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Hemodynamic effects of intravenous bolus injection of iopromide 370 twice in abdominal contrast-enhanced CT and coronary CTA dual-site sequential examinations

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Abstract

Little information is available about how intravenous bolus injection of iopromide 370 twice in a short time will affect hemodynamics and whether the changes reach clinically relevant levels. In the present study, 31 healthy adult volunteers received abdominal contrast-enhanced CT and coronary CTA sequential examinations. The same dose and rate of normal saline was injected 30 min in advance as self-control. Hemodynamic data were noninvasively collected at selected time points from 1 min prior to injection to 30 min post-injection. The results showed that after iopromide 370 injection, except for stroke volume, all other indicators changed immediately during the first injection, changed most significantly during the second injection (P < 0.05), and returned to baseline within 10 min. Heart rate and cardiac output exhibited the most pronounced changes, with an increasing rate of 33.5% and 33.8%, respectively. For indicators with a change range of > 15% during the second injection, except for mean arterial pressure and total peripheral resistance, the proportions of subjects for the other indicators between the two groups were statistically different (P < 0.05). In conclusion, intravenous bolus injection of iopromide 370 twice in dual-site sequential examinations induced dose-cumulative and time-dependent hemodynamic effects, which all fluctuated within the normal ranges.

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Abbreviations

NICM:

Non-ionic iodinated contrast media

CECT:

Contrast-enhanced CT

ADR:

Adverse drug reactions

SBP:

Systolic blood pressure

DBP:

Diastolic blood pressure

MAP:

Mean arterial pressure

HR:

Heart rate

CO:

Cardiac output

SV:

Stroke volume

TPR:

Total peripheral resistance

NS:

Normal saline

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Funding

This work was supported by the Fund of Chongqing 2019 Science and Technology Joint Medical Research Project (2019ZDXM049).

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Author notes

  1. Lingru Wang and Haiyan Qiu contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Daping Hospital, Army Medical University, No. 10 Changjiang Road, Yuzhong District, Chongqing, 400042, China

    Lingru Wang, Haiyan Qiu, Lan Chen, Heng Liu, Junling Liu, Ying Yang, Yueting Sun, Yang Deng, Heng Liu & Xue Li

  2. Department of Radiology, PLA Rocket Force Characteristic Medical Center, No. 16 Xinjiekou Outer Street, Beijing, 100088, China

    Heng Liu

  3. Chongqing Clinical Research Center for Imaging and Nuclear Medicine, Chongqing, 400042, China

    Xue Li

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  1. Lingru Wang
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Contributions

Guarantors of integrity of entire study, H.L., X.L.; study concepts/study design, H.L., X.L.; data acquisition or data analysis/interpretation, all authors; manuscript drafting for important intellectual content, L.R.W., H.Y.Q; approval of final version of submitted manuscript, all authors; agrees to ensure any questions related to the work are appropriately resolved, all authors; clinical studies, all authors; statistical analysis, L.R.W., H.L.; and manuscript editing, H.L., X.L.

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Correspondence to Heng Liu or Xue Li.

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Wang, L., Qiu, H., Chen, L. et al. Hemodynamic effects of intravenous bolus injection of iopromide 370 twice in abdominal contrast-enhanced CT and coronary CTA dual-site sequential examinations. Med Biol Eng Comput 61, 179–194 (2023). https://doi.org/10.1007/s11517-022-02705-x

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