardiovascular Surgery, M. Amosova St., 6, Kiev, 03038, Ukraine

    Y. Babich

  2. Taras Shevchenko National University of Kiev, Astronomical Observatory, Observatorna St., 3, Kiev, 04053, Ukraine

    M. Nuzhdina

  3. Institute of Nuclear Medicine and Diagnostic Radiology, NAMS of Ukraine, Mayborody St. 32, Kiev, 04050, Ukraine

    S. Syniuta

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  1. Y. Babich
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Correspondence to Y. Babich.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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The authors declare no conflict of interest.

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Babich, Y., Nuzhdina, M. & Syniuta, S. Young and advanced tumor—some 2D electrodynamic distinctions: melanoma and satellite during a vascular occlusion test: feasibility study. Med Biol Eng Comput 56, 211–220 (2018). https://doi.org/10.1007/s11517-017-1668-0

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